The partial molar volumes of some tetra- and pentapeptides in aqueous solution: a test of amino acid side-chain group additivity for unfolded proteins

Partial Molar Isentropic Compressions of Some Tetra- and Pentapeptides in Aqueous Solution: Implications for Group Additivity Schemes for Unfolded Proteins

“…The reproducibility of solution densities was used as a criterion of purity of the solid. The densities of two solutions prepared using this recovered material were identical, within the combined experimental uncertainties, with those reported previously [33]. The peptides glyglyserglygly·2.0H 2 O, glyglyseralagly and glyproalaalagly·2.0H 2 O were samples remaining from previous studies.…”

“…The synthesis, purification and characterization of each solid peptide sample have been described in a previous paper that reports the density data [33]. The synthesis and characterization of glyphealagly has also been described previously [33]. Because of the limited amount of this peptide available for the current study, two solutions were prepared using vacuum dried solid material that had been recovered from the other solutions used in this work.…”

“…The synthesis, purification and characterization of each solid peptide sample have been described in a previous paper that reports the density data [33]. The synthesis and characterization of glyphealagly has also been described previously [33].…”

“…Because of the limited amount of this peptide available for the current study, two solutions were prepared using vacuum dried solid material that had been recovered from the other solutions used in this work. The sample of glyglyleuglygly used was material that had been recovered from previous studies [33,34] and then recrystallized from (water + methanol). The reproducibility of solution densities was used as a criterion of purity of the solid.…”

Apparent and partial molar heat capacities and volumes of the amino acids l -lysine monohydrochloride andl -arginine monohydrochloride in aqueous solution at temperatures from T= 288.15 K to T= 328.15 K

“…It is worthwhile, therefore, to verify the side-chain heat capacity and volume reported previously (11,14) by using an alternative model compound, such as the amino acid arginine. Although the use of the zwitterionic amino acids as compounds to model the side-chains in proteins has limitations, (4,9) the results obtained using arginine as a model compound are nevertheless useful for the purpose of comparison.…”