1985
DOI: 10.1177/030098588502200506
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The Pathogenesis of Persistent Turbinate Atrophy Induced by Toxigenic Pasteurella multocida in Pigs

Abstract: Six one-week-old piglets were pretreated with a 1% acetic acid solution for two days in one or both nostrils. Three piglets were not treated with acetic acid. Three days after treatment all nine piglets were inoculated in both nostrils with a toxigenic type D strain of Pasteurella multocida. Three piglets were killed seven days after inoculation; one died spontaneously 13 days after inoculation and the remaining pigs were killed at approximately 90 kg body weight, i.e., five to six months of age. All acetic ac… Show more

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Cited by 38 publications
(20 citation statements)
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“…The severity of the induced lesions, namely total disappearance of cartilage and woven bone as well as the disappearance of most lamellar bone within 10 days postinoculation may explain the irreversibility of atrophy observed by Elling and Pedersen (1985) and Pedersen et al, (1988). The fact that these authors used P. multocida cultures, inoculated by intranasal instillation, does not prevent this explanation, since it has been shown that broth cultures, crude DNT and purified DNT, instillated intranasally, induce the same conchae bone loss as purified DNT injected intramuscularly (Kamp and Kimman, 1988).…”
Section: Lamellar Bonementioning
confidence: 97%
See 1 more Smart Citation
“…The severity of the induced lesions, namely total disappearance of cartilage and woven bone as well as the disappearance of most lamellar bone within 10 days postinoculation may explain the irreversibility of atrophy observed by Elling and Pedersen (1985) and Pedersen et al, (1988). The fact that these authors used P. multocida cultures, inoculated by intranasal instillation, does not prevent this explanation, since it has been shown that broth cultures, crude DNT and purified DNT, instillated intranasally, induce the same conchae bone loss as purified DNT injected intramuscularly (Kamp and Kimman, 1988).…”
Section: Lamellar Bonementioning
confidence: 97%
“…bronchiseptica induces moderate and transient atrophic rhinitis, while toxigenic P. multocida is responsible for progressive severe and irreversible lesions (Elling and Pedersen, 1985;Pedersen et al, 1988). The reason for this irreversibility of the conchae lesions is unknown.…”
mentioning
confidence: 99%
“…It is now well recognized that B. bronchiseptica alone causes a mild, transient form of atrophic rhinitis [9][10][11][12][13], and while widespread, it has little impact on the productivity and health status of the animal. On the other hand, infection with toxinogenic capsular serotype D and some serotype A strains of P. multocida is associated with moderate to severe progressive atrophic rhinitis in swine (see Figure 17.1), which is accompanied by growth retardation and can have a significant health and economic impact [9,14,15]. Furthermore, it has been found that prior exposure to or coinfection with B. bronchiseptica predisposes piglets to colonization by P. multocida and to enhanced severity and progression of atrophic rhinitis and growth retardation [16][17][18][19][20][21][22][23][24].…”
Section: Atrophic Rhinitis In Swinementioning
confidence: 99%
“…Early descriptions of assays used to monitor the activity of the toxin preparations included induction of turbinate atrophy after intranasal exposure in piglets [14,20,[31][32][33][34][35][36][37]; induction of atrophic rhinitis and other organ lesions after intramuscular, intraperitoneal, or intravenous injection [31,[36][37][38][39][40][41]; induction of atrophic rhinitis and pneumonia in rabbits [34,42]; guinea pig or rat dermonecrotic lesion assays [34,[43][44][45]; BALB/c mouse lethality assay [18,34,44,46]; and cell culture assays of cytopathicity [42,[47][48][49]. Results from these studies demonstrated that purified Pasteurella multocida toxin (PMT) alone could induce turbinate atrophy and other symptoms of disease, as well as lethality, dermonecrotic, cytopathic, mitogenic, and other biological effects.…”
Section: Role Of Pmt In Pathogenesismentioning
confidence: 99%
“…Inoculation of toxigenic strains of Pasteurella multocida in the nasal cavity of young piglets pretreated with a mild acetic acid solution allows the bacteria to establish themselves, grow in the nasal cavity and induce turbinate atrophy (Pedersen & Elling, 1984;Elling & Pedersen, 1985). Toxigenic strains of P. multocida produce a protein, Pasteurella multocida toxin (PMT) which has been purified and characterized (Nakai & Kume, 1984;Foged et al, 1987).…”
Section: Introductionmentioning
confidence: 99%