Archives of Biochemistry and Biophysics 2015 DOI: 10.1016/j.abb.2015.02.025 View Full Text
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Geneva M. Cunningham, Madeline G. Roman, Lisa C. Flores, Gene B. Hubbard, Adam B. Salmon, Yiqiang Zhang, Jonathan Gelfond, Yuji Ikeno

Abstract: In spite of intensive study, there is still controversy about the free radical or oxidative stress theory of aging, particularly in mammals. Our laboratory has conducted the first detailed studies on the role of thioredoxin (Trx) in the cytosol (Trx1) and in mitochondria (Trx2) on oxidative stress and aging using unique mouse models either overexpressing or down-regulating Trx1 or Trx2. The results generated from our lab and others indicate that: (1) oxidative stress and subsequent changes in signaling pathway…

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