The Pathological and Clinical Aspects of Thrombo-Angiitis Obliterans

Immunohistochemical analysis of arterial wall cellular infiltration in Buerger's disease (endarteritis obliterans)

“…1 He considered acute inflammation and occlusive thrombosis of arteries and veins to be the characteristic lesions of the clinicopathologic entity. 10,11 In the long period since Buerger reported thromboangiitis obliterans, imprecise and conflicting clinical and pathologic criteria have caused much confusion and uncertainty in diagnosis. Tissue specimens seldom included the acute phase lesion, which Buerger viewed as essential for diagnosis.…”

“…Tissue specimens seldom included the acute phase lesion, which Buerger viewed as essential for diagnosis. 1,11,12 Chronic lesions, often said to be the least distinctive of the three stages of Buerger's disease, may be merely nonspecific residual evidence of arterial occlusion. 3,4,13 We examined all three stages by means of immunohistochemistry to determine which stage (acute, subacute, or chronic) possesses distinctive features.…”

Endarteritis Obliterans in the Pathogenesis of Buerger’s Disease From the Pathological and Immunohistochemical Points of View

“…2 He considered acute inflammation and occlusive thrombosis of both arteries and veins to be the characteristic lesions of the clinicopathologic entity. 3, 4 In 1878, Winiwarter had reported a case of a 57-year-old man who underwent a below-the-knee amputation because of right foot gangrene with rheumatic-like pain. 5 In Tokyo, Japan, Haga reported clinical features of 10 cases and pathological findings of 13 specimens in 1889, 6 and 9 years later, he contributed a paper with additional cases of spontaneous gangrene to Virchow's Archive, and Virchow commented on the significance of syphilitic lesion in the vessel.…”