The Partial Purification and Characterization of Adenosine Kinase from Entamoeba histolytica *

Lobelle‐Rich, Patricia; Reeves, Richard E.

doi:10.4269/ajtmh.1983.32.976

Cited by 14 publications

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“…These workers also suggested the presence of two nucleoside phosphorylases, one active on adenosine and the other on inosine, distinguishable by their different responses to pH and their sensitivity to inhibitors. Adenosine kinase has been purified from E. histolytica [156] and shown to have activity towards the adenosine analogue tubercidin, but not arabinosyladenine. Both compounds inhibit the growth of E. histolytica [157], although the mechanism by which these compounds exert their effect remains to be determined.…”

Section: Entamoeba Histolyticamentioning

confidence: 99%

Purine and pyrimidine metabolism in parasitic protozoa

Hassan¹

1988

FEMS Microbiology Letters

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Section: Entamoeba Histolyticamentioning

confidence: 99%

Purine and pyrimidine metabolism in parasitic protozoa

Hassan¹

1988

FEMS Microbiology Letters

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Biochemistry of Entamoeba: A review

Avron

Chayen

1988

Cell Biochemistry & Function

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Entamoeba histolytica, the protozoan parasite causing amoebiasis, is carried by approximately 10% of the world's population although only a minority of carriers of the organism present active clinical symptoms.Although Entamoeba are classified as eukaryotes, the biochemistry of these organisms has a number of unusual facets which are reminiscent of prokaryotes. It has indeed been suggested that these cells represent early evolutionary forms that have been successful in surviving unchanged in the protected environment in which they reproduce (the intestine).Glycolysis in Entarnoeba lacks several of the typical eukaryotic glycolytic enzymes. The pentose phosphate shunt enzymes are missing completely. Another unusual feature of the glycolytic path is the utilization of PP, instead of ATP in a number of enzyme reactions e.g. phosphofructokinase. Entamoeba is the only eukaryote in which one of these PP, utilizing enzymes, phosphoenolpyruvate carboxytransferase, has been found.The respiratory pathway is also an unusual one. Entamoeba are classified as anaerobes but the cells do have an affinity for oxygen. The oxygen is reduced to water at the end of a respiratory chain which is not well understood but which operates withough cytochromes or mitochondria.The nucleic acid, protein and lipid metabolic pathways have not been well studied and interest has mainly focused on the proteolytic processes of the amoeba which have been implicated in the pathogenic, histolytic behavior of the parasite. Despite these efforts the mechanism of attack of the parasite and the stimuli that cause it to invade the host are not yet clear. This understandably is the goal of much of the present studies concerning E. histolytica but the organism also deserves study in its own right as an example of an organism that has an unusual biochemistry and may represent an early stage in the evolution of eukaryotic cells.

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Adenosine kinase

Springer Handbook of Enzymes

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The Partial Purification and Characterization of Adenosine Kinase from Entamoeba histolytica *

Cited by 14 publications

References 0 publications

Purine and pyrimidine metabolism in parasitic protozoa

Purine and pyrimidine metabolism in parasitic protozoa

Biochemistry of Entamoeba: A review

Adenosine kinase

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