The pathobiology of schistosoma haematobium infection in humans

Smith, Jerome H.; Christie, John D.

doi:10.1016/s0046-8177(86)80456-7

Cited by 112 publications

(91 citation statements)

References 39 publications

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“…Over time, morbidity may progress from subtle manifestations such as anemia, to more severe, debilitating, and irreversible conditions such as growth stunting, impaired cognitive development, increased susceptibility to co-infection, decreased quality of life, exercise intolerance, infertility, portal hypertension, and liver failure. [9][10][11][12][13][14][15] The key determinants of morbidity progression are repeated infection, intensity of infection, and duration of infection. 16 Currently, the WHO strategy for schistosomiasis control relies on mass-drug administration (MDA) of praziquantel, 17 which is effective in reducing disease-associated morbidity.…”

Section: Introductionmentioning

confidence: 99%

Schistosoma mansoni Morbidity among School-Aged Children: A SCORE Project in Kenya

Samuels

Matey²,

Mwinzi³

et al. 2012

The American Society of Tropical Medicine and Hygiene

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Abstract. Schistosomiasis control programs aim to reduce morbidity but are evaluated by infection prevalence and intensity reduction. We present baseline cross-sectional data from a nested cohort study comparing indicators of morbidity for measuring program impact. Eight hundred twenty-two schoolchildren 7-8 years of age from Nyanza Province, Kenya, contributed stool for diagnosis of Schistosoma mansoni and soil-transmitted helminths (STH) and blood smears for malaria, and were evaluated for anemia, quality of life, exercise tolerance, anthropometry, and ultrasound abnormalities. Schistosoma mansoni, STH, and malaria infection prevalence were 69%, 25%, and 8%, respectively. Only anemia and S. mansoni infection (adjusted odds ratio [aOR] = 1.70; confidence interval [CI] = 1.03-2.80), and hepatomegaly and heavy S. mansoni infection (aOR = 2.21; CI = 1.19-4.11) were associated. Though anemia and hepatomegaly appeared most useful at baseline, additional morbidity indicators may be sensitive longitudinal measures to evaluate schistosomiasis program health impact.

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Section: Introductionmentioning

confidence: 99%

Schistosoma mansoni Morbidity among School-Aged Children: A SCORE Project in Kenya

Samuels

Matey²,

Mwinzi³

et al. 2012

The American Society of Tropical Medicine and Hygiene

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“…In S. haematobium infection, the adult schistosomes preferentially localize to the veins of the kidneys, ureters and bladder, although other organs of the pelvic area are often involved (Smith & Christie 1986, Poggensee et al 1999. Egg deposition by mature female worms induces local inflammation, with granulomas, polyps, ulcers, sandy patches, and calcification of the walls of the ureters, bladder and reproductive organs (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…1). Hydronephrosis frequently occurs, either because of acute inflammation localized in the ureteral wall, or as a late consequence of cumulative fibrotic injury to the ureters (Smith & Christie 1986). In studies of S. haematobium-related morbidity from different geographic areas, results of ultrasound studies have been generally well correlated with findings from IVP and cystoscopic examination.…”

Section: Resultsmentioning

confidence: 99%

Ultrasound monitoring of structural urinary tract disease in Schistosoma haematobium infection

King

2002

Mem. Inst. Oswaldo Cruz

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“…In endemic regions, age is a proxy for duration of parasite exposure, and it is believed that S. haematobium-related tissue damage progresses from acute granulomatous injury into a more permanent form of damage caused by cumulative fibrotic changes. 7,40 Acute injury is reversible with treatment, and so young children tend to lose their pathological findings quickly unless reinfection occurs. 34,35 Our results confirm that bladder lesions regress quickly, even in adults, whereas upper tract lesions tend to regress more slowly, if at all.…”

Section: Discussionmentioning

confidence: 99%

Case–Control Study of Posttreatment Regression of Urinary Tract Morbidity Among Adults in Schistosoma haematobium–Endemic Communities in Kwale County, Kenya

Magak

Chang-Cojulun

Kadzo

et al. 2015

The American Society of Tropical Medicine and Hygiene

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Abstract. Previous population-based studies have examined treatment impact on Schistosoma-associated urinary tract disease among children, but much less is known about longer-term treatment benefits for affected adult populations in areas where risk of recurrent infection is high. In communities in Msambweni, along the Kenya coast, we identified, using a portable ultrasound, 77 adults (aged 17-85) with moderate-to-severe obstructive uropathy or bladder disease due to Schistosoma haematobium. Treatment response was assessed by repeat ultrasound 1-2 years after praziquantel (PZQ) therapy and compared with interval changes among age-and sex-matched infected/treated control subjects who did not have urinary tract abnormalities at the time of initial examination. Of the 77 affected adults, 62 (81%) had improvement in bladder and/or kidney scores after treatment, 14 (18%) had no change, and one (1.3%) had progression of disease. Of the 77 controls, 75 (97%) remained disease free by ultrasound, while two (3%) had apparent progression with abnormal findings on follow-up examination. We conclude that PZQ therapy for S. haematobium is effective in significantly reducing urinary tract morbidity from urogenital schistosomiasis among adult age groups, and affected adults stand to benefit from inclusion in mass treatment campaigns.

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The pathobiology of schistosoma haematobium infection in humans

Cited by 112 publications

References 39 publications

Schistosoma mansoni Morbidity among School-Aged Children: A SCORE Project in Kenya

Schistosoma mansoni Morbidity among School-Aged Children: A SCORE Project in Kenya

Ultrasound monitoring of structural urinary tract disease in Schistosoma haematobium infection

Case–Control Study of Posttreatment Regression of Urinary Tract Morbidity Among Adults in Schistosoma haematobium–Endemic Communities in Kwale County, Kenya

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