The paternal hidden agenda: Epigenetic inheritance through sperm chromatin

Puri, Deepika; Dhawan, Jyotsna; Mishra, Rakesh

doi:10.4161/epi.5.5.12005

Cited by 59 publications

(41 citation statements)

References 55 publications

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“…Additionally, similar to what seems to happen in other cells (Lu & Thompson 2012), a crosstalk between mitochondrial metabolism and sperm epigenetics may exist. This is especially relevant given the recent finding that the sperm chromatin may transfer acquired epigenetic states across generations (Puri et al 2010). …”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Mitochondria functionality and sperm quality

Amaral¹,

Lourenço²,

Marques³

et al. 2013

Reproduction

412

332

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Although mitochondria are best known for being the eukaryotic cell powerhouses, these organelles participate in various cellular functions besides ATP production, such as calcium homoeostasis, generation of reactive oxygen species (ROS), the intrinsic apoptotic pathway and steroid hormone biosynthesis. The aim of this review was to discuss the putative roles of mitochondria in mammalian sperm function and how they may relate to sperm quality and fertilisation ability, particularly in humans. Although paternal mitochondria are degraded inside the zygote, sperm mitochondrial functionality seems to be critical for fertilisation. Indeed, changes in mitochondrial integrity/functionality, namely defects in mitochondrial ultrastructure or in the mitochondrial genome, transcriptome or proteome, as well as low mitochondrial membrane potential or altered oxygen consumption, have been correlated with loss of sperm function (particularly with decreased motility). Results from genetically engineered mouse models also confirmed this trend. On the other hand, increasing evidence suggests that mitochondria derived ATP is not crucial for sperm motility and that glycolysis may be the main ATP supplier for this particular aspect of sperm function. However, there are contradictory data in the literature regarding sperm bioenergetics. The relevance of sperm mitochondria may thus be associated with their role in other physiological features, particularly with the production of ROS, which in controlled levels are needed for proper sperm function. Sperm mitochondria may also serve as intracellular Ca 2C stores, although their role in signalling is still unclear.

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Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Mitochondria functionality and sperm quality

Amaral¹,

Lourenço²,

Marques³

et al. 2013

Reproduction

412

332

View full text Add to dashboard Cite

show abstract

“…Thus far only the histones and protamines have been validated to be a part of non-genomic paternal contribution to embryo [Brunner 2014;Jenkins and Carrell 2011;Kumar et al 2013;Puri et al 2010;Schagdarsurengin et al 2012;van de Werken et al 2014;van der Heijden et al 2008;Ward 2010]. However besides these, a portion of the nuclear matrix proteins and perinuclear theca proteins are also inherited by the newly fertilized embryo and can be implicated to have certain epigenetic significance [Yamauchi et al 2011].…”

Section: Introductionmentioning

confidence: 99%

Histone retention, protein carbonylation, and lipid peroxidation in spermatozoa: Possible role in recurrent pregnancy loss

Mohanty

Swain

Goswami

et al. 2016

Systems Biology in Reproductive Medicine

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Contribution from a defective paternal genome has been attributed to be an important cause for spontaneous recurrent pregnancy loss (RPL). Increased oxidative stress results in decreased detoxification and is a cause for damage to chromatin, proteins, and membrane lipids. The present study aimed to explore if there is a significant relationship between retained histones due to defective packaging of DNA in spermatozoa and oxidative stress. RPL patients (n=16) with a history of ≥2 embryo losses before the 20th week of gestation and no female factor abnormality, and fertile healthy volunteers (n=20) as controls were included in the study. A significant difference in the levels of protein carbonylation and lipid peroxidation together with an increased retention of histones in the experimental groups was noticed. Histone carrying sites for oxidative modification such as arginine and lysine might be responsible for disturbing the paternal epigenomic control during early stages of embryonic differentiation leading to abortion. ARTICLE HISTORY

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“…Структура конденси-рованного хроматина и правильная протаминизация обуславливает эпигенетическую регуляцию раннего эмбриогенеза [28]. Соответственно, нарушение прота-минизации приводит к аномалиям беременности и не-удачам ВРТ [4,23,24,74,75]. Аналогичные данные получены на мышиной модели [76].…”

Section: корреляционная электронная микроскопияunclassified