2007
DOI: 10.1016/j.ctrv.2007.07.021
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The pathogenesis of myelodysplastic syndromes (MDS)

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Cited by 10 publications
(11 citation statements)
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“…It had been reported that in early MDS increased apoptosis is partially due to up regulation of TNF-α and death receptors [36]. Here we show that the levels of TNF-α and its downstream effector cleaved caspase 8 are markedly increased on day 14.…”
Section: Resultssupporting
confidence: 57%
See 1 more Smart Citation
“…It had been reported that in early MDS increased apoptosis is partially due to up regulation of TNF-α and death receptors [36]. Here we show that the levels of TNF-α and its downstream effector cleaved caspase 8 are markedly increased on day 14.…”
Section: Resultssupporting
confidence: 57%
“…Many blue siderotic granules were surrounding the nucleus, as evidence of dyserythropoiesis found in MDS guinea pigs [33] . It has been reported that pathologic iron accumulation occurs in the erythroblasts as evidence of dyserythropoiesis in MDS [35] , [36] . Figure 2AXIV depicts blue spots (Perls' stain) in the bone marrow of MDS guinea pigs that represent iron accumulation as evidence of dyserythropoiesis.…”
Section: Resultsmentioning
confidence: 99%
“…The precise characteristics of MDS stem cells, however, have not been fully defined, and uncertainty exists over whether MDS stem-cell clones might occasionally transgress the myeloid spectrum and give rise to cells with lymphoid or bone-marrow stromal characteristics. [8][9][10] laboratory studies that have demonstrated increased apoptosis of B cells and reports of clonal lympho cytes in a subset of patients with MDS suggest that lymphoid cells might occasionally be involved in, or affected during, the pathogenesis of the disorder. 11,12 Several points are important with respect to an evaluation of the concomitant occurrence of MDS and Ivl.…”
Section: Discussion Of Diagnosismentioning
confidence: 96%
“…These are common hematological diseases in the elderly but are rarely observed in children [25]. The etiology and molecular pathogenesis of MDS are still poorly understood [26]. Both gene mutations and cytogenetic changes play important roles in the pathogenesis of this disease.…”
Section: Discussionmentioning
confidence: 99%