The pathogenesis of decreased GOT and GPT activity in the plasma of hemodialysis patients: The role of vitamin B6 deficiency.

Ono, Keiji; Ono, Takashi; Hisasue, Yohko; Murakami, Takashi

doi:10.4009/jsdt.27.1319

Cited by 41 publications

(55 citation statements)

References 11 publications

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“…Although in other causes of liver injury serum ALT activity is higher than AST, in ALD, AST activity reaches higher values because of pyridoxine deficiency. Pyridoxal phosphate is a cofactor of these enzymes, with greater utilization by ALT than by AST, which leads to the increase in the AST/ALT ratio [33,34]. Our results are in agreement with these findings and they indicate that apart from MCV, the AST/ALT ratio should be incorporated into the scoring system used for the differential diagnosis of steatosis/steatohepatitis.…”

Section: Discussionsupporting

confidence: 94%

Alcoholic liver disease/nonalcoholic fatty liver disease index

Cerović

Mladenović²,

Jesic

et al. 2013

European Journal of Gastroenterology & Hepatology

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Section: Discussionsupporting

confidence: 94%

Alcoholic liver disease/nonalcoholic fatty liver disease index

Cerović

Mladenović²,

Jesic

et al. 2013

European Journal of Gastroenterology & Hepatology

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“…These findings reveal that DHA-S causes little damage to the liver. It was reported that decreased plasma ASAT and ALAT levels were caused by a deficiency of vitamin B 6 or progression of chronic renal failure (Ono et al, 1995;Fabrizi et al, 2001). In terms of pathology and blood chemistry, no evidence of renal toxicity was obtained.…”

Section: Discussionmentioning

confidence: 97%

Anticoagulant effect of sodium dehydroacetate (DHA‐S) in rats

Sakaguchi¹,

Suga²,

Oshida³

et al. 2007

J of Applied Toxicology

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Sodium dehydroacetate (DHA-S) is used as a food additive, preservative and antimicrobial agent. Repeated oral administration of DHA-S in rats induced severe hemorrhage in multiple organs and prolongation of blood coagulation factors. To determine the mechanism of hemorrhage, the protective effect of vitamin K (VK) was investigated. Increased VK-dependent blood coagulation parameters, a prolonged prothrombin time (PT) and an activated partial thromboplastin time (APTT) were observed in rats when DHA-S alone was administered, while only a slight change was observed in animals that received a single injection of vitamin K2 following the DHA-S dosing. These results suggest that DHA-S-induced hemorrhage is caused by a deficiency of vitamin K. In addition, the inhibitory effect of DHA-S on vitamin K1 epoxide reductase (VKOR) activity was measured with an in vitro system using liver microsomes of normal male rats. DHA-S concentration-dependently inhibited VKOR activity similar to warfarin, but the inhibitory concentration was high. Therefore, it was concluded that the DHA-S-induced hemorrhage was caused by a depletion of blood VK, associated with any factors including VKOR inhibition.

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“…Low alanine aminotransferase levels may indicate a liver disease such as decreased liver function or malnutrition. In particular, since the active form of vitamin B (pyridoxal-5'-phosphate) serves as a coenzyme for transaminases, low alanine aminotransferase activity may be due to malnutrition-induced occult vitamin B6 deficiency (13). In addition, the vitamin B6 status of RA patients appears to associate with disease activity (14,15).…”

Section: Discussionmentioning

confidence: 99%

Clinical Characteristics of Patients with Rheumatoid Arthritis Who have Sustained High Erythrocyte Sedimentation Rates after Clinical Remission

et al. 2014

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J o u r n a l o f R h e u m a t i c D i s e a s e s V o l . 2 1 , N o . 1 , F e b r u a r y , 2 0 1Objective. The aim of this study is to determine the clinical characteristics of patients with rheumatoid arthritis (RA) sustaining high erythrocyte sedimentation rate (ESR) despite clinical remission. Methods. This cross-sectional study involved 91 patients, who visited a tertiary medical center. Patients underwent laboratory tests and a physical examination by a rheumatologist. The disease activity score (DAS) was calculated and patients who were in remission (defined as DAS28-CRP ＜2.6) were selected. Patients were divided into two groups: those with high and low ESRs (≥40 and ＜40 mm/hr, respectively). Results. DAS 28-CRP scores revealed that 61 of the 91 patients were in remission. Of these 61 patients, 15 and 46 were allocated to the high and low ESR groups, respectively. Compared to the low ESR group, the high ESR group had a longer disease duration (99.2±60.2 vs. 59.1±48.9 months), significantly higher white blood cell counts, and CRP levels, total modified Sharp radiographic joint scores, and erosion scores, as well as significantly lower hemoglobin, albumin and alanine aminotransferase levels. Conclusion. Patients who have high ESRs despite their remission status may show progressive radiographic change. In such patients, additional treatments that decreases the inflammation and prevents radiological progression should be considered.

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The pathogenesis of decreased GOT and GPT activity in the plasma of hemodialysis patients: The role of vitamin B6 deficiency.

Cited by 41 publications

References 11 publications

Alcoholic liver disease/nonalcoholic fatty liver disease index

Alcoholic liver disease/nonalcoholic fatty liver disease index

Anticoagulant effect of sodium dehydroacetate (DHA‐S) in rats

Clinical Characteristics of Patients with Rheumatoid Arthritis Who have Sustained High Erythrocyte Sedimentation Rates after Clinical Remission

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