The pathogenesis of experimental infections of Cryptosporidium muris (strain RN 66) in outbred nude mice

Natural Infection of Cryptosporidium muris (Apicomplexa: Cryptosporiidae) in Siberian Chipmunks

“…It is possible that observed variability in the prepatent and patent period depends both on the strain of Cryptosporidium and the experimental animal used. Results of histologic examination as well as the absence of clinical signs in chipmunks and experimentally infected mice correspond with previous reports (Iseki et al, 1989;Aydin and Ö zkul, 1996;Taylor et al, 1999). The SSU rRNA sequence was identical with C. muris sequences AF093498 and AF248761.…”

Cryptosporidium muris-like Infection in Stomach of Cynomolgus Monkeys (Macaca fascicularis)

“…The fundus glands of nude mice that were experimentally infected with C. muris were dilated and had mild epithelial changes. 13 An inflammatory reaction in experimentally infected mice was present only in animals that received the largest inoculum of 1,000,000 oocysts. In our monkeys, the epithelial changes were less severe than in the experimentally infected mice.…”

Cryptosporidium muris: Infectivity and Illness in Healthy Adult Volunteers

“…This finding is consistent with animal studies, which have noted asymptomatic infections lasting for months. 12 Of note, few infected volunteers developed diarrhea, and when it occurred, the illness did not differ from diarrhea caused by C. parvum, C. hominis, or C. meleagridis. If these results are reflective of the general population, then asymptomatic C. muris infection may be more common than is recognized.…”

“…12 It is unclear why the shedding period in volunteers was longer with C. muris compared with other Cryptosporidium species, and it may be influenced by environmental-, host-, or parasitespecific factors or some combination thereof. Indeed, wholegenome sequencing has revealed significant differences between C. muris and intestinal species.…”

“…[4][5][6][7][8][9][10] C. muris infects the gastric rather than the intestinal mucosa. 11,12 This anatomical location has been described in a number of mammalian species, 13 including immunosuppressed cynomolgus monkeys. 14 However, this has not been confirmed in humans.…”