The pathogenesis of craniopharyngiomas

Prabhu, Vikram C.; Brown, Herbert R.

doi:10.1007/s00381-005-1190-9

Cited by 136 publications

(66 citation statements)

References 20 publications

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“…2 The tumor exhibits solid and cystic components and is thought to originate from rests of cells arising from the lumen of the craniopharyngeal duct, the precursor of the adenohypophysis. 3 Of particular interest to ophthalmologist is the locally aggressive behavior of craniopharyngiomas, causing compression of visual structures, in addition to pituitary and hypothalamic dysfunction and hydrocephalus in as many as 58% of pediatric cases.…”

Section: Introductionmentioning

confidence: 99%

Visual Outcomes after Endoscopic Endonasal Approach for Craniopharyngioma: The Pittsburgh Experience

et al. 2016

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This series of patients has been published in the neurosurgical literature earlier this year, detailing multiple aspects of both the surgical technique and postoperative outcomes. Our aim in this series is not to revisit all the aspects of this publication, but rather to analyze more specifically the benefits of this procedure as it pertains to the preservation of neurological structures of vision?specifically the optic chiasm?and provide a more detailed analysis of visual outcomes in these patients.

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Section: Introductionmentioning

confidence: 99%

Visual Outcomes after Endoscopic Endonasal Approach for Craniopharyngioma: The Pittsburgh Experience

et al. 2016

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“…6,15,18,19,23 Normally, the pituitary gland is formed by fusion of the ectoderm of the oral cavity stomodeum with the neuroectoderm of the diencephalon during the 3rd and 4th weeks of gestation. This fusion of the stomode- um and neuroectoderm gives rise to the adenohypophysis and neurohypophysis, respectively.…”

Section: Discussionmentioning

confidence: 99%

Frontal dermoid cyst coexisting with suprasellar craniopharyngioma: a spectrum of ectodermally derived epithelial-lined cystic lesions?

Abou‐Al‐Shaar

Abd-El-Barr²,

Zaidi³

et al. 2016

FOC

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There is a wide group of lesions that may exist in the sellar and suprasellar regions. Embryologically, there is varying evidence that many of these entities may in fact represent a continuum of pathology deriving from a common ectodermal origin. The authors report a case of a concomitant suprasellar craniopharyngioma invading the third ventricle with a concurrent frontal lobe cystic dermoid tumor. A 21-year-old man presented to the authors' service with a 3-day history of worsening headache, nausea, vomiting, and blurry vision. Magnetic resonance imaging depicted a right frontal lobe lesion associated with a separate suprasellar cystic lesion invading the third ventricle. The patient underwent a right pterional craniotomy for resection of both lesions. Gross-total resection of the right frontal lesion was achieved, and subtotal resection of the suprasellar lesion was accomplished with some residual tumor adherent to the walls of the third ventricle. Histopathological examination of the resected right frontal lesion documented a diagnosis of dermoid cyst and, for the suprasellar lesion, a diagnosis of adamantinomatous craniopharyngioma. The occurrence of craniopharyngioma with dermoid cyst has not been reported in the literature before. Such an association might indeed suggest the previously reported hypothesis that these lesions represent a spectrum of ectodermally derived epithelial-lined cystic lesions.

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“…It has been reported that craniopharyngioma accounts for 1.2-4% of all primary intracranial tumors and 5-10% of primary brain tumors in children [1]. It originates from the third ventricle-hypothalamus -funnel-pituitary axis [2]. Based on its histological origin, craniopharyngioma often occurs in the sella region while its clinical symptoms are usually manifested as visual disturbances and endocrine disorders [3].…”

Section: Introductionmentioning

confidence: 99%

Comparative analysis on microsurgical removal of craniopharyngioma via lateral supraorbital approach and standard pterional approach

Zhao

Chen

et al. 2018

Chin Neurosurg Jl

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Background: Craniopharyngioma is a kind of intracranial benign tumor that is primarily treated with surgery. At present, a variety of surgical approaches are used for tumor resection. We have conducted a comparative analysis of the two approaches most used in our department. Methods: The study retrospectively analyzed the clinical data from 65 patients with craniopharyngioma surgically treated by the two approaches mentioned above. Among these patients, 24 were treated by lateral supraorbital (LSO) approach and 41 by standard pterional approach. Indicators including, but not limited to, length of incision, operation time, postoperative pituitary function, urine volume, visual function improvement, and hospitalization were used to compare these two groups of patients. Results: The data shows that there was no significant difference in total tumor resection rate (P = 0.54), postoperative visual field improvement (P = 0.68) and postoperative function of endocrine. However, the LSO approach significantly reduced the operative incision (P = 0.001), shortened the operation time (P = 0.001) and operative complexity, while reducing the incidence of postoperative complications (P = 0.04). Conclusions: In surgical treatment of craniopharyngioma, LSO approach has similar surgical effect with standard pterional approach, but it can significantly shorten the operation time, reduce surgical trauma and the incidence of complications. Therefore, LSO provides another alternative to surgical approach for microsurgical removal of craniopharyngioma.

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The pathogenesis of craniopharyngiomas

Abstract: Craniopharyngiomas are benign, epithelial neoplasms of the sella and parasellar region seen in children and adults that may arise from neoplastic transformation of ectoderm-derived epithelial cell remnants of Rathke's pouch and the craniopharyngeal duct.

Cited by 136 publications

References 20 publications

Visual Outcomes after Endoscopic Endonasal Approach for Craniopharyngioma: The Pittsburgh Experience

Visual Outcomes after Endoscopic Endonasal Approach for Craniopharyngioma: The Pittsburgh Experience

Frontal dermoid cyst coexisting with suprasellar craniopharyngioma: a spectrum of ectodermally derived epithelial-lined cystic lesions?

Comparative analysis on microsurgical removal of craniopharyngioma via lateral supraorbital approach and standard pterional approach

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