The Pathology of Choriocarcinoma

Ober, William B.; Edgcomb, John H.; Price, Edward B.

doi:10.1111/j.1749-6632.1971.tb34943.x

Cited by 82 publications

(23 citation statements)

References 24 publications

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“…CCs may occur after any type of pregnancy in the following proportions: 35–60% after CHMs, 0.5–2% after PHMs, 15–20% after SAs, 1–2% after ectopic pregnancies, and 25–42% after normal pregnancies (40, 41). The diagnosis of CC is based on high hCG levels and both clinical and laboratory evidence demonstrating the presence of tumor cells in distant maternal tissues such as the lung, lower genital tract, brain, liver, kidney, gastrointestinal tract, and spleen.…”

Section: Post-evacuation Hcg Surveillance and Malignanciesmentioning

confidence: 99%

NLRP7 and the Genetics of Hydatidiform Moles: Recent Advances and New Challenges

Slim

Wallace

2013

Front. Immunol.

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NOD-like receptor proteins (NLRPs) are emerging key players in several inflammatory pathways in Mammals. The first identified gene coding for a protein from this family is Nlrp5 and was originally called Mater for “Maternal Antigen That Mouse Embryos Require” for normal development beyond the two-cell stage. This important discovery was followed by the identification of other NLRPs playing roles in inflammatory disorders and of the first maternal-effect gene in humans, NLRP7, which is responsible for an aberrant form of human pregnancy called hydatidiform mole (HM). In this review, we recapitulate the various aspects of the pathology of HM, highlight recent advances regarding NLRP7 and its role in HM and related forms of reproductive losses, and expand our discussion to other NLRPs with a special emphasis on those with known roles in mammalian reproduction. Our aim is to facilitate the genetic complexity of recurrent fetal loss in humans and encourage interdisciplinary collaborations in the fields of NLRPs and reproductive loss.

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Section: Post-evacuation Hcg Surveillance and Malignanciesmentioning

confidence: 99%

NLRP7 and the Genetics of Hydatidiform Moles: Recent Advances and New Challenges

Slim

Wallace

2013

Front. Immunol.

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“…The gross presentation is typically bulky, destructive, single to multiple dark red, shaggy masses with extensive hemorrhage, and variable amount of necrosis (3). Both types of choriocarcinoma have similar gross and microscopic findings.…”

Section: Discussionmentioning

confidence: 99%

Genotyping Diagnosis of Nongestational Choriocarcinoma Involving Fallopian Tube and Broad Ligament

Buza

Rutherford

Hui

2014

International Journal of Gynecological Pathology

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A 22 year-old G1P1 woman presented to the emergency room with clinical impression of "ruptured right adnexal mass" and underwent a right salpingo-oophorectomy to rule out ectopic pregnancy. Instead, gross and microscopic examination revealed a pure choriocarcinoma involving the right fallopian tube and broad ligament. On the basis of the patient's age, recent history of delivery, last menstrual period for 10 weeks, large tumor mass, and possible pelvic lymph node metastasis, the patient promptly started to receive 8 cycles of multiagent chemotherapy regimen with a working diagnosis of high-risk gestational choriocarcinoma. Subsequent DNA genotyping analysis showed that the tumor cells had an identical genetic profile to that of the normal tissue of the patient, therefore establishing a final diagnosis of nongestational choriocarcinoma. Six months after the initial presentation, a second surgery was performed to remove a persistent right para-adnexal mass, which showed only necrotic tissue upon microscopic examination. The patient received 1 additional cycle of multiagent chemotherapy. She was alive without evidence of recurrence 26 months after the initial diagnosis.

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“…Clinically, the most remarkable feature of choriocarcinoma is that this highly aggressive malignant tumour is now eminently curable. Indeed, so successful may treatment be that, if the uterus is preserved, a subsequent normal gestation is possible (Bagshawe, 1969 been so well described in the past (Teacher, 1903;Ewing, 1910;Park and Lees, 1950;Novak and Seah, 1954a;Ober et al, 1971;Park, 1971) that little more than a brief outline will be given here. Grossly there is remarkable consistency in the findings.…”

Section: Choriocarcinomamentioning

confidence: 99%

“…Both Marchand and Ewing commented on the widespread permeation of the uterine musculature by giant mononuclear cells apparently derived from the syncytium; in Ewing's opinion the prognosis was much more favourable than that of typical choriocarcinoma. Others do not consider the lesion to be a true neoplasm (Novak and Seah, 1954b;Ober et al, 1971;Elston and Bagshawe, 1972b) but rather an abnormal persistence of placental site cells. Nevertheless, both clinically and histologically there are features which may closely mimic choriocarcinoma.…”

Section: Simple or Suspicious Trophoblastmentioning

confidence: 99%

The histopathology of trophoblastic tumours

Elston¹

1976

J Clin Pathol

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The Pathology of Choriocarcinoma

Cited by 82 publications

References 24 publications

NLRP7 and the Genetics of Hydatidiform Moles: Recent Advances and New Challenges

NLRP7 and the Genetics of Hydatidiform Moles: Recent Advances and New Challenges

Genotyping Diagnosis of Nongestational Choriocarcinoma Involving Fallopian Tube and Broad Ligament

The histopathology of trophoblastic tumours

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