The pathological significance and potential mechanism of ACLY in cholangiocarcinoma
Xiaoyan Sun,
Xiaofang Zhao,
Senyan Wang
et al.
Abstract:Background and aimCholangiocarcinoma (CCA) is a rare cancer, yet its incidence and mortality rates have been steadily increasing globally over the past few decades. Currently, there are no effective targeted treatment strategies available for patients. ACLY (ATP Citrate Lyase), a key enzyme in de novo lipogenesis, is aberrantly expressed in several tumors and is associated with malignant progression. However, its role and mechanisms in CCA have not yet been elucidated.MethodsThe expression of ACLY in CCA was a… Show more
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