The Pathology of Cardiovascular Interventions and Devices for Coronary Artery Disease, Vascular Disease, Heart Failure, and Arrhythmias

Buja, L. Maximilian; Schoen, Frederick J.

doi:10.1016/b978-0-12-420219-1.00032-x

Cited by 9 publications

(2 citation statements)

References 168 publications

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“…The intermediate hypocellular state (Buja & Schoen, ; Cox, Chiasson, & Gotlieb, ) seen in treated SVGs by 30 days may have played a role in the overall remodeling response. Decellularized ECM used as a tissue‐engineering scaffold has been shown to foster rapid and functional host tissue remodeling with properties tailored to the site of implantation (Brown & Badylak, ).…”

Section: Discussionmentioning

confidence: 99%

Functional remodeling of an electrospun polydimethylsiloxane‐based polyether urethane external vein graft support device in an ovine model

El-Kurdi¹,

Soletti²,

McGrath³

et al. 2019

J Biomedical Materials Res

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Saphenous vein graft (SVG) failure rates are unacceptably high, and external mechanical support may improve patency. We studied the histologic remodeling of a conformal, electrospun, polydimethylsiloxane-based polyether urethane external support device for SVGs and evaluated graft structural evolution in adult sheep to 2 years. All sheep (N = 19) survived to their intended timepoints, and angiography showed device-treated SVG geometric stability over time (30, 90, 180, 365, or 730 days), with an aggregated graft patency rate of 92%. There was minimal inflammation associated with the device material at all timepoints. By 180 days, treated SVG remodeling was characterized by minimal/nonprogressive intimal hyperplasia; polymer fragmentation and integration; as well as the development of a neointima, and a confluent endothelium. By 1-year, the graft developed a media-like layer by remodeling the neointima, and elastic fibers formed well-defined structures that subtended the neo-medial layer of the remodeled SVG. Immunohistochemistry showed that this neo-media was populated with smooth muscle cells, and the intima was lined with endothelial cells. These data suggest that treated SVGs were structurally remodeled by 180 days, and developed arterial-like features by 1 year, which continued to mature to 2 years. Device-treated SVGs remodeled into arterial-like conduits with stable long-term performance as arterial grafts in adult sheep. K E Y W O R D S biomaterial remodeling, environmental stress cracking, external stent, polydimethylsiloxane polyether urethane, saphenous vein graft

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Section: Discussionmentioning

confidence: 99%

Functional remodeling of an electrospun polydimethylsiloxane‐based polyether urethane external vein graft support device in an ovine model

El-Kurdi¹,

Soletti²,

McGrath³

et al. 2019

J Biomedical Materials Res

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show abstract

“…Although this cautions the use of OCT in tortuous segments in the early remodeling, it should be noted that the tortuosity is progressive pathologic process is ongoing that could ultimately cause occlusions, which is in line with both preclinical and clinical evidence. 41,48 Quantitative angiography revealed that RVGs maintained an overall uniform and nondilating lumen throughout the duration of the study. This is in stark contrast to the SVGs in this study, and as also reported in previous work, which showed that SVGs exhibited progressively increasing dilation over time, doubling the initial diameter by 1 year.…”

mentioning

confidence: 96%

1-Year Patency of Biorestorative Polymeric Coronary Artery Bypass Grafts in an Ovine Model

Ono

Kageyama

O’Leary

et al. 2023

JACC: Basic to Translational Science

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Vascular Tissue Engineering: Pathological Considerations, Mechanisms, and Translational Implications

Schöen¹,

Fioretta²,

Mallone³

et al. 2020

Tissue-Engineered Vascular Grafts

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The Pathology of Cardiovascular Interventions and Devices for Coronary Artery Disease, Vascular Disease, Heart Failure, and Arrhythmias

Cited by 9 publications

References 168 publications

Functional remodeling of an electrospun polydimethylsiloxane‐based polyether urethane external vein graft support device in an ovine model

Functional remodeling of an electrospun polydimethylsiloxane‐based polyether urethane external vein graft support device in an ovine model

1-Year Patency of Biorestorative Polymeric Coronary Artery Bypass Grafts in an Ovine Model

Vascular Tissue Engineering: Pathological Considerations, Mechanisms, and Translational Implications

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