The Paleolithic Diet

Singh, Annapoorna; Singh, Daulath

doi:10.7759/cureus.34214

Cited by 8 publications

(10 citation statements)

References 19 publications

(25 reference statements)

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“…AMMPER is open-source software and publicly available through NASA GitHub 39 . The version presented here may be seen as an initial framework whose parameters and modules may be modified and improved upon in the future to accommodate other organisms and data types, and to simulate chemical and biological processes with better fidelity.…”

Section: Resultsmentioning

confidence: 99%

“…We began with information from subject matter experts and from the scientific literature to build an initial model capturing only what we hypothesized to be the salient features of these processes--those that would contribute to the features we wanted to recapitulate. AMMPER is open-source software and publicly available through NASA GitHub 39 . The version presented here may be seen as an initial framework whose parameters and modules may be modified and improved upon in the future to accommodate other organisms and data types, and to simulate chemical and biological processes with better fidelity.…”

Section: Modeling Approachmentioning

confidence: 99%

“…The code for AMMPER developed in this study is freely available on the NASA GitHub Repository (https://github.com/nasa/AMMPER) 39 .…”

Section: Code Availabilitymentioning

confidence: 99%

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Agent-based Model for Microbial Populations Exposed to Radiation (AMMPER) simulates yeast growth for deep-space experiments

Singh,

Santa Maria,

Gentry

et al. 2023

Preprint

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Space radiation poses a substantial health risk to humans traveling beyond Earth’s orbit to the Moon and Mars. As microbes come with us to space as model organisms for studying radiation effects, a computational model simulating those effects on microorganisms could enable us to better design and interpret those experiments. Here we present Agent-based Model for Microbial Populations Exposed to Radiation (AMMPER), which simulates the effects of protons, a major component of deep-space radiation, on budding yeast (Saccharomyces cerevisiae) growth. The model combines radiation track structure data from the RITRACKS package with novel algorithms for cell replication, motion, damage, and repair. We demonstrate that AMMPER qualitatively reproduces the effects of 150 MeV proton radiation on growth rate, but not lag time, of wild type and DNA repair mutant yeast strains. The variance in AMMPER’s results is consistent with the variance in experimental results, suggesting that AMMPER can recapitulate the stochasticity of empirical experiments. Finally, we used AMMPER to predict responses to deep space radiation that may be tested in future experiments. A user-friendly, open-source, extendable Python package for studying the relationship between single-particle radiation events and population-level responses, AMMPER can facilitate the basic research necessary to ensure safe and sustainable exploration of deep space.

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Section: Resultsmentioning

confidence: 99%

Section: Modeling Approachmentioning

confidence: 99%

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Agent-based Model for Microbial Populations Exposed to Radiation (AMMPER) simulates yeast growth for deep-space experiments

Singh,

Santa Maria,

Gentry

et al. 2023

Preprint

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“…The Paleolithic diet, commonly referred to as a hunter-gatherer diet or stone-age diet, is a presumed dietary pattern that is believed to have been common among people living in the Paleolithic era, which occurred from 2.5 million to 10,000 years ago. The diet promotes the intake of meat, fish, eggs, vegetables, fruits, roots, and nuts, while excluding many produced items like dairy products, oils, cereals, legumes, salt, and processed sugars [53,54].…”

Section: Paleolithic Dietmentioning

confidence: 99%

A Narrative Review of the Significance of Popular Diets in Diabetes Mellitus Management

Şahin Bayram

2024

Cureus

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Diabetes mellitus is a collection of metabolic disorders marked by elevated levels of glucose in the blood due to irregularities in the generation or functioning of insulin. Medical nutrition therapy and weight loss are crucial elements in the management of diabetes and the prevention of complications. Several diets have become popular over time for the goal of achieving weight loss, but their popularity has declined due to a lack of reliable scientific evidence.This study classifies popular diets into three categories: diets that manage the composition of macronutrients, diets that restrict specific foods or food groups, and diets that manipulate meal timing. The review includes research studies that investigated the effects of popular diets on the prevention, management, and complications of diabetes.It is clear that different popular diets can have positive effects on both preventing and treating diabetes and preventing and treating complications related to diabetes. However, it is not practical to determine which diet is the most effective option for preventing or controlling diabetes. Thus, the main focus should be on common underlying factors that support well-being, such as decreasing the intake of refined grains and added sugar, choosing non-starchy vegetables, and giving priority to whole foods over processed foods whenever possible, until there is stronger evidence supporting the specific benefits of different dietary patterns.

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“…Additionally, vegans have a greater prevalence of mental health problems, which may lead to a poorer quality of life. An optimal diet should be balanced, consisting of lean meat, nuts, fresh fruits and vegetables, and olive oil (Figure 1) [8,9]. A wholesome diet is essential in maintaining a healthy gut flora, which in turn is pivotal in avoiding inflammatory disorders [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

The Impact of a Vegan Diet on Many Aspects of Health: The Overlooked Side of Veganism

Bali¹,

Naik²

2023

Cureus

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Vegetarianism in any of its various forms, particularly veganism, has been increasing in popularity over the past few years, especially among the young population in the United States. While several studies have shown that a vegan diet (VD) decreases the risk of cardiometabolic diseases, such as cardiovascular disease, type 2 diabetes mellitus, obesity, and non-alcoholic fatty liver disease, veganism has been associated with adverse health outcomes, namely, nervous, skeletal, and immune system impairments, hematological disorders, as well as mental health problems due to the potential for micro and macronutrient deficits. The goal of this review article is to discuss the current literature on the impact and long-term consequences of veganism on vulnerable populations, including children, adolescents, pregnant and breastfeeding women, and fetal outcomes in strict vegan mothers. It also focuses on the many deficiencies of the vegan diet, especially vitamin B12, and the related increased risk of malignancies.

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The Paleolithic Diet

Cited by 8 publications

References 19 publications

Agent-based Model for Microbial Populations Exposed to Radiation (AMMPER) simulates yeast growth for deep-space experiments

Agent-based Model for Microbial Populations Exposed to Radiation (AMMPER) simulates yeast growth for deep-space experiments

A Narrative Review of the Significance of Popular Diets in Diabetes Mellitus Management

The Impact of a Vegan Diet on Many Aspects of Health: The Overlooked Side of Veganism

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