The para‐Bombay phenotype in Chinese persons

Abstract

The para-Bombay phenotype occurs more frequently in Oriental than in white populations. This report describes the immunohematologic findings in 20 cases of the para-Bombay phenotype detected over a period of about 15 months in the Chinese population of Taiwan.

Heterogeneity of the Human H Blood Group α (1,2) Fucosyltransferase Gene among Para-Bombay Individuals

“…In addition, all cases have been secretors with normal amounts of ABH substances present in the sali va [13], In this paper, five different h alleles with deletions or missense mutations in the coding region of the H gene identified among the Taiwanese of the para-Bombay pheno type are reported. …”

“…All the H antigen-deficient individuals identified among the Taiwanese are classified as the para-Bombay phenotype, since the RBC A or B antigens in these individuals are usually detectable only by absorption and elution tests with anti-A or anti-B antibodies. In addition, all cases have been secretors with normal amounts of ABH substances present in the saliva [13]. In this paper, five different h alleles with deletions or missense mutations in the coding region of the H gene identified among the Taiwanese of the para-Bombay phenotype are reported.…”

“…Their RBC ABH antigens and serum antibodies were detected by standard hemagglutination and absorption and elu tion tests, and salivary ABH substances were determined by a salivary inhibition study [14]. Samples of 7 of these 8 individuals demonstrated the typical serological reactions of other para-Bombay Taiwanese identified previously [13]. However, the ABH phenotype on RBC of HYTP was different to those of the other seven samples.…”

ABO, H, and Lewis Systems

“…Most H -defi cient secretors have been found in Eastern Asia -Chinese [408,412,441,446] and Japanese [406,409,440] -but also very rarely in other ethnic groups including people of European origin [80,411,443,447] , from the Middle East [80,411] , and a Native American [448] . Some estimated frequencies: one in 5000 Thais [442] , one in 8000 Taiwanese [449] , and one in 15 620 Hong Kong Chinese [441] .…”

AB para-Bombay phenotype: a rare blood group variant and its clinical significance

“…The specificity of the antibodies in the patient's serum is likely to be anti-HI (reacting at 4 °C only), as the serum did not react with group O cord cells (cord cells lack I antigen but carry H antigen) and was not inhibited by group O secretor saliva (anti-H would be inhibited by H substance). 2 Her biological sister's blood group was A 1 B RhD positive.…”