The Pathogenesis of Bronchiectasis

Case 31-1998

“…These changes are characteristic of bronchiectasis, 48 which has been recognized as a complication of aspirated objects for 50 years. [49][50][51][52] In this case, the site of the foreign body within the bronchus had a cushion of granulation tissue and an ulcerated surface, with exudation of fibrin and neutrophils (Fig. 7).…”

The Origin of Lung Cysts in Childhood

“…The argument does not bear critical examination, for even in acquired bronchiectasis there is disagreement among authorities on the amount of chronic inflammatory tissue and bronchial destruction which is to be found. Lander and Davidson (1938) consider it is very slight, and Mallory (1947) and Robinson (1933) have recorded that in some cases it is quite minimal. Inflammatory changes usually subside when cellular and humoral resistance overcome the pathogenicity of the infective process.…”

Basophils

“…Bronchial dilation secondary to deficiency or loss of elastin and/or destruction of muscle and cartilage may be secondary to intrinsic or extrinsic airway (e.g., neighboring lung tissue) mechanisms in isolation or in combination (Mallory 1947;Reid 1950;Currie et al 1987;Loukides et al 2002;Chan et al 2009;Pasteur et al 2010). Although investigation of the causative factors in patients with bronchiectasis may be unrevealing, the recognition of the specific cause may have prognostic and treatment implications (Pasteur et al 2010).…”