The Pathology of Artificial Hearts and Ventricular Assist Devices

Coumbe, A.; Graham, Timothy R.

doi:10.1007/978-3-642-76846-0_5

Cited by 2 publications

(1 citation statement)

References 57 publications

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“…Polyurethanes find widespread use as construction biomaterials for catheters, blood pumps (Coumbe and Graham, 1994), and other medical devices, which are temporarily in contact with the circulation. The physical/mechanical properties of polyurethanes, including their high flexural strength and excellent resistance to flex fatigue, are particularly suitable for these applications (Boretos, 1981;Lelah and Cooper, 1986;Herring et al, 1994;Müller and Dasbach, 1994).…”

Section: Introductionmentioning

confidence: 99%

Platelet adhesion studies on dipyridamole coated polyurethane surfaces

Aldenhoff

Koole²

2003

eCM

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Surface modification of polyurethanes (PUs) by covalent attachment of dipyridamole (Persantin ®) is known to reduce adherence of blood platelets upon exposure to human platelet rich plasma (PRP). This effect was investigated in further detail. First platelet adhesion under static conditions was studied with four different biomaterial surfaces: untreated PU, PU immobilised with conjugate molecule 1, PU immobilised with conjugate molecule 2, and PU immobilised with conjugate molecule 3. In PU immobilised with 1 dipyridamole is directly linked to the surface, in PU immobilised with 2 there is a short hydrophilic spacer chain in between the surface and the dipyridamole, while conjugate molecule 3 is merely the spacer chain. Scanning electron microscopy (SEM) was used to characterise platelet adhesion from human PRP under static conditions, and fluorescence imaging microscopy was used to study platelet adhesion from whole blood under flow. SEM experiments encompassed both density measurements and analysis of the morphology of adherent platelets. In the static experiments the surface immobilised with 2 showed the lowest platelet adherence. No difference between the three modified surfaces emerged from the flow experiments. The surfaces were also incubated with washed blood platelets and labeled with Oregon-Green Annexin V. No capture of Oregon-Green Annexin V was seen, implying that the adhered platelets did not expose any phosphatidyl serine at their exteriour surface.

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Section: Introductionmentioning

confidence: 99%

Platelet adhesion studies on dipyridamole coated polyurethane surfaces

Aldenhoff

Koole²

2003

eCM

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Cardiovascular applications of biomaterials and implants–an overview

Black

1995

Journal of Medical Engineering & Technology

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This paper was originally commissioned by the UK Department of Health as a contribution to the work of its Biomaterials and Implants Research Advisory Group. This group was set up under the Chairmanship of Professor Sir Colin Berry with the following terms of reference: (i) to identify recent advances in the field of biomaterials; (ii) to consider the future contribution of biomaterials in improving human health; (iii) to advise the Standing Group on Health Technology in areas where developments and assessment are needed; and (iv) to report to the Director of Research and Development (Professor Sir Michael Peckham) by October 1995. The cardiovascular field was one of several areas in biomaterials/implants considered by the Advisory Group. Amongst other areas considered were orthopaedics, dentistry, urology, wound repair and ophthalmology. Additionally, consideration was also given to such topics as chemical and biochemical sensors, drug release, hydrogels, membranes and artificial organs. The final report of the Advisory Group will be published at the end of this year. However, the Department has agreed that individual working papers such as the present one can be published independently in appropriate scientific journals.

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The Pathology of Artificial Hearts and Ventricular Assist Devices

Cited by 2 publications

References 57 publications

Platelet adhesion studies on dipyridamole coated polyurethane surfaces

Platelet adhesion studies on dipyridamole coated polyurethane surfaces

Cardiovascular applications of biomaterials and implants–an overview

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