The palladium‐catalyzed C‐N cross‐coupling reaction of diheteroaryl disulfides with heterocyclic amines

Abstract

The Pd‐catalyzed cross‐coupling reaction of 1, 2‐di(pyrimidin‐2‐yl) disulfides with heterocyclic amines including 2‐amino pyrimidines and 1,3,4‐thiadiazol‐2‐amines to deliver symmetrical C‐N coupling products in moderate to good yields is reported. This method provides an opportunity for synthesis of bioactive molecules and pharmaceutically interesting compounds containing heterocycle motifs. The reported protocol shows good functional group compatibility, and provides a new strategy for preparation of C2‐amination pyrimidine derivatives from heterocyclic disulfides.

The thermoregulated ligand–palladium‐catalyzed carbonylative Sonogashira coupling of aryl iodides with terminal alkynes in water

“…Alkylpolyoxyethylenemodified phosphine ligands exhibit an inverse temperature-dependent solubility in water; that is, their aqueous solution will undergo a phase separation on heating to C p and become water soluble again on cooling to a temperature lower than C p . [35][36][37][38] So far, TRPTC has been successfully applied in hydroformylation, [38,39] hydrogenation, [35,40] palladium-catalyzed carbon-carbon crosscoupling reactions, [41][42][43][44] and so on. [45] In spite of significant advances in this area, there are very few reports of employing TRPTC systems for carbonylative coupling reactions.…”