The Pathogenesis of Necrobiosis Lipoidica

Engel, Margaret

doi:10.1001/archderm.1960.01580050133020

Cited by 13 publications

(1 citation statement)

References 20 publications

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“…The thickening of the vessels' walls, fibrosis, and endothelial growth resulting in occlusion in the deeper dermis are the most frequent vascular abnormalities seen in NL lesions. The connection with DM has strengthened the hypothesis that microangiopathy results from glycoprotein accumulation in the blood vessels' walls [78]. An immunohistochemical study reveals the upregulation of Glut-1 receptors in fibroblasts, suggesting a potential association with reduced blood flow.…”

Section: Vascular Impairmentmentioning

confidence: 80%

The Intersection of Dermatological Dilemmas and Endocrinological Complexities: Understanding Necrobiosis Lipoidica—A Comprehensive Review

Ionescu,

Petca,

Dumitrașcu

et al. 2024

Biomedicines

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Background: Necrobiosis lipoidica (NL) is a rare granulomatous skin disorder with a predilection for females, often associated with diabetes mellitus (DM). This paper aims to comprehensively review the literature on NL, focusing on its association with DM, thyroid disorders, and the metabolic syndrome. Methods: A systematic search was conducted in English-language literature from inception to October 2023, utilizing PubMed. We identified 530 studies and selected 19 based on clinical significance, statistical support, and relevance to the paper’s goals. Results: The coexistence of NL and DM is prevalent, with rates ranging from 11% to 65.71%. NL may precede DM diagnosis and a correlation between NL and increased daily insulin requirements has been observed in such patients. NL is suggested as a potential prognostic marker for DM complications; however, recent studies question this association, highlighting the need for further research. Studies in the context of NL and Thyroid Disease indicate a correlation, especially with autoimmune thyroiditis. Regarding NL and Metabolic Syndrome, the prevalence of metabolic syndrome among NL patients is notably higher than in the general population. Additionally, DM patients with ulcerated NL commonly exhibit hypertension or obesity, raising questions about the potential influence of hypertension and obesity on NL ulcerations. Conclusion: Additional research is required to untangle the complex connections between NL and various comorbidities.

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Section: Vascular Impairmentmentioning

confidence: 80%

The Intersection of Dermatological Dilemmas and Endocrinological Complexities: Understanding Necrobiosis Lipoidica—A Comprehensive Review

Ionescu,

Petca,

Dumitrașcu

et al. 2024

Biomedicines

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Necrobiosis Lipoidica in a Negro

Lunas¹,

Smith²

1962

Arch Dermatol

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Immunofluorescence, Necrobiosis Lipoidica, and Blood Vessels

Dahl

1988

Arch Dermatol

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New Haven, CT 06510 References 1. Braverman MS, Braverman IM: Three-dimensional reconstructions of objects from serial sections using a microcomputer graphics system. J Invest Dermatol 1986;86:290-294. 2. Perkins WJ, Green RJ: Three-dimensional reconstruction of biological sections. J Biomed Eng 1982;4:37-43. 3. Antunez J-CM, Galey FR, Linthicum FH, et al: Computer aided and graphic reconstruction of the human endolymphatic duct and sac. Ann Otol Rhinol Laryngol 1980;89(suppl 76):23-32. 4. Lindel\l=o"\fB, Forslind B, Hedblad M-A, et al: Morphology revealed by light and scanning electron microscopy and computer aided three-dimensional reconstruction. Arch Dermatol 1988; 124:1359-1363. 5. Braverman IM, Yen A: Microcirculation in psoriatic skin. J Invest Dermatol 1974;62:493-502. 6. Braverman IM, Keh-Yen A: Three-dimensional reconstruction of endothelial cell gaps in psoriatic vessels and their morphological identity with gaps produced by the intradermal injection of histamine. J Invest Dermatol 1986;86:577-581. 7. Majno G, Shea SM, Levinthal M: Endothelial contraction induced by histamine-like mediators: An electron microscopic study.

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The Pathogenesis of Necrobiosis Lipoidica

Cited by 13 publications

References 20 publications

The Intersection of Dermatological Dilemmas and Endocrinological Complexities: Understanding Necrobiosis Lipoidica—A Comprehensive Review

The Intersection of Dermatological Dilemmas and Endocrinological Complexities: Understanding Necrobiosis Lipoidica—A Comprehensive Review

Necrobiosis Lipoidica in a Negro

Immunofluorescence, Necrobiosis Lipoidica, and Blood Vessels

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