The pathology of Psoroptes ovis infestation in cattle with a special emphasis on breed difference

Losson, Bertrand; Lonneux, J. F.; Lekimme, Mireille

doi:10.1016/s0304-4017(99)00059-x

Cited by 37 publications

(41 citation statements)

References 27 publications

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“…A different skin reaction pattern against P. ovis in BB cattle compared to Holstein cattle could also explain the apparent reduced efficacy of ivermectin in this breed. Losson et al (1999) showed that an intradermal injection of Psoroptes cuniculi antigen in P. ovis-infected BB and Holstein cattle resulted in a delayed hypersensitivity reaction only in BB cattle. This may explain the more severe and prolonged skin reactions observed in this breed during a Psoroptes infestation.…”

Section: Discussionmentioning

confidence: 99%

“…Belgian Blue (BB) cattle appear to be very sensitive to Psoroptes ovis (Losson et al, 1999) and, unlike the case in cattle of the Holstein (and other breeds), single treatments with ivermectin do not always result in complete elimination of the parasite (unpublished results). The reason for this reduced efficacy is unknown, but a possible explanation is that differences in the systemic availability of ivermectin could lead to a lower exposure of parasites to the drug in BB calves compared to Holstein calves.…”

Section: Introductionmentioning

confidence: 99%

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Breed differences in the pharmacokinetics of ivermectin administered subcutaneously to Holstein and Belgian Blue calves

Vercruysse

Deprez

Everaert

et al. 2008

Veterinary Parasitology

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Belgian Blue (BB) cattle are very sensitive to mange caused by Psoroptes ovis and, in contrast to the case in Holstein cattle, single treatments with ivermectin do not result in complete elimination of the parasite. The objective of the present study was to determine the concentration of ivermectin in plasma, skin and hair following subcutaneous administration to Holstein and BB calves and to assess the influence of breed on drug pharmacokinetics and availability. Two groups of six healthy female Holstein and BB calves were treated with ivermectin (SC formulation) at a dose of 0.2 mg/kg. Blood, skin and hair were collected before treatment and up to 21 days after treatment. Ivermectin was analyzed in plasma and tissue by high-performance liquid chromatography (HPLC). The peak concentrations (C max ), time-peak concentrations (T max ), the area under the plasma concentration-time curves (AUC) and the mean residence time (MRT) were determined. The patterns of plasma and tissue ivermectin concentrations were similar in the two breeds of animals, however, the AUC and C max levels for plasma and skin were significantly higher in the BB calves. In hair, ivermectin was detected later than in plasma and skin, with the T max ranging between 4 days (Holstein group) and 6 days (BB group). The possible reasons for the significantly higher levels in plasma and skin in BB calves compared to Holstein calves are discussed. #

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Breed differences in the pharmacokinetics of ivermectin administered subcutaneously to Holstein and Belgian Blue calves

Vercruysse

Deprez

Everaert

et al. 2008

Veterinary Parasitology

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“…Marked breed susceptibility and a positive correlation between the antibody titre and the extent of mange have been recorded 8 . The magnitude of the current infection may reflect low immunity in this heifer 4 . No other animal in the vicinity of this case was noticed to have such an infection, which may indicate individual susceptibility rather than unusually high mite virulence.…”

Section: Discussionmentioning

confidence: 97%

Unusual manifestation of a concurrent demodectic and sarcoptic mange in a Zebu-Friesian cross-bred heifer : clinical communication

Hamid¹,

All²,

Ahmed³

et al. 2006

J. S. Afr. Vet. Assoc.

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We describe a rare case of a concurrent demodectic and sarcoptic mange in a 2-year-old heifer in Khartoum, Sudan. The lesions were massive lumps of granulomatous tumour-like dermatitis with thick, nodular folds mainly covering the head, neck and shoulders. Histopathological examination of the lesions revealed the presence of both Demodex bovis and Sarcoptes scabiei. The animal died regardless of the anti-parasitic treatment it received

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“…Os principais artigos publicados sobre sarna psoróptica dos animais domésticos abordam o tema em relação aos caprinos, coelhos, bovinos e ovinos (Bates 1999, Losson et al 1999, van den Broek & Huntley 2003. Debilidade, queda na produção e até mesmo a morte dos hospedeiros são as principais conseqüências do parasitismo nestas espécies.…”

Section: Introdução Introdução Introdução Introduçãounclassified

Relação parasito-hospedeiro entre Psoroptes equi e eqüinos

Tancredi

Faccini

Tancredi³

et al. 2005

Pesq. Vet. Bras.

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The pathology of Psoroptes ovis infestation in cattle with a special emphasis on breed difference

Cited by 37 publications

References 27 publications

Breed differences in the pharmacokinetics of ivermectin administered subcutaneously to Holstein and Belgian Blue calves

Breed differences in the pharmacokinetics of ivermectin administered subcutaneously to Holstein and Belgian Blue calves

Unusual manifestation of a concurrent demodectic and sarcoptic mange in a Zebu-Friesian cross-bred heifer : clinical communication

Relação parasito-hospedeiro entre Psoroptes equi e eqüinos

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