The pancreas and gastric secretion: failure of pancreatectomy to prevent inhibition of gastric secretion by secretin

Kennedy, Joseph C.; Hallenbeck, George A.

doi:10.1136/gut.4.1.58

Cited by 17 publications

(9 citation statements)

References 4 publications

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“…Although the action of secretin on pancreatic secretion is well established, its possible role as a gastric acid inhibitor was first clearly suggested by Greenlee, Longhi, Guerrero, Nelsen, El-Bedri, and Dragstedt (1957) who demonstrated inhibition of food-stimulated gastric secretion in dogs with Heidenhain pouches given secretin intravenously. This work was confirmed recently in dogs (Jordan and Peterson, 1962;Kennedy and Hallenbeck, 1963 …”

supporting

confidence: 76%

“…Free hydrochloric acid concentra-Combined acid, which has been used as a measure of tion was significantly lower after secretin than after reflux (Rovelstad, 1963) , an experimental Period preparation which eliminates pancreatic juice as a 1 2 3 4 5 6 contributory factor. These findings indicate that the secretin effect is a direct one, rather than one The inhibitory effect of secretin has been demonstrated with preparations whose purity differs widely DISCUSSION (Jordan and Peterson, 1962;Kennedy and Hallenbeck, 1963)…”

Section: Resultsmentioning

confidence: 87%

“…collection periods. Free hydrochloric acid concentra-Combined acid, which has been used as a measure of tion was significantly lower after secretin than after reflux (Rovelstad, 1963) The inhibitory effect of secretin has been demonstrated with preparations whose purity differs widely DISCUSSION (Jordan and Peterson, 1962;Kennedy and Hallenbeck, 1963). Both in experiments in dogs and in In these studies in man the intravenous administra-these studies in humans, inhibition occurred with tion of secretin produced a significant inhibition of different preparations, suggesting that inhibition is broth-stimulated gastric secretion.…”

Section: Resultsmentioning

confidence: 99%

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The inhibitory effect of secretin on broth-stimulated gastric secretion in human subjects

Kamionkowski¹,

Grossman²,

Fleshler³

1964

Gut

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EDITORIAL SYNOPSIS The effect of intravenous secretin on broth-stimulated gastric secretion was studied in 10 adult subjects. Secretin significantly inhibited gastric acid concentration and output for at least 30 minutes following administration. These results were not due to neutralization by reflux of pancreatic juice since the volume of gastric aspirate and the combined acid concentration were less with secretin than during the control study. No difference was observed between the degree of inhibition of gastric secretion of two different preparations of secretin. These findings in humans are similar to those reported in dogs and indicate that secretin may have a physiological role in inhibiting gastric secretion.

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supporting

confidence: 76%

Section: Resultsmentioning

confidence: 87%

Section: Resultsmentioning

confidence: 99%

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The inhibitory effect of secretin on broth-stimulated gastric secretion in human subjects

Kamionkowski¹,

Grossman²,

Fleshler³

1964

Gut

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“…Greenlee, Londhi, Guerrero, Nelsen, El-Bedri, and Dragstedt (1957) reported that in dogs intravenous injections of secretin (Lilly) inhibited the response to feeding and to antral pouch stimulation, but not to vagal stimulation or histamine. It was further shown by Kennedy and Hallenbeck (1963) that the inhibitory effect of intravenous secretin was unaffected by removal of the pancreas. Thomford, Kennedy, and Hallenbeck (1963) found that intravenous secretin (Vitrum) failed to reduce the response of a Heidenhain pouch to intragastric ethyl alcohol.…”

Section: Resultsmentioning

confidence: 98%

Inhibitory effect of secretin and cholecystokinin on Heidenhain pouch responses to gastrin extract and histamine

Gillespie¹,

Grossman²

1964

Gut

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MATERIALS AND METHODSFive dogs with Heidenhain type denervated fundic pouches created more than six months previously were studied.Secretin and cholecystokinin, prepared by the method of Jorpes and Mutt (1959), were obtained from Vitrum (Stockholm). Gastrin extract was prepared from hog antral mucosa by a modification of the method of Gregory and Tracy (1961) previously described (Gillespie and Grossman, 1963); doses are expressed as the equivalent weight in grams of wet antral mucosa.The dogs were deprived of food overnight before each test. The inhibitory action of the secretin and cholecystokinin was tested against a background of secretion stimulated by continuous intravenous infusion of gastrin extract or histamine given throughout each experiment by a Sigmamotor pump, the rate of flow being 20 ml. per hour. The concentration of gastrin extract or of histamine dihydrochloride in 0.9% sodium chloride solution was adjusted to give the desired dose rates. After the response had reached a plateau of at least four approximately equal successive 15-minute collections, a single intravenous injection of secretin or cholecystokinin (75 clinical units = 0.1 mg. for secretin, 3 mg. for cholecystokinin) was given and collections were continued at 15-minute intervals for at least one and a half hours.The acid concentration was determined by titration with 0.2N sodium hydroxide with phenol red indicator. The results are given as microequivalents per 15 minutes. The control output is the mean of the four 15-minute outputs immediately preceding the secretin or cholecystokinin injection, each subsequent 15-minute output being expressed as a percentage of the control response. In all instances duplicate observations were made on each dog. RESULTS

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“…A number of papers have indicated that pancreatic duct obstruction [2,3,8,10], pancreatectomy [3,7,18] and pancreatic external fistula produce a gastric hypersecretion from a Heidenhain pouch. The pos tulated mechanism to explain this hypersecretion includes: (a) an increased release of gastrin from the atrophic pancreas and/or the antrum after pan creatic duct obstruction [2,5] and pancreatic external fistula [ 11 ]; (b) a failure of the duodenal inhibitor mechanism induced by fats [10][11][12][13][14][15][16][17], and (c) an impaired hepatic function [14].…”

Section: Discussionmentioning

confidence: 99%

Influence of Pancreatic Secretion on Gastric Secretion in Dogs

Palasciano¹,

Tiscornia²,

Dzieniszewski³

et al. 1974

Digestion

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Canine gastric secretion is significantly decreased after the intraduodenal administration of lyophilized pig pancreas, pancreatic juice and bovine trypsinogen. Conversely, intraduodenal administration of isotonic saline solution, lyophilized pig meat, trypsin and chymotrypsinogen failed to decrease gastric secretion in dogs. It is suggested that the pancreatic juice plays a role in the duodenal inhibition of gastric secretion through the trypsinogen activation peptide.

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The pancreas and gastric secretion: failure of pancreatectomy to prevent inhibition of gastric secretion by secretin

Cited by 17 publications

References 4 publications

The inhibitory effect of secretin on broth-stimulated gastric secretion in human subjects

The inhibitory effect of secretin on broth-stimulated gastric secretion in human subjects

Inhibitory effect of secretin and cholecystokinin on Heidenhain pouch responses to gastrin extract and histamine

Influence of Pancreatic Secretion on Gastric Secretion in Dogs

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