The pathology of postcurettage intrauterine adhesions

Effect of stem cell application on Asherman Syndrome, an experimental rat model

“…The leading pathologic problem in AS is the avascular fibrous connective tissue bands with or without glandular tissue [4]. Hysteroscopic lysis of these adhesions is the main method of treatment.…”

Focus on the Primary Prevention of Intrauterine Adhesions: Current Concept and Vision

“…Finally, fibrotic synechiae form across the entire uterine cavity [ 60 , 61 , 62 , 63 ]. According to Dr. Foix’s classification [ 60 ], three types of IUA have been proposed, including (1) the most common type involves avascular fibrous strands joining the uterine wall, although sometimes, thin-walled telangiectatic vessels can be found in this avascular fibrous strand and calcification or ossification can be found in the stroma area, accompanied with spare and inactive or cystically dilated glands; (2) muscular adhesion composed of collagen bundles, fibrous strips, or muscle with the same characteristics as normal myometrium, of which the percentage of fibrous tissue is more than 50–80% in the biopsy specimens; and (3) a sclerotic, atrophic endometrium [ 60 ]. Han and Du summarized the pathological changes taking place in IUA, including endometrial fibrosis, endometrial scarring, the loss or thinning of the endometrium with different degrees of damage to the basal layer, atrophic glands, a lack of vascular stromal tissue and hypoxia, and a pale microenvironment in the adhesion area [ 62 ].…”

Intrauterine adhesions (Asherman’s syndrome)

“…Over 90% of the cases are caused by curettage [4][5][6]. Usually the trauma has occurred because of excessive bleeding requiring curettage 1 to 4 weeks after a delivery of a term or preterm pregnancy or after an abortion.…”