The Pathogenesis of Splenomegaly in Hypertension of the Portal Circulation; “Congestive Splenomegaly”

Moschcowitz, Eli

doi:10.1097/00005792-194805000-00002

Cited by 46 publications

(13 citation statements)

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“…Traditionally, splenomegaly was thought to be due to passive splenic congestion, as a mere consequence of the rise in portal venous pressure and the increased resistance to splenic blood outflow [4]. More recently, the role of tissue hyperplasia besides congestion has also been suggested [5].…”

Section: Introductionmentioning

confidence: 99%

Relevance of the mTOR signaling pathway in the pathophysiology of splenomegaly in rats with chronic portal hypertension

Mejías¹,

García-Pras²,

Gallego³

et al. 2010

Journal of Hepatology

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Section: Introductionmentioning

confidence: 99%

Relevance of the mTOR signaling pathway in the pathophysiology of splenomegaly in rats with chronic portal hypertension

Mejías¹,

García-Pras²,

Gallego³

et al. 2010

Journal of Hepatology

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“…Probably because the findings tend to be repetitive and non specific. One classical analysis of 86 spleens, representing chronic cases of portal hypertension due to different etiologies, showed similar morphologic changes (Moschowitz 1948). These changes have been characterized as sclerocongestive or fibro-congestive, implying that there is progressive fibrosis of the splenic cords due to the prolonged congestion and dilatation of the venous sinuses.…”

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confidence: 99%

Pathology of the spleen in hepatosplenic schistosomiasis. Morphometric evaluation and extracellular matrix changes

Freitas

Barbosa

Fernandes

et al. 1999

Mem. Inst. Oswaldo Cruz

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“…The pathogenesis of thrombocytopenia in liver diseases is not well established. It has been considered that splenic congestion as a consequence of portal hypertension is the major etiological factor [4,6,10]. Other than splenic congestion, increased destruction of platelets, decreased platelet production, antiplatelet antibodies, disseminated intravascular coagulation, translocated toxins or other gut-derived substances, and portosystemic shunting may play a role in the thrombocytopenia of liver disease [11][12][13][14][15][16][17][18].…”

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confidence: 99%

Liver Fibrosis Is Associated with Decreased Peripheral Platelet Count in Patients with Chronic Hepatitis B and C

et al. 2007

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Thrombocytopenia is a common complication of chronic liver diseases, but its pathogenesis is not clear. Although generally attributed to hypersplenism, other factors should also be considered. We investigated the relationship between the peripheral platelet count and the degree of fibrosis in patients with chronic viral hepatitis. In an effort to avoid the effects of hypersplenism, we excluded patients with splenomegaly and/or bi- or pan-cytopenia. Seven hundred eighty-four patients (265 chronic viral hepatitis C and 519 chronic viral hepatitis B) were included in the study. Univariate analysis showed that the peripheral platelet count had a negative correlation with fibrosis score, necroinflammatory activity, and age in both groups. In multivariate analysis, the peripheral platelet count had a similar correlation with the fibrosis score and age, but not with necroinflammatory activity, in both groups. The peripheral platelet count decreased more significantly in females with chronic hepatitis C but not in the chronic hepatitis B group. In conclusion, a decrease in peripheral platelet count may be a sign of an increase in the degree of fibrosis during the course of chronic viral hepatitis B and C and factors other than hypersplenism may play a role in this decrease in the peripheral platelet count.

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The Pathogenesis of Splenomegaly in Hypertension of the Portal Circulation; “Congestive Splenomegaly”

Cited by 46 publications

References 0 publications

Relevance of the mTOR signaling pathway in the pathophysiology of splenomegaly in rats with chronic portal hypertension

Relevance of the mTOR signaling pathway in the pathophysiology of splenomegaly in rats with chronic portal hypertension

Pathology of the spleen in hepatosplenic schistosomiasis. Morphometric evaluation and extracellular matrix changes

Liver Fibrosis Is Associated with Decreased Peripheral Platelet Count in Patients with Chronic Hepatitis B and C

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