The Pathogenesis of Rift Valley Fever

Ikegami, Tetsuro; Makino, Shinji

doi:10.3390/v3050493

Cited by 309 publications

(341 citation statements)

References 130 publications

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“…In < 2 % of symptomatic cases, the illness progresses to hemorrhagic fever, meningoencephalitis, and/or necrotizing retinitis leading to blindness [37]. While the overall mortality rate for severe RFVF infections is < 1 %, it may approach 50 % in hemorrhagic cases.…”

Section: Bunyaviridaementioning

confidence: 99%

“…Outbreaks in endemic areas have occurred with up to 20,000 cases and > 500 deaths [36]. RVFV is spread via mosquitoes or through extensive contact with blood, milk, and body tissues from infected livestock [37]. TOSV is transmitted by sandflies and causes 100 to 200 cases of meningoencephalitis each summer in Europe and North Africa [38].…”

Section: Epidemiology Of Encephalitic Arbovirusesmentioning

confidence: 99%

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Encephalitic Arboviruses: Emergence, Clinical Presentation, and Neuropathogenesis

2016

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Arboviruses are arthropod-borne viruses that exhibit worldwide distribution, contributing to systemic and neurologic infections in a variety of geographical locations. Arboviruses are transmitted to vertebral hosts during blood feedings by mosquitoes, ticks, biting flies, mites, and nits. While the majority of arboviral infections do not lead to neuroinvasive forms of disease, they are among the most severe infectious risks to the health of the human central nervous system. The neurologic diseases caused by arboviruses include meningitis, encephalitis, myelitis, encephalomyelitis, neuritis, and myositis in which virus-and immune-mediated injury may lead to severe, persisting neurologic deficits or death. Here we will review the major families of emerging arboviruses that cause neurologic infections, their neuropathogenesis and host neuroimmunologic responses, and current strategies for treatment and prevention of neurologic infections they cause.

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Section: Bunyaviridaementioning

confidence: 99%

Section: Epidemiology Of Encephalitic Arbovirusesmentioning

confidence: 99%

Encephalitic Arboviruses: Emergence, Clinical Presentation, and Neuropathogenesis

2016

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“…A high fatality rate has been reported for sheep, goats, cattle, and wildlife infected with Rift Valley fever virus (RVFV) (7,8), and infections have also led to abortion in 100% of pregnant livestock. Whether the SFTSV-or HLVlike virus detected in this study is pathogenic to animals and can cause disease if transmitted to humans remains to be determined.…”

Section: Resultsmentioning

confidence: 99%

Novel Bunyavirus in Domestic and Captive Farmed Animals, Minnesota, USA

Xing¹,

Schefers²,

Schwabenlander³

et al. 2013

Emerg. Infect. Dis.

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“…Susceptibility to infection is mostly age and species-related. Young animals are more susceptible to infection when compared to adults [23]. …”

Section: Introductionmentioning

confidence: 99%

High seroprevalence of Rift Valley fever phlebovirus in domestic ruminants and African Buffaloes in Mozambique shows need for intensified surveillance

Moiane

Mapaco

Thompson

et al. 2017

Infection Ecology & Epidemiology

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Introduction: Rift Valley fever (RVF) is an arthropod-borne disease that affects both animals and humans. RVF phlebovirus (RVFPV) is widespread in Africa and Arabian Peninsula. In Mozambique, outbreaks were reported in South; seroprevalence studies performed in livestock and water buffaloes were limited to central and south regions. We evaluated the seroprevalence of RVFPV among domestic ruminants and African buffaloes from 7 of 10 provinces of Mozambique, to understand the distribution of RVFPV and provide data for further RVF control programs. Materials and methods: A total of 1581 blood samples were collected in cattle, 1117 in goats, 85 in sheep and 69 in African buffaloes, between 2013 and 2014, and the obtained sera were analyzed by ELISA. Results and discussion: The overall seroprevalence of RVFPV domestic ruminants and African buffaloes was 25.6%. The highest was observed in cattle (37.3%) and African buffaloes (30.4%), which were higher than in previous studies within Mozambique. In south and central regions, the overall seroprevalences were higher (14.9%–62.4%) than in the north. Conclusion: This study showed the presence of anti-RVFPV antibodies in animals from all sampled provinces, suggesting that RVFPV is actively circulating among domestic ruminants and African buffaloes in Mozambique, therefore surveillance should be intensified.

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The Pathogenesis of Rift Valley Fever

Cited by 309 publications

References 130 publications

Encephalitic Arboviruses: Emergence, Clinical Presentation, and Neuropathogenesis

Encephalitic Arboviruses: Emergence, Clinical Presentation, and Neuropathogenesis

Novel Bunyavirus in Domestic and Captive Farmed Animals, Minnesota, USA

High seroprevalence of Rift Valley fever phlebovirus in domestic ruminants and African Buffaloes in Mozambique shows need for intensified surveillance

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