The pathological complete response and secreted protein acidic and rich in cysteine expression in patients with breast cancer receiving neoadjuvant nab‑paclitaxel chemotherapy

Nakazawa, Yuko; Nakazawa, Shozo; Kurozumi, Sasagu; Ogino, Misato; Koibuchi, Yukio; Odawara, Hiroki; Oyama, Tetsunari; Horiguchi, Jun; Fujii, Takaaki; Shirabe, Ken

doi:10.3892/ol.2020.11354

Cited by 13 publications

(16 citation statements)

References 47 publications

(72 reference statements)

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“…The SPARC glycoprotein has a high affinity for albumin, and macrophage-derived SPARC contributes to metastasis by acting at the step of integrin-mediated migration of invasive cells 15 . Previously, SPARC mRNA expression was reported as a predictor of a pathological complete response after neoadjuvant nab-paclitaxel therapy 16 . Our study underscored the relationship between SPARC expression and invasive regions, which may be clinically important for treating breast cancer.…”

Section: Discussionmentioning

confidence: 99%

Efficient prediction of a spatial transcriptomics profile better characterizes breast cancer tissue sections without costly experimentation

Monjo

Koido

Nagasawa

et al. 2021

Preprint

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Spatial transcriptomics is an emerging technology requiring costly reagents and considerable skills, limiting the identification of transcriptional markers related to histology. Here, we show that predicted spatial gene-expressions in unmeasured regions and tissues can enhance biologists' histological interpretations. We developed the Deep learning model for Spatial gene Clusters and Expression, DeepSpaCE and confirmed its performance using the spatial-transcriptome profiles and immunohistochemistry images of consecutive human breast cancer tissue sections. For example, the predicted expression patterns of SPARC, an invasion marker, highlighted a small tumor-invasion region that is difficult to identify using raw data of spatial transcriptome alone because of a lack of measurements. We further developed semi-supervised DeepSpaCE using unlabeled histology images and increased the imputation accuracy of consecutive sections, enhancing applicability for a small sample size. Our method enables users to derive hidden histological characters via spatial transcriptome and gene annotations, leading to accelerated biological discoveries without additional experiments.

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Section: Discussionmentioning

confidence: 99%

Efficient prediction of a spatial transcriptomics profile better characterizes breast cancer tissue sections without costly experimentation

Monjo

Koido

Nagasawa

et al. 2021

Preprint

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“…The details extracted from the database were age, histological type, primary tumor size (T factor), axillary lymph node status, estrogen receptor (ER) and progesterone receptor (PgR) expression status, the human epidermal growth factor receptor 2 (HER2) status of the primary tumor, and the use of adjuvant chemotherapy or hormone therapy. The ER and PgR statuses were assessed by the Allred score ≥3 indicating ER and PgR positivity [ 15 , 16 ]. HER2 overexpression was determined by an immunohistochemistry (IHC) analysis and a fluorescence in situ hybridization (FISH) analysis with IHC 3+ or IHC 2+/FISH+ indicating HER2 positivity [ 16 ].…”

Section: Methodsmentioning

confidence: 99%

“…The ER and PgR statuses were assessed by the Allred score ≥3 indicating ER and PgR positivity [ 15 , 16 ]. HER2 overexpression was determined by an immunohistochemistry (IHC) analysis and a fluorescence in situ hybridization (FISH) analysis with IHC 3+ or IHC 2+/FISH+ indicating HER2 positivity [ 16 ].…”

Section: Methodsmentioning

confidence: 99%

Oncological safety of immediate breast reconstruction with skin- or nipple-sparing mastectomy: the value of tumor-to-dermis distance measured by preoperative ultrasonography

et al. 2021

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Background Immediate breast reconstruction with skin-sparing (SSM) or nipple-sparing mastectomy (NSM) has become a common procedure. In this study, we evaluated the distance between breast tumor and skin in a series of patients undergoing IBR as it relates to oncologic safety, namely, the incidence of recurrence. Methods The distance of the tumor to the dermis, rather than the outer layer of skin, was the key parameter of our preoperative ultrasound measurements. Our data set comprised the cases of 171 patients and 181 breasts with breast cancer that had undergone two-stage breast reconstruction by expander. The median age of the patients was 47 years (25–75 years). The overall median follow-up period was 47.1 months (8.8–125.3 months). Eighty-five breasts underwent IBR with SSM/NSM; the others underwent conventional mastectomy. Results Among the total of 181 reconstructed breast mounds, the locoregional recurrence rate was 1.1% (2 breasts) with no cases of skin flap recurrence or skin flap necrosis. The tumor-to-dermis distance of cases with skin preservation (NSM/SSM) was significantly less than that of cases with conventional mastectomy (3.8 ± 2.7 mm vs 5.2 ± 2.4 mm). In cases with invasive carcinoma, all cases whose tumor-to-dermis distance was less than 2 mm underwent resection of the skin immediately overlying the tumor. Conclusions Our results suggested that a 2-mm distance between the dermis and tumor on ultrasound evaluation is sufficient for the use of this tissue as a skin flap in SSM/NSM procedures. Our study indicated that immediate breast reconstruction with SSM/NSM can be an oncologically safe surgical option for breast cancer. However, we recommend that resection of the skin overlying the tumor be performed in cases with invasive breast cancer in which the tumor-to-dermis distance is less than 2 mm. Trial registration Patients in this study were retrospectively registered. This study design was approved by our Clinical Ethics Committee (No 1297) (http://ciru.dept.showa.gunma-u.ac.jp/guidance/storage-sample/list.html).

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“…SPARC as a chemotactic factor might promote cell migration towards bone in breast and prostate tumors. 36,37 A study has also documented that secondary tumor sites SPARC expression is increased than that of the primary tumors. 38…”

Section: Bone Metastasismentioning

confidence: 99%

“…Increased chances of pathological complete remission in response to chemotherapy is achieved when primary tumor has high SPARC expression. 36…”

Section: Response To Chemotherapy and Radiationmentioning

confidence: 99%

SPARC in Breast Carcinomas: A Critical Review

Mughal¹,

Khalid²,

Naseem³

et al. 2020

BIOMEDICA

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Breast cancer is the second most common cancer in the world according to World Health Organization statistics. Among Asian countries, Pakistan has the highest incidence of breast cancer. The normal breast development is interplay between various hormones and transcription factors. Estrogen receptor, progesterone receptor and human epidermal growth factor are being utilized for the targeted therapy of breast cancers. However, there is further need of research to improve the treatment strategies in this regard. Secreted Protein Acidic and Rich in Cysteine (SPARC) is a new biomarker and therapeutic target in breast cancer as well as other tumor types. It's a matricellular protein whose main function is to mediate interactions between cells and their extracellular surrounding during morphogenesis, tissue remodeling and angiogenesis. Therefore, SPARC enables tumor cells to interact with stromal cells and the extracellular matrix. Regarding breast carcinoma, SPARC has been identified as an important negative regulator of tumor characteristics associated with poor prognosis.

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The pathological complete response and secreted protein acidic and rich in cysteine expression in patients with breast cancer receiving neoadjuvant nab‑paclitaxel chemotherapy

Cited by 13 publications

References 47 publications

Efficient prediction of a spatial transcriptomics profile better characterizes breast cancer tissue sections without costly experimentation

Efficient prediction of a spatial transcriptomics profile better characterizes breast cancer tissue sections without costly experimentation

Oncological safety of immediate breast reconstruction with skin- or nipple-sparing mastectomy: the value of tumor-to-dermis distance measured by preoperative ultrasonography

SPARC in Breast Carcinomas: A Critical Review

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