The pathergy test and Behcet's syndrome in Britain.

Davies, Paul; Fordham, J N; Kirwan, John R.; Barnes, Colin; Dinning, W.J.

doi:10.1136/ard.43.1.70

Cited by 83 publications

(33 citation statements)

References 7 publications

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“…The high positive rate of PR has been described in some ethnic areas such as Turkey, Iran, and Japan (18)(19)(20), but this was not the case in other countries (21,22). Furthermore, after the introduction of a disposable needle, the prevalence and intensity of a positive PR in patients with BD have been described to decrease (23).…”

Section: Discussionmentioning

confidence: 99%

Survey and Validation of the Criteria for Behcet's Disease Recently Used in Korea: a Suggestion for Modification of the International Study Group Criteria

Chang

Kim

2003

J Korean Med Sci

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have been investigated, and the diagnostic validity for those criteria was determined. For the generation of a modified set of preliminary criteria from the International Study Group (ISG) criteria, the diagnostic values for individual feature of BD were calculated. The criteria by the Beh et' s Disease Research Committee of Japan appeared to be widely employed with the ISG criteria. However, because the ISG criteria revealed a relatively valid outcome in Korea, the application of this criteria will be needed for the universal unification until the criteria with better performance comes out. On the other hand, the modified set of preliminary criteria that consisted of the clinical items with better results seemed to improve some pitfalls of the ISG criteria. Although that criteria showed better performance than the preexisting criteria, it should be necessary to validate its effectiveness in other areas.

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Section: Discussionmentioning

confidence: 99%

Survey and Validation of the Criteria for Behcet's Disease Recently Used in Korea: a Suggestion for Modification of the International Study Group Criteria

Chang

Kim

2003

J Korean Med Sci

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“…Some investigators found that the presence of a positive reaction was not related to the clinical manifestations of the disease (8,17). However, the PR was reported to be significantly associated with vascular involvement (18).…”

Section: Discussionmentioning

confidence: 99%

“…The high positive rate of PR has been described in some ethnic areas such as Turkey (2,3), Iran (4), Japan (5), and Israel (6), but this was not the case in other countries (7,8). After the introduction of a disposable needle, the prevalence and intensity of a positive PR in BD patients has been described to decrease, when compared to nondisposable needle used in pre-AIDS era (9).…”

Section: Introductionmentioning

confidence: 99%

The Clinical Significance of a Pathergy Reaction in Patients with Behcet's Disease

Chang

Cheon

2002

J Korean Med Sci

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This study was done to evaluate the frequency, intensity, and specificity of a positive pathergy reaction (PR) in Behcet's disease (BD) patients, to clarify an association between the PR and the clinical features or disease severity, and to assess whether patients with pustule formation at the venous puncture site (PFVPS) without positive PR could be regarded as a positive reaction. The PR was tested in 64 BD patients, 74 disease controls, and 20 healthy controls. Venous PR was performed in 8 BD patients with PFVPS. Follow-up PR was done in 14 patients with positive reaction during inactive phase. The PR was positive in 35.9% of BD patients, in 1 patient among disease controls, and in none of healthy controls. The pustule formation was observed in one BD patient. There was no statistical significance between positive PR and the clinical variables. The mean clinical activity score of BD patients with positive PR was similar to patients with negative reaction. Venous PR was positive in 7 patients. The follow-up PR was positive in 2 patients during inactive phase. Conclusively the positive PR appeared to be specific for BD, and was not associated with the clinical variables or disease severity, but was usually found during active phase in cases with positive reaction. The PFVPS in patients with negative PR might be considered to be positive.

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“…The antibacterial host response by T cell type immunity mediated by IL-12 is suggested to be much stronger in HLA-B51-negative BD patients in vitro experiment. In our cases, about 33% of the patients were associated with HLA-B51 (Table 2) and the severity of the Salivary prick test might be correlated with the disease activity in BD patients, though Pathergy test was reported to be stronger than those of patients with HLA-B51 [45,49,60] .…”

Section: Pathergy Test and Oral Streptococcimentioning

confidence: 59%

“…However, recently the reactivity by Pathergy test became chronologically lower to less than 40% of BD patients seen in 2007s, though the response was seen in more than 70% of the patients in 1970s. The patients associated with HLA-B51 were thought to show stronger skin reaction by Pathergy test [43] , but its diagnostic value is different from the prevalence in the countries [44][45][46] . In our cases, only one of 22 cases showed a 2 mm pustule 48 h after pricking with 20 G syringe needle, which Pathergy reactivity was less than 5% ( Figure 3b).…”

Section: Pathergy Test and Oral Streptococcimentioning

confidence: 99%

Behcet’s Disease and Related Diseases -Immune Reactions to Oralstreptococci in Their Pathogenesis

Kaneko

Togashi

Nomura

et al. 2016

Journal of Dermatological Research

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the retinal protein Brn3b which might be connected with the eye involvement in BD patients. Also, the peptides seem to be homologous with HSP-65 in association with the human HSP-60 which reactively appeared in serum of the patients involved by S. sanguinis.Then, the pathogenesis of BD was conclusively discussed on the relationship between RAS and the systemic symptoms by the vascular reaction due to immune responses against antigens derived from S. sanguinis. Non-BD patients with RAS and/or Lipschutz genital ulceration were weekly sensitized by oral streptococci, except for patients with EN. [2][3][4] .Although the actual etiology of BD is still unclear, the pathogenesis has been generally clearer by the etiological studies based on the genetic intrinsic factors and extrinsic triggering factors [5][6][7][8][9][10][11][12][13][14][15][16] . As one of the triggering factors, the oral unhygienic condition may be suspected, because periodontitis, decayed teeth, chronic tonsillitis, etc. are frequently noted in BD patients [12,13] . The proportion of Streptococcus sanguinis (S. sanguinis), which was previously recognized as species of the genus Streptococcus named "S. sanguis", was significantly high ABSTRACTBehçet's disease (BD) is a systemic disorder characterized by the recurrent involvement in the muco-cutaneous, ocular, intestinal, vascular, and/or nervous system organs. The clinical muco-cutaneous manifestations including recurrent aphthous stomatitis (RAS), erythema nodosum (EN) -like eruption, genital ulceration, etc. of patients with BD were reviewed in their pathogenesis comparing with the similar symptoms seen in patients without BD (non-BD). Most of BD patients tend to have hypersensitivity against streptococci which might be acquired in the oral cavity through the innate immune mechanism. Generally, BD patients have the systemic symptoms following RAS symptom as an immune reaction. Then, the characteristics of hypersensitivity to oral streptococci may be utilized in order to make a diagnosis for BD. The skin prick with self-saliva including oral streptococci was much more sensitive than "Pathergy test" conventionally used for BD diagnosis. HLA-B51-restricted CD8+ T cell response is suspected to catch the target tissues expressing major histocompatibility complex class 1 chain-related gene A (MICA) by stress in active BD patients. Bes-1 gene and 65kD of heat shock protein (HSP-65) derived from Streptococcus sanguinis (S. sanguinis) are detectable in the lesions. The peptides of Bes-1 gene are highly homologous with REVIEW

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The pathergy test and Behcet's syndrome in Britain.

Cited by 83 publications

References 7 publications

Survey and Validation of the Criteria for Behcet's Disease Recently Used in Korea: a Suggestion for Modification of the International Study Group Criteria

Survey and Validation of the Criteria for Behcet's Disease Recently Used in Korea: a Suggestion for Modification of the International Study Group Criteria

The Clinical Significance of a Pathergy Reaction in Patients with Behcet's Disease

Behcet’s Disease and Related Diseases -Immune Reactions to Oralstreptococci in Their Pathogenesis

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