The paradox of high apolipoprotein A-I levels independently predicting incident type-2 diabetes among Turks

Onat, Altan; Hergenç, Gülay; Bulur, Serkan; Uğur, Murat; Küçükdurmaz, Zekeriya; Can, Günay

doi:10.1016/j.ijcard.2008.12.066

Cited by 62 publications

(55 citation statements)

References 35 publications

(33 reference statements)

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“…[10] However, in a Turkish sample population elevated Apo A1 levels individually predicted the incidence of T2DM with top tertile of serum Apo A1 approximately doubled the possibility of T2DM when compared with low tertile. [26] The present study demonstrated a significant increase in Apo B values in T2DM patients as compared to healthy controls. Additionally, a positive correlation was observed between HbA1c and Apo B.…”

Section: Discussionsupporting

confidence: 59%

Apolipoprotein A and Apolipoprotein B Levels Along With Standard Lipid Profile in Type II Diabetes Mellitus Patients in a Tertiary Care Centre in Sub Himalayan Region

Jamwal¹,

Yadav²,

Malik³

2018

AIMDR

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Background: Apolipoprotein A (Apo A) and apolipoprotein B (Apo B) are the key structural components of high density lipoprotein (HDL) particles and atherogenic lipoproteins respectively. The present study was designed to estimate and investigate the role of Apo A and Apo B levels along with standard lipid profile in patients with type 2 diabetes mellitus (T2DM). Methods: The study was carried out on 200 subjects viz. 100 healthy controls and 100 T2DM cases. Whole blood sample was utilized for glycosylated hemoglobin (HbA1c) and serum obtained was analyzed for quantitative estimation of total cholesterol, triglycerides, low density lipoprotein (LDL), HDL, Apo A and Apo B by automated chemistry analyzer. Results: A significant increase (p < 0.005) was observed in the mean HbA1c, cholesterol, triglycerides, LDL and Apo B levels in patients with T2DM as compared to healthy controls. On the contrary, a significant decrease (p < 0.005) was witnessed in the mean HDL and Apo A values of T2DM patients as compared to healthy controls. A positive correlation was seen between HbA1c and total cholesterol (r = 0.427); HbA1c and triglyceride levels (r = 0.281); HbA1c and LDL (r = 0.399); HbA1c and Apo B (r = 0.403). However, a negative correlation was observed between HbA1c and HDL (r = -0.337); HbA1c and Apo A (r = -0.426). Conclusion: There is a high prevalence of dyslipidemia with poorly controlled HbA1c in T2DM patients. Apo A and Apo B assays should be incorporated in the standard lipid profile, for better risk prediction in diabetics and to curtail the risk of future cardiovascular mortality.

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Section: Discussionsupporting

confidence: 59%

Apolipoprotein A and Apolipoprotein B Levels Along With Standard Lipid Profile in Type II Diabetes Mellitus Patients in a Tertiary Care Centre in Sub Himalayan Region

Jamwal¹,

Yadav²,

Malik³

2018

AIMDR

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“…The amount of circulating LDL is reflected by a higher plasma concentration of oxLDL, with about sixfold increase compared to controls [37]. The same hypercholesterolemic plasma environment accounts for an increased expression of Apolipoprotein A1, especially in HF group, as previously reported [38] [39].…”

Section: Circulatory Lipid/lipoproteins and Inflammatory Markerssupporting

confidence: 66%

HDL-Mediated Protection of Coronary Vasodilator Response to Adenosine in the Hypercholesterolemic Swine

Vozzi¹,

Pelosi²,

Puntoni³

et al. 2014

OJMIP

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“…Among 2111 middle-aged and elderly Turkish adults, subjects in the high serum apoA-I tertile had a nearly twofold increased risk for incident diabetes compared with subjects in the low serum apoA-I tertile during a 7.4 year follow-up. The authors of that study speculated that dysfunctional adiponectin associated with systemic inflammation and insulin resistance might transform apoA-I into proinflammatory particles and thus enhance the development of diabetes (9). Another study involving a Finnish cohort showed that apoA-I was an independent risk factor for the development of diabetes during a median 10.8-year follow-up (10).…”

Section: European Journal Of Endocrinologymentioning

confidence: 99%

“…Accordingly, recent epidemiological studies have demonstrated the association between low HDL-C concentrations and the risk of incident type 2 diabetes (T2D) (7,8). By contrast, while little is known about the role of apoA-I in the development of T2D, the findings of some recent studies have suggested that high serum apoA-I is associated with an increased risk of incident diabetes (9,10).…”

Section: Introductionmentioning

confidence: 99%

Association of HDL-C and apolipoprotein A-I with the risk of type 2 diabetes in subjects with impaired fasting glucose

Hwang

Ahn

Park

et al. 2014

European Journal of Endocrinology

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Objectives: HDLs have many diverse functions. The goal of this study was to determine the association of HDL cholesterol (HDL-C) and apolipoprotein A-I (apoA-I) with the development of type 2 diabetes (T2D). In particular, this study determined the association between the ratio of HDL-C to apoA-I (HA) and incident T2D. Design and methods: A total of 27 988 subjects with impaired fasting glucose (IFG) (18 266 men and 9722 women) aged 21-91 years (mean age 40.7 years) were followed for a mean duration of 2.81 years. Results: Study subjects were divided into quartiles according to the baseline HA ratio. Age, male sex, current smoking, BMI, waist circumference, and high-sensitivity C-reactive protein decreased across the quartiles, and all metabolic profiles, including blood pressure, fasting glucose, insulin resistance as determined by homeostasis model assessment of insulin resistance, and lipid measurements such as total cholesterol, LDL cholesterol, non-HDL-C, and apoB, improved as the HA ratio increased. In addition, incident cases of T2D decreased as the HA ratio increased, independent of age, sex, BMI, current smoking, systolic blood pressure, HbA1c, fasting serum insulin, family history of diabetes, and serum triglyceride concentrations (HR (95% CI) of fourth quartile vs first quartile; 0.76 (0.67-0.86), P!0.0001). Conclusions: A higher HA ratio was associated with favorable metabolic profiles and a lower risk of T2D development in subjects with IFG.

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The paradox of high apolipoprotein A-I levels independently predicting incident type-2 diabetes among Turks

Cited by 62 publications

References 35 publications

Apolipoprotein A and Apolipoprotein B Levels Along With Standard Lipid Profile in Type II Diabetes Mellitus Patients in a Tertiary Care Centre in Sub Himalayan Region

Apolipoprotein A and Apolipoprotein B Levels Along With Standard Lipid Profile in Type II Diabetes Mellitus Patients in a Tertiary Care Centre in Sub Himalayan Region

HDL-Mediated Protection of Coronary Vasodilator Response to Adenosine in the Hypercholesterolemic Swine

Association of HDL-C and apolipoprotein A-I with the risk of type 2 diabetes in subjects with impaired fasting glucose

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