The P300 ERP component: an index of cognitive dysfunction xin depression?

Sara, Grant; Gordon, Evian; Kraiuhin, Claudia; Coyle, S. T.; Howson, Alan; Meares, Russell

doi:10.1016/0165-0327(94)90124-4

Cited by 60 publications

(35 citation statements)

References 42 publications

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“…A probable explanation for this negative correlation is that on the button-press, the task load is decreased when compared to the silent-count for the same group of patients. A prolonged P300 latency has also been reported in few studies on depression [30]. In terms of a positive correlation between SDS and P300 latency in the silent-count paradigm in this study may include similar mechanism that increased load increases latency.…”

Section: Discussionsupporting

confidence: 50%

“…One study has found a 26% rate of major depression among acute head trauma patients, and of those patients who were not acutely depressed, 27% went on to develop major depressive episodes within one year [12]. Studies have also shown disturbances in auditory event-related potential (ERP) in some patients with major depression [13], but not in all; only a few studies report a prolonged P300 latency in depression [14]. However, ERPs provide important information about central nervous system activity in conjunction with psychological events.…”

Section: (Text)mentioning

confidence: 99%

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Correlations between neuropsychological test results and P300 latency during silent-count and button-press tasks in post-traumatic brain injury patients

Reza

Ikoma

Chuma

et al. 2006

Journal of Clinical Neuroscience

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Abstract:To evaluate the correlations between memory function and intelligence and event-related potential, the P300 component for different tasks was studied for 30 post-traumatic brain injury patients (mean age 31.6 ± 13.7 years; 23 male and 7 female). Memory function, intelligence, and depression were measured by using the Mini-Mental State Examination, the revised Wechsler Adult Intelligence Scale and the Self-Rating Depression Scale, respectively. P300 latency was measured during silent-count and button-press tests at three midline scalp (Fz, Cz, and Pz) sites for all subjects by using an auditory 'odd-ball' paradigm. Neuropsychological memory score was predicted by intelligence score, but neurophysiological P300 latency was predicted by memory score for the silent-count test and by intelligence score for the button-press test. These results show that the P300 event-related potential component is sensitive to the diverse nature of cognitive deficits in post-traumatic brain injury patients during different types of discrimination tasks.However, future research is necessary to replicate and extend these findings.

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Section: Discussionsupporting

confidence: 50%

Section: (Text)mentioning

confidence: 99%

Correlations between neuropsychological test results and P300 latency during silent-count and button-press tasks in post-traumatic brain injury patients

Reza

Ikoma

Chuma

et al. 2006

Journal of Clinical Neuroscience

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“…Although a number of studies have examined the impact of clinical depression on selective attention, studies have tended to focus on specific ERP components to targets (often only the P300) and to ignore responses elicited to background stimuli, making it unclear whether attentional impairment in depression commences prior to voluntary response to stimuli and associated P300 response. Other findings have been reported for clinically depressed participants comprising a reduction in N100 amplitude in response to both target and non-target stimuli [Burkhart and Thomas, 1993;el Massioui and Lesevre 1988;Hansenne et al, 1996;Roth et al, 1981], and increases in the P200 component [Sara et al, 1994;Vandoolaeghe et al, 1998], consistent with our findings in non-clinical depression, which focused on participants classified as non-depressed, mild-moderately or severely depressed [Kemp et al, 2006]. In our study, while no differences in behavioural performance was observed, we found that the mild-moderately depressed group was distinguished by increased P200 amplitude to targets relative to the other groups, along with decreased N100 amplitude compared to the non-depressed group.…”

Section: Introductionmentioning

confidence: 91%

Fronto‐temporal alterations within the first 200 ms during an attentional task distinguish major depression, non‐clinical participants with depressed mood and healthy controls: A potential biomarker?

Kemp¹,

Hopkinson²,

Hermens³

et al. 2009

Human Brain Mapping

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Attentional impairment in depression is a cardinal feature of depression and has been proposed as a candidate endophenotype for major depressive disorder. Event-related potentials (ERPs) elicited by oddball signal detection tasks provide objective markers of selective stimulus processing, and are pertinent endophenotypic markers for depression. While previous studies have sought to determine objective markers for attentional impairment in depression, evidence is inconsistent and may involve heterogeneity in relatively small samples. Here, we brought together oddball ERP recording with source localization of neural correlates of selective attention in outpatients with major depressive disorder (MDD; n = 78) and participants with depressed mood (PDM; n = 127) relative to healthy controls (CTL; n = 116). The key finding was a dimensional exaggeration of the P200 (140-270 ms) to both target (signal) and non-target (noise) stimuli, most pronounced in MDD, followed by PDM, relative to CTL. This exaggeration was coupled with slower and more variable response times, suggesting that neural systems are attempting to compensate for a difficulty in discriminating signal from noise. P200 alterations were localised to limbic (hippocampal), temporal and ventral prefrontal regions, key components of the signal detection network. A subsequent reduction and delay in the P300 was also revealed for MDD indicating that the pronounced lack of discrimination in clinical depression may also lead to impaired stimulus evaluation. This P200 increase in depression could provide a potential mechanism for the attentional impairment frequently observed in depression and consequent alterations in the P300 may differentiate clinically significant depression.

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“…Numerous event-related brain potential (ERP) studies suggested that depressive patients exhibited deficits in attention and memory processes [17][18][19][20][21] . The ERP paradigm we used for exploring memory processing was a continuous word recognition test, in which correctly classified old items elicit more positive-going waveforms than new items after word presentation (e.g.…”

Section: Introductionmentioning

confidence: 99%

S100B Serum Levels and Word Memory Processing in Remitted Major Depression as Reflected by Brain Potentials

Zhang

Rothermundt²,

Peters³

et al. 2009

Neuropsychobiology

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Objective: Memory processes, as reflected by ‘old/new’ effects of event-related potentials (ERPs), have been shown to be impaired in depressed patients. This variability might be partly explained by biological factors. S100B is a glial calcium-binding protein with neuroplastic properties; S100B serum levels have been shown to be increased in depressive patients. The pathophysiologic role of S100B in depression, however, is not yet sufficiently understood. Methods: In the present study, ERPs recorded in a visual continuous word recognition paradigm were therefore investigated in patients with remitted major depression in relation to S100B serum levels. Results: Patients with moderately increased S100B serum levels (n = 6) showed a normal old/new effect in contrast to a reduced old/new effect in patients with normal S100B levels (n = 6) compared to aged-matched controls. Conclusions: These findings provide evidence of an association between S100B levels and memory processes in patients with recurrent depression and further suggest a neuroprotective role of moderately increased S100B serum levels in the course of affective disorders.

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The P300 ERP component: an index of cognitive dysfunction xin depression?

Cited by 60 publications

References 42 publications

Correlations between neuropsychological test results and P300 latency during silent-count and button-press tasks in post-traumatic brain injury patients

Correlations between neuropsychological test results and P300 latency during silent-count and button-press tasks in post-traumatic brain injury patients

Fronto‐temporal alterations within the first 200 ms during an attentional task distinguish major depression, non‐clinical participants with depressed mood and healthy controls: A potential biomarker?

S100B Serum Levels and Word Memory Processing in Remitted Major Depression as Reflected by Brain Potentials

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