The Pathology of Peptic Ulceration

Magnus, Hugo

doi:10.1136/pgmj.30.341.131

Cited by 18 publications

(6 citation statements)

References 1 publication

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“…Hebbel [22] described pseudopyloric glands in approximately 20% of patients with gastritis and also noted the presence of pseudopyloric glands adjacent to healing gastric ulcers. Magnus [23] also noted that gastric ulcerations were often completely surrounded by pyloric-type glands.…”

Section: Pseudopyloric Metaplasia In the Stomachmentioning

confidence: 99%

Pyloric metaplasia, pseudopyloric metaplasia, ulcer‐associated cell lineage and spasmolytic polypeptide‐expressing metaplasia: reparative lineages in the gastrointestinal mucosa

Goldenring

2018

The Journal of Pathology

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Summary The gastrointestinal mucosae provide a critical barrier between the external and internal milieu. Thus, damage to the mucosa requires an immediate response to provide appropriate wound closure and healing. Metaplastic lineages with phenotypes similar to the mucous glands of the distal stomach or Brunner’s glands have been associated with various injurious scenarios in the stomach, small bowel and colon. These lineages have been assigned various names including pyloric metaplasia, pseudopyloric metaplasia, Ulcer-associated cell lineage (UACL) and spasmolytic polypeptide-expressing metaplasia (SPEM). A re-examination of the literature on these various forms of mucous cell metaplasia suggests that pyloric type mucosal gland lineages may provide a ubiquitous response to mucosal injury throughout the gastrointestinal tract as well as in the pancreas, esophagus and other mucosal surfaces. While the cellular origin of these putative reparative lineages likely varies in different regions of the gut, their final phenotypes may converge on a pyloric type gland dedicated to mucous secretion. In addition to their healing properties in the setting of acute injury, these pyloric type lineages may also represent precursors to neoplastic transitions in the face of chronic inflammatory influences. Further investigations are needed to determine how discrete molecular profiles relate to the origin and function of pyloric-type metaplasias previously described by histological characteristics in multiple epithelial mucosal systems in the setting of acute and chronic damage.

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Section: Pseudopyloric Metaplasia In the Stomachmentioning

confidence: 99%

Pyloric metaplasia, pseudopyloric metaplasia, ulcer‐associated cell lineage and spasmolytic polypeptide‐expressing metaplasia: reparative lineages in the gastrointestinal mucosa

Goldenring

2018

The Journal of Pathology

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“…As the authors have stated, we determined in experimental animals whether precise antrectomy was more effective in reducing acid secretion than purposefully leaving a 1 inch rim of proximal antrum [2]. In this experiment, the antrum was also vagally denervated.…”

Section: Discussionmentioning

confidence: 99%

Precise antrectomy

Jensen¹,

Badskjaer²,

Andersen³

et al. 1979

World j. surg.

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A follow-up study of 108 patients 2-8 years after precise antrectomy for gastric ulcer showed no ulcer recurrences. The frequency of complications was similar to that following conventional resections. Biopsies taken at gastroscopy at the time of follow-up showed permanent removal of all functioning antral mucosa; no gastrin-producing cells could be recovered from any part of the gastric remnant. There was a close relationship between gastric acid secretion and the incidence and spreading of chronic atrophic gastritis in both resected specimens and biopsies. Following precise antrectomy alone, acid secretion was reduced considerably 3 months postoperatively, and the reduction was unchanged at the time of follow-up. In patients with a high preoperative insulin-stimulated acid secretion, precise antrectomy plus vagotomy reduced acid secretion significantly more than precise antrectomy alone. Besides producing a decrease in acid secretion, the advantage of precise antrectomy appears to be that the target area for recurrent gastric ulcer is permanently removed.

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“…This supposition has later been evidenced by many investigators (Hauser 1883, Konjetzny 1913, 1938, Magnus 1954, Larson et al 1961, Priestley 1962, Oota 1963). Magnus (1954) found unequivocal ulcero-cancer in 1.9 per cent among 421 patients operated on for gastric ulcer. In the present investigation, 2 out of the 5 examined specimens showed increased mitotic activity in the sections containing ulcer, compared with that in the surrounding mucosa.…”

Section: H+ementioning

confidence: 95%

Mitotic Activity of Gastric Mucosa

Llavåg¹

1968

Acta Pathologica Microbiologica Scandinavica

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The Pathology of Peptic Ulceration

Cited by 18 publications

References 1 publication

Pyloric metaplasia, pseudopyloric metaplasia, ulcer‐associated cell lineage and spasmolytic polypeptide‐expressing metaplasia: reparative lineages in the gastrointestinal mucosa

Pyloric metaplasia, pseudopyloric metaplasia, ulcer‐associated cell lineage and spasmolytic polypeptide‐expressing metaplasia: reparative lineages in the gastrointestinal mucosa

Precise antrectomy

Mitotic Activity of Gastric Mucosa

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