The partial molar heat capacity and volume of the peptide backbone group of proteins in aqueous solution

Partial molar volumes and heat capacities of the N-acetyl amide derivatives of the amino acids asparagine, glutamine, tyrosine, and lysine monohydrochloride in aqueous solution at temperatures from T=288.15K to T=328.15K

“…The C p;2 and B c values, and their uncertainties obtained from the least-squares analyses, are given in table 5. For the data at T = 288.15 K, the value for B c was not statistically different from zero so the value of C p;2 given in table 5 is the mean value of the C p,/ data.…”

“…Since simple second order polynomials do not adequately account for the temperature dependence of C p;2 for peptide model compounds [5,8], no attempts have been made to fit the partial molar heat capacities to suitable functions of temperature. The solid lines in figure 2 have been drawn to illustrate that the C p;2 data lie on smooth curves.…”

“…The determination of various partial molar properties at infinite dilution for aqueous solutions of solutes that model specific structural features of globular proteins has been the focus of our research for many years [1][2][3][4][5][6][7][8][9][10][11]. The main objective of our recent work has been to establish reliable group additivity methods that can be used to calculate the partial molar heat capacities [8,9] and volumes [9,10] of completely unfolded, random coil, proteins in aqueous solution over a wide temperature range.…”

The limiting partial molar volume and transfer partial molar volume of glycylglycine in aqueous sodium halide solutions at 298.15K and 308.15K

“…Most of the previous studies on oligopeptides have been restricted to water [11][12][13][14]. However, biological fluids are not pure water.…”

Thermodynamics of solvation of some small peptides in water at T=298.15K

“…Seminal papers to characterise protein hydration behaviour by using small peptides were published by Lilley and co-workers [1,2]. Thermodynamic studies on amino acids, peptides, neutral amino acid derivatives and cyclic dipeptides are reported in the literature [3][4][5][6][7][8]. In particular, some thermodynamic properties of N-acetylamino acid amides have been investigated by one of us [9,10].…”