The pathological role and prognostic impact of miR-181 in acute myeloid leukemia

Weng, Hengyou; Lal, Kumar; Yang, Frank; Chen, Jianjun

doi:10.1016/j.cancergen.2014.12.006

Cited by 50 publications

(56 citation statements)

References 44 publications

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“…Several studies have identified the miR-181 members as regulators of myeloid differentiation and AML. In fact, over-expression in particular of miR-181a was observed in both AML patients 14,18,49,60 compared to normal controls and the entire family in the high risk MDS patients compared to low risk MDS patients. 15 Since the classification of high risk MDS is partially dependent upon the percentage of blasts and since AML by definition has greater than 20% blasts, the expression of miR-181 family members might correlate simply with increased blasts.…”

Section: Discussionmentioning

confidence: 95%

MicroRNAs and tRNA-derived fragments predict the transformation of myelodysplastic syndromes to acute myeloid leukemia

Guo

Strickland

Mohan

et al. 2017

Leukemia & Lymphoma

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Myelodysplastic syndromes (MDS) are clonal hematopoietic disorders of the elderly that carry an increased risk of progression to acute myeloid leukemia (AML). Since small non-coding RNAs (sRNAs), including microRNA (miRNAs), act as regulators of cellular differentiation, we hypothesized that changes to sRNAs might be implicated in the progression of MDS to AML. We conducted sRNA sequencing on three sets of patients: Group A (MDS patients who never progressed to AML); Group B (MDS patients who later progressed to an AML); and Group C (AML patients with myelodysplasia-related changes, including patients with a known preceding diagnosis of MDS). We identified five miRNAs that differentiated Groups A and B, independent of bone marrow blast percentage, including three members of the miR-181 family, as well as differential patterns of miRNA isoforms (isomiRs) and tDRs. Thus, we have identified sRNA biomarkers that predict MDS cases that are likely to progress to AML.

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Section: Discussionmentioning

confidence: 95%

MicroRNAs and tRNA-derived fragments predict the transformation of myelodysplastic syndromes to acute myeloid leukemia

Guo

Strickland

Mohan

et al. 2017

Leukemia & Lymphoma

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“…MiR-181 family plays a significant role in T-cell differentiation and development in the thymus [23, 27, 35, 36, 41]. MiR-181a was recently shown to be consistently overexpressed in T-cell leukemia and lymphoma [39].…”

Section: Discussionmentioning

confidence: 99%

“…The miR-181 family includes four members (miR-181a-d) produced from three polycistronic clusters [23, 35]. MiR-181 is dysregulated in many cancers [36–38], including function as a tumor suppressor in CLL [39], and as an oncogene in breast [40] and colorectal cancers [36]. MiR-181 also plays a significant role in T-cell development and differentiation [23, 27, 35, 36, 41].…”

Section: Introductionmentioning

confidence: 99%

“…MiR-181 is dysregulated in many cancers [36–38], including function as a tumor suppressor in CLL [39], and as an oncogene in breast [40] and colorectal cancers [36]. MiR-181 also plays a significant role in T-cell development and differentiation [23, 27, 35, 36, 41]. MiR profiles are increasingly used in diagnosis and prognostication of human cancers including CTCL [42–44].…”

Section: Introductionmentioning

confidence: 99%

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MicroRNA-181 contributes to downregulation of SAMHD1 expression in CD4+ T-cells derived from Sèzary syndrome patients

et al. 2017

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Sézary syndrome (SS) is a rare subtype of cutaneous T-cell lymphoma (CTCL) that is characterized by aggressive spread of neoplastic CD4+ T-cells from the skin into the bloodstream with metastasis to visceral organs. The deoxynucleoside triphosphohydrolase SAMHD1 is highly expressed in normal CD4+ T-cells, while its expression is down-regulated in CD4+ T-cells from SS patients. MicroRNA (miR) dysregulation is an important epigenetic mechanism in the pathogenesis and progression of SS. MiR-181 has been shown to inhibit SAMHD1 expression in cell lines and was identified as an important prognostic biomarker in CTCL. However, whether SAMHD1 is down-regulated by miR-181 in primary CD4+ T-cells of SS patients is unknown. Compared to normal CD4+ T-cells, SAMHD1 protein expression is significantly reduced in transformed CD4+ T-cell lines and CD4+ T-cells from SS patients, which inversely correlates with increased miR-181 levels in these cells. Over-expression of miR-181b in primary CD4+ T-cells from healthy donors significantly decreased SAMHD1 protein level, but not mRNA level. In contrast, inhibition of miR-181 in a CD4+ T-cell line significantly increased the level of SAMHD1 protein expression. Our results demonstrate that miR-181 is an important regulator of SAMHD1 protein expression in neoplastic CD4+ T-cells, likely through a mechanism of translational inhibition.

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“…Dysregulation of the miR-181 family was also shown to be closely associated with the pathogenesis and prognosis of AML. Additionally, members of the miR-181 family were demonstrated to mediate several cancer-related pathways, such as the RAS/MAPK pathway, thus acting as tumor suppressors in myeloid leukemogenesis [29,30]. Therefore, targeting the circ-ANAPC7-miR-181 axis may be a novel therapeutic approach for AML.…”

Section: Cellular Physiology and Biochemistrymentioning

confidence: 99%

Circ-ANAPC7 is Upregulated in Acute Myeloid Leukemia and Appears to Target the MiR-181 Family

Chen

Liu

et al. 2018

Cell Physiol Biochem

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Background/Aims: Circular RNAs (circRNAs) are a family of novel non-coding RNAs associated with various diseases, especially cancer. Recent studies have demonstrated that circRNAs participate in pathogenesis mainly by acting as microRNA (miRNA) sponges. The expression profile of circRNAs in acute myeloid leukemia (AML) has rarely been reported. Methods: Profiles of circRNAs were analyzed using an Arraystar human circRNA microarray with 5 bone marrow samples from patients with newly diagnosed AML and 5 from patients with iron-deficiency anemia. Quantitative reverse transcription PCR was used to validate the expression pattern of circRNAs. Furthermore, circRNA–miRNA network, Gene Ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were applied. Results: CircRNA microarray analysis revealed that 698 circRNAs were differentially expressed in AML patients, with 282 circRNAs found to be upregulated and 416 to be downregulated. Quantitative reverse transcription PCR showed that circ-ANAPC7 was significantly upregulated in AML. Bioinformatics analysis predicted that circ-ANAPC7 acts as a sponge for the miR-181 family, KEGG analysis revealed that it is associated with cancer-related pathways, and GO analysis indicated that most of its target genes are involved in biological processes. Conclusions: These findings show that circ-ANAPC7 is a promising biomarker for AML, and that it might participate in AML pathogenesis by acting as a sponge for the miR-181 family.

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The pathological role and prognostic impact of miR-181 in acute myeloid leukemia

Cited by 50 publications

References 44 publications

MicroRNAs and tRNA-derived fragments predict the transformation of myelodysplastic syndromes to acute myeloid leukemia

MicroRNAs and tRNA-derived fragments predict the transformation of myelodysplastic syndromes to acute myeloid leukemia

MicroRNA-181 contributes to downregulation of SAMHD1 expression in CD4+ T-cells derived from Sèzary syndrome patients

Circ-ANAPC7 is Upregulated in Acute Myeloid Leukemia and Appears to Target the MiR-181 Family

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