The Particulars on Parechovirus

Shah, G. L.; Robinson, Joan

doi:10.1155/2014/602501

Cited by 14 publications

(8 citation statements)

References 48 publications

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“…Nonetheless, 2 editorials from North American journals have emphasized the necessity to diagnose HPeV infections. 61,62 A recent international consortium working group on encephalitis diagnosis has also included HPeV testing in its recommendations for cases occurring in children less than 3 years old. 63 In order to make the diagnosis rapidly, more laboratories should be able to perform HPeV RT-PCR testing in the coming years.…”

Section: Diagnosismentioning

confidence: 99%

Human Parechovirus 3

Renaud¹,

Harrison²

2015

Infectious Disease Clinics of North America

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Section: Diagnosismentioning

confidence: 99%

Human Parechovirus 3

Renaud¹,

Harrison²

2015

Infectious Disease Clinics of North America

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“…Parechovirus can cause a sepsis‐like syndrome or meningitis in neonates, with genotype 3 being the most common strain causing these clinical manifestations . We need to be familiar with the association of parechovirus infection with acral erythema and swelling as this condition is self‐limiting and needs no further intervention . We did not have the opportunity to sub‐type the strain of parechovirus.…”

Section: Discussionmentioning

confidence: 99%

Atypical acral swelling and viral exanthem with parechovirus meningitis

Chowdhury

Lee

2019

J Paediatrics Child Health

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We present a case of a febrile 3-month-old infant with atypical acral swelling and erythema for 2 days' duration. He was born full-term via normal vaginal delivery, with no maternal risk factors for sepsis. His parents sought medical attention in view of increasing lethargy and irritability. On physical examination, there was a blanching maculo-papular rash over the trunk and extremities with acral swelling (Figs 1-3). The infant was febrile (maximum temperature 39.8 C) with tachycardia that was out of proportion to fever spikes. His heart rate was in the range of 180-200 beats/min, which raised concerns for underlying sepsis. Intravenous ampicillin and gentamicin were administered immediately. His white cell count was 5.30 × 10 9 /L (5-15 × 10 9 /L; 48% neutrophils, 41% lymphocytes, 10% monocytes) and C-reactive protein level was unremarkable (6.3 mg/L). Blood, urine and cerebrospinal (CSF) cultures were negative. CSF did not reveal any pleocytosis (CSF WBC 0, CSF protein 0.26 g/L). In view of worsening acral erythema associated with swelling, there were concerns of evolving Kawasaki disease (KD).Blood tests were repeated on the third day of hospitalisation due to concerns of KD as child had persistent irritability and fever Fig. 1 Swelling over dorsum of the foot.Fig. 2 Swelling over dorsum of hand. Key Points1 Acral swelling is an uncommon presentation and should raise concerns for Kawasaki disease or parechovirus infection depending on the clinical context. 2 Parechovirus infection is self-limiting and thus prompt isolation of this virus can prevent unnecessary investigations. 3 Parechovirus infection can present with a range of symptoms from being asymptomatic to sepsis-like illness in an infant.

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“…In this study, we used HPeV as an example to investigate the genetic diversity of viral genomes. This virus is highly infectious and causes a variety of symptoms in early childhood [ 38 ] and has atypical molecular and biological properties [ 13 ]. This study is the first to report the three genetic diversities of Taiwanese HPeV strains through various analyses, as follows.…”

Section: Discussionmentioning

confidence: 99%

“…It is also an ssRNA virus with an approximately 7.3-kb genome. HPeV primarily causes sepsis and central nervous system (CNS) diseases in infants, and still has other unproven clinical manifestations [ 13 ]. Laboratory diagnosis of HPeV is not routinely available in clinical practice and is still evolving; antiviral therapy is also being developed [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

A Next-Generation Sequencing Data Analysis Pipeline for Detecting Unknown Pathogens from Mixed Clinical Samples and Revealing Their Genetic Diversity

et al. 2016

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Forty-two cytopathic effect (CPE)-positive isolates were collected from 2008 to 2012. All isolates could not be identified for known viral pathogens by routine diagnostic assays. They were pooled into 8 groups of 5–6 isolates to reduce the sequencing cost. Next-generation sequencing (NGS) was conducted for each group of mixed samples, and the proposed data analysis pipeline was used to identify viral pathogens in these mixed samples. Polymerase chain reaction (PCR) or enzyme-linked immunosorbent assay (ELISA) was individually conducted for each of these 42 isolates depending on the predicted viral types in each group. Two isolates remained unknown after these tests. Moreover, iteration mapping was implemented for each of these 2 isolates, and predicted human parechovirus (HPeV) in both. In summary, our NGS pipeline detected the following viruses among the 42 isolates: 29 human rhinoviruses (HRVs), 10 HPeVs, 1 human adenovirus (HAdV), 1 echovirus and 1 rotavirus. We then focused on the 10 identified Taiwanese HPeVs because of their reported clinical significance over HRVs. Their genomes were assembled and their genetic diversity was explored. One novel 6-bp deletion was found in one HPeV-1 virus. In terms of nucleotide heterogeneity, 64 genetic variants were detected from these HPeVs using the mapped NGS reads. Most importantly, a recombination event was found between our HPeV-3 and a known HPeV-4 strain in the database. Similar event was detected in the other HPeV-3 strains in the same clade of the phylogenetic tree. These findings demonstrated that the proposed NGS data analysis pipeline identified unknown viruses from the mixed clinical samples, revealed their genetic identity and variants, and characterized their genetic features in terms of viral evolution.

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The Particulars on Parechovirus

Cited by 14 publications

References 48 publications

Human Parechovirus 3

Human Parechovirus 3

Atypical acral swelling and viral exanthem with parechovirus meningitis

A Next-Generation Sequencing Data Analysis Pipeline for Detecting Unknown Pathogens from Mixed Clinical Samples and Revealing Their Genetic Diversity

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