The Pathogenesis of Implant‐Related Reactive Lesions: A Clinical, Histologic and Polarized Light Microscopy Study

Abstract

In cases of implant failure, implantation of foreign bodies may play a role with subsequent development of I-PG and I-PGCG-like lesions. Clinicians should be aware of this risk so they can implement measures to minimize adverse implant outcomes.

Peri-implant peripheral giant cell lesions: report of 13 new cases and comparative histological and immunohistochemical analysis with peripheral and central giant cell lesions

“…The present series is the largest reported up to now and possibly includes a representative comparative profile of this condition. The previously published cases reinforce the present results showing that peri-implant PGCL is more common in the posterior mandible of females in the fifth to sixth decades of life (11-25). This distribution could be explained by the fact that dental implants are more commonly installed in the mandible of older females.…”

“…There are less than 30 cases of peri-implant PGCL reported in the English-language literature since its first description by Hirshberg et al . in 2003 (11-25). Apart from isolated case reports, only one previous comparative study has included 9 cases of peri-implant PGCL (25).…”

“…in 2003 (11-25). Apart from isolated case reports, only one previous comparative study has included 9 cases of peri-implant PGCL (25). The present series is the largest reported up to now and possibly includes a representative comparative profile of this condition.…”

Detection of Microparticles of Different Origins in Implant Prostheses and Abutments

“…ecent studies suggest that various oral pathologies may be associated with the presence of metallic and other alloplastic particles in the tissues surrounding dental implants. [1][2][3] Such reported correlations demand robust in vivo assessment, given the consideration that friction at the implant-abutment-prosthesis interfaces, implant insertion, and some therapeutic procedures may lead to biotribocorrosion and particle detachment from implant surfaces. [1][2][3][4] However, some of these microparticles may also originate from a source related to the manufacturing process, since several metal microparticles and other types of particles (eg, ceramics, polishers, resins, plaster) may be present during the fabrication of the prostheses due to incorrect decontamination.…”

“…[1][2][3] Such reported correlations demand robust in vivo assessment, given the consideration that friction at the implant-abutment-prosthesis interfaces, implant insertion, and some therapeutic procedures may lead to biotribocorrosion and particle detachment from implant surfaces. [1][2][3][4] However, some of these microparticles may also originate from a source related to the manufacturing process, since several metal microparticles and other types of particles (eg, ceramics, polishers, resins, plaster) may be present during the fabrication of the prostheses due to incorrect decontamination. Consequently, it is appropriate to hypothesize that surface debris and debris in screw-access holes could be released in the oral environment or transported by fluids (ie, microleakage) through connection gaps to the tissues surrounding dental implants.…”