The Pathogenic Role of Corynebacterium Acnes in Acne Vulgaris

Kirschbaum, Jerome Ormond; Kligman, Albert M.

doi:10.1001/archderm.1963.01590240156026

Cited by 72 publications

(18 citation statements)

References 4 publications

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“…The production of inflammatory lesions when P . acnes organisms are injected into sterile steatocystomas (Kirschbaum and Kligman, 1963) and the reduction in severity of acne when the numbers of P. acnes are reduced by systemic tetracycline (Lane and Williamson, 1969;Marples and Kligrnan, 1971) indicate involvement of this organism in the development of acne lesions. Whether S. epidermidis is involved in pathogenesis or not is unknown.…”

Section: Plate I11mentioning

confidence: 99%

Intergeneric and Intrageneric Inhibition Between Strains of Propionibacterium Acnes and Micrococcaceae, Particularly Staphylococcus Epidermidis, Isolated from Normal Skin and Acne Lesions

Holland

Cunliffe²,

Eady

1979

Journal of Medical Microbiology

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P. acnes; (2) to determine whether strains of P . acnes produce inhibitors of S. epidermidis and of P. acnes; and (3) to determine the frequency of occurrence of inhibitory strains on normal and acne skin.MATERIALS AND METHODS Media. Nutrient Broth Number 2, Blood Agar Base, and Reinforced Clostridial Medium were obtained from Oxoid Limited, Southwark Bridge Road, London, SE1 9HF. Brain Heart Infusion Agar was purchased from Difco Laboratories, PO Box 14B, Central Avenue, West Molesey, Surrey.Source of bacteria. All strains of bacteria were isolated from the faces or backs of 44 subjects attending the acne clinic at the Leeds General Infirmary or from employees of the Department of Microbiology, University of Leeds (table I). All subjects were in the age range 15-30 years, with the exception of one patient aged 39 who had severe acne. There were 29 females and 15 males. Patients were graded according to a modification of the scheme of Burton et al. (1971), increasing the number of grades within the ' low acne ' group.Only subjects without evidence of acne on face, back and chest were regarded as controls.Samples were obtained from the skin surface with swabs soaked in nutrient broth. Organisms were released from the swab by agitation in 10 ml of nutrient broth on a rotamixer for 5 s; 0.1-ml volumes of the undiluted and tenfold diluted samples were plated out on heated blood agar (7 % v/v horse blood, Oxoid) for isolation of Micrococcaceae and on Brain Heart Infusion Agar with 0.3 % glucose added for isolation of P. acnes. Plates were incubated at 37"C, for 2 days aerobically for Micrococcaceae and 7 days anaerobically for P. acnes in an atmosphere of H2 plus 10 % C02 in Baird and Tatlock cold-catalyst anaerobic jars.Strains for use in inhibition tests were selected on the basis of predominant colonial types of either P. acnes or Micrococcaceae, verified by Gram staining and coded as follows: M = Micrococcaceae; P = Propionibacterium; F = isolated from face; B = isolated from back; hence MF1 , MB2, PF1 , PB2, etc.

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Section: Plate I11mentioning

confidence: 99%

Intergeneric and Intrageneric Inhibition Between Strains of Propionibacterium Acnes and Micrococcaceae, Particularly Staphylococcus Epidermidis, Isolated from Normal Skin and Acne Lesions

Holland

Cunliffe²,

Eady

1979

Journal of Medical Microbiology

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“…They observed a decrease in P. acnes in pustules and hypothesized its rapid phagocytation after the comedo bursts [238]. Kirschbaum and Kligman [239] examined whether P. acnes could proliferate in certain cysts and provoke their rupture. The cysts of 3 patients injected with P. acnes remained quiescent for a week before they became tender, swollen and reddened.…”

Section: From Acne Microbacillus To P Acnes: Facts Controversies Anmentioning

confidence: 99%

“…The cysts of 3 patients injected with P. acnes remained quiescent for a week before they became tender, swollen and reddened. Regarding comedo as a cyst-like lesion which contents are similar, the authors speculated that its transformation into a pustule or nodule might be the consequence of a ‘sustained bacterial multiplication' of P. acnes [239]. This did not happen when cocci were injected and comedones induced in humans by topical application of coal tar that harbor very few P. acnes did not undergo inflammatory breakdown.…”

Section: From Acne Microbacillus To P Acnes: Facts Controversies Anmentioning

confidence: 99%

Acne Pathogenesis: History of Concepts

Tilles¹

2014

Dermatology

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From the first reliable descriptions of acne in the early 19th century, dermatologists recognized it as a disease of the pilosebaceous follicle. Until the middle of the 20th century, they hypothesized that seborrhoea, follicular keratosis and microorganisms could be individually responsible for the acne lesions. Inflammation was only regarded as the final and inescapable step of the acne process. Although the importance of these factors has been reevaluated, recent works still regarded them as mandatory. In the 1970s, the onset of isotretinoin dramatically improved acne management. It also provided great opportunities for a better understanding of the pathogenic factors of acne. This study analyzes their genesis and development from the seminal contributions until recent advances.

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“…Horn ma te ri al oder Haar bestand tei le fa chen die Ent zün dung im Sinne ei ner Fremd körper re ak ti on noch weiter an. Wäh rend lan ge Zeit die Ent zün-dung nur als Fol ge der 3 an de ren pa tho gene ti schen Fak to ren, ins be son de re der bakte ri el len Stoff wech sel pro duk te an ge se hen wur de [15], er gibt sich aus neue ren Be funden, dass bei Ak ne pa ti en ten schon von vor ne he rein eine ent zünd li che Re ak ti onsbe reit schaft des Fol li kels be ste hen kann [13]. Es wird an ge nom men, dass um den Fol li kel an ge sie del te Leu ko zy ten, ins be sonde re T-Lym pho zy ten, über die Se kre ti on von Ent zün dungs me dia to ren zu ei ner initi a len Ko me do nen bil dung bei tra gen und so den Bo den für die Ent ste hung der Akne be rei ten.…”

Section: Im Mu No Lo Gi Sche Fak To Ren Und Ent Zün Dungunclassified