The pathology of dyshormonogenetic goitre

Thyroid/Cervical Teratomas in Children: Immunohistochemical Studies for Specific Thyroid Epithelial Cell Markers

“…These observations suggest that an embryological malformation of thyroid follicles in young patients may occur as an isolated lesion or as part of a teratoma. A macroscopic diffuse cystic (spongy) pattern of thyroid follicles has also been described in dyshormonogenetic goiters apparently related to a defect of thyroglobulin synthesis (7). infants have been well documented (9-12), even though the histology in both primary and metastatic lesions showed no frankly malignant elements such as yolk-sac tumor or embryonal carcinoma.…”

Papillary Carcinoma of the Thyroid Arising from Dyshormonogenetic Goiter.

“…The present case is therefore a unique one, in which papillary carcinoma of the thyroid arose in dyshormonogenetic goiter. McGirr et al(1959) reported a case of papillary carcinoma in association with dyshormonogenetic goiter, but the diagnosis was changed to one of a benign condition after a subsequent review by a pathologist (Kennedy, 1969). To the best of our knowledge, the present paper is the first in world literature to report a case of papillary carcinoma associated with dyshormonogenetic goiter.…”

Cytological features of dyshormonogenetic goiter: Case report and review of the literature

“…Coupled with the findings of no uptake on thyroid scintiscan, a misdiagnosis of a follicular neoplasm can be made. 4,5 This problem is further compounded on cytology. Follicular neoplasms are rare in childhood and due credence should be given to the clinical history, raised TSH and low T3 and T4 values, to avoid misdiagnosis.…”

“…The degree of hyperplasia of the gland may be severe enough to suggest a diagnosis, but may prompt an erroneous diagnosis of malignancy at the hands of the inexperienced. 4,5 Although the histology findings are well documented, there is a paucity of cytological findings in dyshormonogenetic goitre. Search of the literature revealed only two reports.…”