The Pathogenesis of Vascular Disease

Fleming-Harrington Redistribution Wash-in Washout (FHRWW): The Platinum Standard for Nuclear Cardiology

“…Even though manufactures support the use of 128 x 128 matrix as giving greater detail, the use of the 128 x 128 matrix reported a greater decay in the isotope than is physically possible suggesting that information is lost; perhaps as a result of "modulation transfer function" (a concept well known to photographers and imaging engineers). During the second and third Section of our study we looked at the timing sequence, which would yield the most valuable information, not only regarding detecting changes in radioactivity with cardiac tissue, but the ability to detect markers of inflammation (Fleming 1999c, 2000c, 2003e, 2008, Kern 2006. Our previous findings clearly demonstrated the importance of looking for markers of inflammation when detectable, i.e.…”

“…This approach not only gave us a greater insight as to the cause of angina, viz. regional blood flow differences (Fleming 2003d); but, it allowed us to additionally see for the first time detectable evidence of an activated thymus gland (Fleming 2003e) with enlargement and increased isotope uptake associated with coronary artery disease/inflammation (Fleming 1999c(Fleming , 2003e, 2008a and providing further evidence of underlying coronary artery disease. This same state physiologic approach allowed us to compare images of the heart taken at 5 minutes and 60 minutes following pharmacologic www.intechopen.com…”

“…While diagnostic testing and decision making in the treatment of atherosclerotic coronary artery disease (ASCAD/CAD) tends to revolve around evidence of anatomic [cardiac catheterization (Fleming1991b), coronary computed tomography, intravascular ultrasound (Taki 2001, St Goar 1991, et cetera] disease, it has been well established that this inflammatory (Fleming 1999c(Fleming , 2000c process may smolder for years and that up to 85% of all myocardial infarctions occur with < 30% diameter narrowing. It is; therefore, important for us to look for new ways to uncover this smoldering inflammatory disease process when intervention may be more beneficial to the patient and potentially less costly to the patient and society at a time when health care costs are a major issue.…”

Mitochondrial Uptake of Sestamibi Distinguishes Between Normal, Inflammatory Breast Changes, Pre-Cancers, and Infiltrating Breast Cancer

“…The importance of immunologic responses to disease in the human body is present in both heart disease 30 and cancer. The role in tumors includes natural killer cells, cytokines, interleukins, and so on.…”

Koroner Arter Hastalığı

“…Ateroskleroz 3 temel sürecin sonucu olarak ortaya çıkmaktadır [5,11,12]. Bunlar intimal düz kas hücrelerinin birikimine eşlik eden değişken sayıda makrofaj ve T-lenfosit birikimi; düz kas hücre proliferasyonuna sekonder kollajen, elastik lifler ve proteoglikanları da içeren büyük miktarda bağ dokusu matriksinin oluşumu; ve bağ dokusunda ve hücrelerin içerisinde serbest kolesterol ve esas olarak da kolesterol ester formunda lipit birikimi olup, bu süreçler patolojik intimal kalınlaş-ma ile sonuçlanır [5].…”