The path towards herd immunity: Predicting COVID-19 vaccination uptake through results from a stated choice study across six continents

Hess, Stephane; Lancsar, Emily; Mariel, Petr; Meyerhoff, Jürgen; Song, Fangqing; Broek-Altenburg, Eline van den; Alaba, Olufunke A.; Amaris, Gloria; Arellana, Julián; Basso, Leonardo J.; Benson, Jamie; Bravo-Moncayo, Luis; Chanel, Olivier; Choi, Syngjoo; Sourd, Romain Crastes dit; Cybis, Helena Bettella; Dorner, Zack; Falco, Paolo; Garzón-Pérez, Luis; Glass, Kathryn; Guzmán, Luis A.; Huang, Zhiran; Huynh, Elisabeth; Kim, Bongseop; Konstantinus, Abisai; Konstantinus, Iyaloo N.; Larrañaga, Ana Margarita; Longo, Alberto; Loo, Becky P.Y.; Moyo, Hazvinei Tamuka; Oehlmann, Malte; O’Neill, Vikki; Ortúzar, Juan de Dios; Sánchez, María José Sanz; Sarmiento, Olga L.; Tucker, Steven; Wang, Yacan; Wang, Yu; Webb, Edward; Zhang, Jun‐Yi; Zuidgeest, Mark

doi:10.1016/j.socscimed.2022.114800

Cited by 19 publications

(16 citation statements)

References 58 publications

(67 reference statements)

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“…1,2 Although the severity of infections has reduced so that COVID-19 has been announced as an "endemic" in many countries, 3 attempts toward drug and immunity booster development have been continuing to lead to the "herd immunity" of the global population. 4,5 SARS-CoV2, classified in the subgenus sarbecovirus of the genus betacoronavirus, is one of the enveloped, positive-sense, singlestranded RNA viruses. 6 A SARS-CoV2 virion, as well as other types of coronaviruses, consists of structural proteins to form spherical shells to contain the viral RNA and spike glycoproteins to attach and fuse with the target cell.…”

Section: Introductionmentioning

confidence: 99%

“…The global outbreak of COVID-19 through the infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) has caused over 600 million reported cases and over 6 million deaths around the world within 33 months (as of September 2022) and caused significant public health and economic impacts. , Although the severity of infections has reduced so that COVID-19 has been announced as an “endemic” in many countries, attempts toward drug and immunity booster development have been continuing to lead to the “herd immunity” of the global population. , SARS-CoV2, classified in the subgenus sarbecovirus of the genus betacoronavirus , is one of the enveloped, positive-sense, single-stranded RNA viruses . A SARS-CoV2 virion, as well as other types of coronaviruses, consists of structural proteins to form spherical shells to contain the viral RNA and spike glycoproteins to attach and fuse with the target cell .…”

Section: Introductionmentioning

confidence: 99%

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Biophysical Interpretation of Evolutionary Consequences on the SARS-CoV2 Main Protease through Molecular Dynamics Simulations and Network Topology Analysis

et al. 2023

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In this study, we present a combined analysis procedure between atomistic molecular dynamics (MD) simulations and network topology to obtain more understanding on the evolutionary consequences on protein stability and substrate binding of the main protease enzyme of SARS-CoV2. Communicability matrices of the protein residue networks (PRNs) were extracted from MD trajectories of both Mpro enzymes in complex with the nsp8/9 peptide substrate to compare the local communicability within both proteases that would affect the enzyme function, along with biophysical details on global protein conformation, flexibility, and contribution of amino acid side chains to both intramolecular and intermolecular interactions. The analysis displayed the significance of the mutated residue 46 with the highest communicability gain to the binding pocket closure. Interestingly, the mutated residue 134 with the highest communicability loss corresponded to a local structural disruption of the adjacent peptide loop. The enhanced flexibility of the disrupted loop connecting to the catalytic residue Cys145 introduced an extra binding mode that brought the substrate in proximity and could facilitate the reaction. This understanding might provide further help in the drug development strategy against SARS-CoV2 and prove the capability of the combined techniques of MD simulations and network topology analysis as a “reverse” protein engineering tool.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Biophysical Interpretation of Evolutionary Consequences on the SARS-CoV2 Main Protease through Molecular Dynamics Simulations and Network Topology Analysis

et al. 2023

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“…Most studies on this topic emphasize a single country such as the United States ( Szilagyi et al, 2021 ), the United Kingdom ( Becchetti et al, 2021 ), Germany ( Seddig et al, 2022 ), Italy ( Capasso et al, 2021 ), Netherlands ( Mouter et al, 2022 ), Sweden ( Campos-Mercade et al, 2021 ), Turkey ( Dal and Tokdemir, 2022 ), Japan ( Sasaki et al, 2022 ), and Singapore ( Tan et al, 2022 ). However, few studies analyze data across countries ( Barceló et al, 2022 ; Breslin et al, 2021 ; Hess et al, 2022 ; Lazarus et al, 2021 ; Murphy et al, 2021 ; Neumann-Böhme et al, 2020 ). More importantly, these cross-national studies typically use surveys before the vaccine is available and thus focus on people's willingness to take the vaccine, not gauging whether people had taken the vaccine.…”

Section: Introductionmentioning

confidence: 99%

A cross-national study of multilevel determinants on public fully vaccination against COVID-19

Feng

2023

Health & Place

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“…20 This model highlights: 1) confidence and trust barriers, 2) complacency and perception of risk barriers and 3) convenience, structural and socio-economic barriers. Conversely, greater vaccine acceptance is associated with greater trust in health authorities, 23,24 greater availability of accurate and accessible information for those considering vaccines 25,26 26 and confidence in vaccine effectiveness and length of disease protection. 27 Where we think the term 'vaccine hesitancy' can be useful is that it is not binary, people exist on a hesitancy and acceptance spectrum or continuum.…”

Section: Introductionmentioning

confidence: 99%

Compliant citizens, defiant rebels or neither? Exploring changing COVID-19 vaccine attitudes and decisions in Bradford, UK: Findings from a follow-up qualitative study

Lockyer

Moss

Endacott

et al. 2022

Preprint

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Background: COVID-19 vaccines have been the central pillar of the public health response to the pandemic, intended to enable us to "live with Covid". It is important to understand COVID-19 vaccines attitudes and decisions in order to maximise uptake through an empathetic lens. Objective: To explore the factors that influenced people's COVID-19 vaccines decisions and how attitudes towards the vaccines had changed in an eventful year. Design and participants: This is a follow up study that took place in Bradford, UK one year after the original study, between October 2021 and January 2022. In-depth phone interviews were conducted with 12 (of the 20 originally interviewed) people from different ethnic groups and areas of Bradford. Reflexive thematic analysis was conducted. Results: 11 of the 12 participants interviewed had received both doses of the COVID-19 vaccine and most intended to have a booster dose. Participants described a variety of reasons why they had decided to have the vaccines, including: feeling at increased risk at work; protecting family and others in their communities, unrestricted travel and being influenced by the vaccine decisions of family, friends and colleagues. All participants discussed ongoing interaction with COVID-19 misinformation and for some this meant they were uneasy about their decision to have the vaccine. They described feeling overloaded by and disengaged from COVID-19 information, which they often found contradictory and some felt mistrustful of the UK government's motives and decisions during the pandemic. Conclusions: The majority of participants had managed to navigate an overwhelming amount of circulating COVID-19 misinformation and chosen to have two or more COVID-19 vaccines, even if they had been previously said they were unsure. However, these decisions were complicated, and demonstrate the continuum of vaccine hesitancy and acceptance. This follow up study underlines that vaccine attitudes are changeable and contextual. Patient or Public Contribution: The original study was developed through a rapid community and stakeholder engagement process in 2020. Discussion with the Bradford Council Public Health team and the public through the Bradford COVID-19 Community Insights Group was undertaken in 2021 to identify important priorities for this follow up study.

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The path towards herd immunity: Predicting COVID-19 vaccination uptake through results from a stated choice study across six continents

Cited by 19 publications

References 58 publications

Biophysical Interpretation of Evolutionary Consequences on the SARS-CoV2 Main Protease through Molecular Dynamics Simulations and Network Topology Analysis

Biophysical Interpretation of Evolutionary Consequences on the SARS-CoV2 Main Protease through Molecular Dynamics Simulations and Network Topology Analysis

A cross-national study of multilevel determinants on public fully vaccination against COVID-19

Compliant citizens, defiant rebels or neither? Exploring changing COVID-19 vaccine attitudes and decisions in Bradford, UK: Findings from a follow-up qualitative study

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