The pathology of cystic fibrosis

Sheppard, Mary N.; Nicholson, Andrew G.

doi:10.1054/cdip.2001.0088

Cited by 55 publications

(65 citation statements)

References 63 publications

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“…Among fungal species responsible for fungal infections, a prominent role assign to filamentous fungi such as Aspergillus fumigatus, Scedosporium apiospermum and Exophiala dermatitidis [10,11]. Filamentous fungi are opportunistic microorganisms living in natural environment.…”

Section: Discussionmentioning

confidence: 99%

Fungal Infection of Cystic Fibrosis Patients—Single Center Experience

Garczewska¹,

Kuś²,

Skorupa³

et al. 2016

Advances in Respiratory Medicine

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Introduction: Cystic fibrosis (CF) is the most common monogenetic autosomal recessive disease in the human population. This systemic disease is characterized by changes in multiple organs, mainly in the lung tissue and digestive tract. More than 59% of CF patients become sensitized to fungal spores, mostly Aspergillus fumigatus. 5−15% of CF patients develop allergic bronchopulmonary aspergillosis. The aim of the study was to analyse the occurrence of yeast and filamentous fungi of the respiratory infections in CF patients and evaluation of drug resistance. Material and methods: Between 2006 and 2014, mycological evaluation of 42 patients hospitalized at the National Institute of Tuberculosis and Lung Diseases was carried out. Results: 217 specimens from pulmonary tract were collected from 42 patients with cystic fibrosis. 205 (68%) strains of yeast and 96 (32%) filamentous fungi strains were cultured. The most common mould strain was A. fumigatus -22,2% (67 species). All isolates of filamentous fungi were in vitro 100% susceptible to itraconazole, voriconazole, posaconazole and amphotericin B. Conclusions: A. fumigatus and C. albicans were the most common etiological agents of fungal respiratory pathogens associated with CF patients. A. fumigatus strains were in vitro 100% susceptible to azole and amphotericin B. Two strains of C. albicans and one strain of C.tropicalis were non-susceptible to azole (fluconazole, itraconazole and voriconazole). Scedosporium apiospermum

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Section: Discussionmentioning

confidence: 99%

Fungal Infection of Cystic Fibrosis Patients—Single Center Experience

Garczewska¹,

Kuś²,

Skorupa³

et al. 2016

Advances in Respiratory Medicine

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show abstract

“…Several mechanisms may apply to the development of CFDM. The most prevalent theory is that CFDM is caused by a slow, year-long fibrosis of the exocrine pancreatic tissue with a subsequent strangulation of the islets of Langerhans and thereby reduced number of ␤ cells (20). The second event may be an autoimmune destruction or down-regulation of pancreatic ␤ cells, a similar mechanism found in autoimmune IDDM.…”

Section: Discussionmentioning

confidence: 99%

Relative Increase in IgG Antibodies to Pseudomonas aeruginosa 60-kDa GroEL in Prediabetic Patients with Cystic Fibrosis

Jensen

Johansen

Lanng³

et al. 2001

Pediatr Res

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“…The pulmonary infections are most often caused by Pseudomonas aeruginosa and constitute the primary cause of morbidity and mortality in CF. The bacterial infections are secondary to clogging of the bronchial tree by the abnormally thick mucous secretions characteristic of the genetic lesion that produces CF [1]. Thickened mucous also leads to chronic pancreatitis due to clogging of the exocrine ductal system [1].…”

Section: Introductionmentioning

confidence: 99%

“…The bacterial infections are secondary to clogging of the bronchial tree by the abnormally thick mucous secretions characteristic of the genetic lesion that produces CF [1]. Thickened mucous also leads to chronic pancreatitis due to clogging of the exocrine ductal system [1]. CF patients manifest a high incidence of impaired glucose tolerance (IGT) and CF diabetes mellitus (CFDM) [2].…”

Section: Introductionmentioning

confidence: 99%