The past 12,000 years of behavior, adaptation, population, and evolution shaped who we are today

Larsen, Clark Spencer

doi:10.1073/pnas.2209613120

Cited by 7 publications

(10 citation statements)

References 24 publications

(25 reference statements)

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“…During this time, humans and HBV genotypes were subjected to selective pressures shaping their coevolutionary dynamics. Humans experienced different environmental conditions, infectious diseases, diets, and social interactions [ 101 ]. These pressures can influence human genetic diversity, metabolism, immunity, and infection susceptibility [ 101 ].…”

Section: The Theory Of Viral Adaptationmentioning

confidence: 99%

“…Humans experienced different environmental conditions, infectious diseases, diets, and social interactions [ 101 ]. These pressures can influence human genetic diversity, metabolism, immunity, and infection susceptibility [ 101 ]. Simultaneously, HBV adapted to the selective pressures imposed by the host, leading to a complex interaction (HBV/human) that could determine its current distribution, epidemiology, and clinical outcomes.…”

Section: The Theory Of Viral Adaptationmentioning

confidence: 99%

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Host and HBV Interactions and Their Potential Impact on Clinical Outcomes

Jose-Abrego,

Roman,

Laguna-Meraz

et al. 2023

Pathogens

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Hepatitis B virus (HBV) is a challenge for global health services, affecting millions and leading thousands to end-stage liver disease each year. This comprehensive review explores the interactions between HBV and the host, examining their impact on clinical outcomes. HBV infection encompasses a spectrum of severity, ranging from acute hepatitis B to chronic hepatitis B, which can potentially progress to cirrhosis and hepatocellular carcinoma (HCC). Occult hepatitis B infection (OBI), characterized by low HBV DNA levels in hepatitis B surface antigen-negative individuals, can reactivate and cause acute hepatitis B. HBV genotyping has revealed unique geographical patterns and relationships with clinical outcomes. Moreover, single nucleotide polymorphisms (SNPs) within the human host genome have been linked to several clinical outcomes, including cirrhosis, HCC, OBI, hepatitis B reactivation, and spontaneous clearance. The immune response plays a key role in controlling HBV infection by eliminating infected cells and neutralizing HBV in the bloodstream. Furthermore, HBV can modulate host metabolic pathways involved in glucose and lipid metabolism and bile acid absorption, influencing disease progression. HBV clinical outcomes correlate with three levels of viral adaptation. In conclusion, the clinical outcomes of HBV infection could result from complex immune and metabolic interactions between the host and HBV. These outcomes can vary among populations and are influenced by HBV genotypes, host genetics, environmental factors, and lifestyle. Understanding the degrees of HBV adaptation is essential for developing region-specific control and prevention measures.

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Section: The Theory Of Viral Adaptationmentioning

confidence: 99%

Section: The Theory Of Viral Adaptationmentioning

confidence: 99%

Host and HBV Interactions and Their Potential Impact on Clinical Outcomes

Jose-Abrego,

Roman,

Laguna-Meraz

et al. 2023

Pathogens

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“…These include sedentism, property ownership, social hierarchy, specialist craft production and related technological change, greater population density, and increased frequencies of infectious diseases and zoonotic diseases associated with domestic animals. Collectively, these changes have generally been seen to be associated with bioarcheological evidence for declining human stature and skeletal indicators of health ( Larsen, 2023 ).…”

Section: Agriculture and The Origins Of Dairyingmentioning

confidence: 99%

Dairying and the evolution and consequences of lactase persistence in humans

Stock

Wells

2023

Animal Frontiers

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“…The advent of aDNA has especially helped in identifying evidence for selection and associated adaptation events 27 . The human bioarchaeology of this process has received much attention, having been outlined in classic studies 28 – 30 , as well as more recent reassessments 3 , 31 – 33 . In general, the shift to a farming lifestyle is associated with a population ‘boom’ and a series of negative health impacts as communities changed their diets, became sedentary and gathered into larger settlements with poorer sanitation and closer contact with animals, leading to an increase in infectious and zoonotic diseases 34 – 36 .…”

Section: Introductionmentioning

confidence: 99%

Multiproxy bioarchaeological data reveals interplay between growth, diet and population dynamics across the transition to farming in the central Mediterranean

Parkinson,

Stoddart,

Sparacello

et al. 2023

Sci Rep

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The transition to farming brought on a series of important changes in human society, lifestyle, diet and health. The human bioarchaeology of the agricultural transition has received much attention, however, relatively few studies have directly tested the interrelationship between individual lifestyle factors and their implications for understanding life history changes among the first farmers. We investigate the interplay between skeletal growth, diet, physical activity and population size across 30,000 years in the central Mediterranean through a ‘big data’ cross-analysis of osteological data related to stature (n = 361), body mass (n = 334) and long bone biomechanics (n = 481), carbon (δ13C) and nitrogen (δ15N) stable isotopes (n = 1986 human, n = 475 animal) and radiocarbon dates (n = 5263). We present the observed trends on a continuous timescale in order to avoid grouping our data into assigned ‘time periods’, thus achieving greater resolution and chronological control over our analysis. The results identify important changes in human life history strategies associated with the first farmers, but also highlight the long-term nature of these trends in the millennia either side of the agricultural transition. The integration of these different data is an important step towards disentangling the complex relationship between demography, diet and health, and reconstruct life history changes within a southern European context. We believe the methodological approach adopted here has broader global implications for bioarchaeological studies of human adaptation more generally.

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The past 12,000 years of behavior, adaptation, population, and evolution shaped who we are today

Cited by 7 publications

References 24 publications

Host and HBV Interactions and Their Potential Impact on Clinical Outcomes

Host and HBV Interactions and Their Potential Impact on Clinical Outcomes

Dairying and the evolution and consequences of lactase persistence in humans

Multiproxy bioarchaeological data reveals interplay between growth, diet and population dynamics across the transition to farming in the central Mediterranean

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