The P3a wave: A reliable neurophysiological measure of Parkinson’s disease duration and severity

Solís-Vivanco, Rodolfo; Rodríguez-Violante, Mayela; Rodríguez-Agudelo, Yaneth; Schilmann, Astrid; Rodríguez-Ortiz, Ulises; Ricardo-Garcell, Josefina

doi:10.1016/j.clinph.2014.12.024

Cited by 59 publications

(72 citation statements)

References 59 publications

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“…Another recent finding that underscores the functional relevance of P3a in PD has been reported by Solís-Vivanco et al (2015). These authors found the degree of P3a amplitude attenuation in 55 PD patients to be linearly related to disease duration, even when controlling for covariates such as age and MMSE score.…”

Section: P3b In Pd: Conclusion and Future Directionsmentioning

confidence: 71%

“…These authors found the degree of P3a amplitude attenuation in 55 PD patients to be linearly related to disease duration, even when controlling for covariates such as age and MMSE score. This finding has been suggested to indicate that P3a amplitude may qualify as a reliable biomarker of disease progression (Solís-Vivanco et al, 2015).…”

Section: P3b In Pd: Conclusion and Future Directionsmentioning

confidence: 78%

“…Studies should be conducted in large samples to obtain a reliable estimate of the effect sizes. One study (Solís-Vivanco et al, 2015) reported an association between P3a amplitude attenuation and disease duration in PD. Future studies employing longitudinal designs are required to examine the utility of P3a amplitude as a biomarker of disease progression in PD.…”

Section: P3a Mmn and Ron In Pd: Conclusion And Future Directionsmentioning

confidence: 99%

See 2 more Smart Citations

Event-related potentials and cognition in Parkinson’s disease: An integrative review

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Georgiev

et al. 2016

Neuroscience & Biobehavioral Reviews

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Section: P3b In Pd: Conclusion and Future Directionsmentioning

confidence: 71%

Section: P3b In Pd: Conclusion and Future Directionsmentioning

confidence: 78%

Section: P3a Mmn and Ron In Pd: Conclusion And Future Directionsmentioning

confidence: 99%

See 1 more Smart Citation

Event-related potentials and cognition in Parkinson’s disease: An integrative review

Seer

Lange

Georgiev

et al. 2016

Neuroscience & Biobehavioral Reviews

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“…Future research may further examine how N e /ERN amplitudes relate to the clinical and psychological profile of PD patients and determine its usefulness as a marker, e.g., for disease progression or for the development of non-motor symptoms, such as depression or executive dysfunction. ERP measures have already been proposed to be promising in this respect, both in Parkinson’s disease4243 and in other neurological disorders4445464748, where motor symptoms are likely to distort the results of other imaging techniques or neuropsychological testing.…”

Section: Discussionmentioning

confidence: 99%

Dopaminergic modulation of performance monitoring in Parkinson’s disease: An event-related potential study

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Lange

Loens

et al. 2017

Sci Rep

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Monitoring one’s actions is essential for goal-directed performance. In the event-related potential (ERP), errors are followed by fronto-centrally distributed negativities. These error(-related) negativity (Ne/ERN) amplitudes are often found to be attenuated in patients with Parkinson’s disease (PD) compared to healthy controls (HC). Although Ne/ERN has been proposed to be related to dopaminergic neuronal activity, previous research did not find evidence for effects of dopaminergic medication on Ne/ERN amplitudes in PD. We examined 13 PD patients “on” and “off” dopaminergic medication. Their response-locked ERP amplitudes (obtained on correct [Nc/CRN] and error [Ne/ERN] trials of a flanker task) were compared to those of 13 HC who were tested twice as well, without receiving dopaminergic medication. While PD patients committed more errors than HC, error rates were not significantly modulated by dopaminergic medication. PD patients showed reduced Ne/ERN amplitudes relative to HC; however, this attenuation of response-locked ERP amplitudes was not specific to errors in this study. PD-related attenuation of response-locked ERP amplitudes was most pronounced when PD patients were on medication. These results suggest overdosing of dopaminergic pathways that are relatively spared in PD, but that are related to the generation of the Ne/ERN, notably pathways targeted on the medial prefrontal cortex.

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“…Also further analysis on the ERP data showed that in our sample, burnout severity was not sufficient to predict the amount of attenuation of the P3 response. responses in a simple target detection task (Knight, 1997), and Parkinson's disease showing decreased auditory P3a responses (Solís-Vivanco et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Shifting of attentional set is inadequate in severe burnout: Evidence from an event-related potential study

Sokka

Leinikka

Korpela

et al. 2017

International Journal of Psychophysiology

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Individuals with prolonged occupational stress often report difficulties in concentration. Work tasks often require the ability to switch back and forth between different contexts. Here, we studied the association between job burnout and task switching by recording event-related potentials (ERPs) time-locked to stimulus onset during a task with simultaneous cue-target presentation and unpredictable switches in the task. Participants were currently working people with severe, mild, or no burnout symptoms. In all groups, task performance was substantially slower immediately after task switch than during task repetition. However, the error rates were higher in the severe burnout group than in the mild burnout and control groups. Electrophysiological data revealed an increased parietal P3 response for the switch trials relative to repetition trials. Notably, the response was smaller in amplitude in the severe burnout group than in the other groups. The results suggest that severe burnout is associated with inadequate processing when rapid shifting of attention between tasks is required resulting in less accurate performance.

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The P3a wave: A reliable neurophysiological measure of Parkinson’s disease duration and severity

Cited by 59 publications

References 59 publications

Event-related potentials and cognition in Parkinson’s disease: An integrative review

Event-related potentials and cognition in Parkinson’s disease: An integrative review

Dopaminergic modulation of performance monitoring in Parkinson’s disease: An event-related potential study

Shifting of attentional set is inadequate in severe burnout: Evidence from an event-related potential study

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