“…Recently increasing evidences show that neuroimaging or neuroinflammatory markers are closely related with the pathological neurodegeneration in PD ( Lian et al, 2020 ; Yang et al, 2020 ; Anandhan et al, 2021 ; Li et al, 2021 ; Liu et al, 2021 ; Que et al, 2021 ; Wang et al, 2021 ; Zhu et al, 2021b ). These humoral inflammatory or imaging biomarkers may provide valuable information for early identification, differential diagnosis, assessment of severity and even prognosis prediction for PD patients ( Avenali et al, 2020 ; Beheshti et al, 2020 ).…”