The P2Y2 receptor mediates terminal adipocyte differentiation and insulin resistance: Evidence for a dual G-protein coupling mode

Qian, Shenqi; Shi, Yi; Senfeld, Jared; Peng, Qianman; Shen, Jianzhong

doi:10.1016/j.jbc.2023.105589

Journal of Biological Chemistry

2024

DOI: 10.1016/j.jbc.2023.105589

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The P2Y2 receptor mediates terminal adipocyte differentiation and insulin resistance: Evidence for a dual G-protein coupling mode

Shenqi Qian,

Yi Shi,

Jared Senfeld

et al.

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ER-transiting bacterial toxins amplify STING innate immune responses and elicit ER stress

Schlenker,

Richard,

Skobelkina

et al. 2024

Infect Immun

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The cGAS/STING sensor system drives innate immune responses to intracellular microbial double-stranded DNA (dsDNA) and bacterial cyclic nucleotide second messengers (e.g., c-di-AMP). STING-dependent cell-intrinsic responses can increase resistance to microbial infection and speed pathogen clearance. Correspondingly, STING activation and signaling are known to be targeted for suppression by effectors from several bacterial pathogens. Whether STING responses are also positively regulated through sensing of specific bacterial effectors is less clear. We find that STING activation through dsDNA, by its canonical ligand 2′-3′ cGAMP, or the small molecule DMXAA is potentiated following intracellular delivery of the AB 5 toxin family member pertussis toxin from Bordetella pertussis or the B subunit of cholera toxin from Vibrio cholerae . Entry of pertussis toxin or cholera toxin B into mouse macrophages triggers markers of endoplasmic reticulum (ER) stress and enhances ligand-dependent STING responses at the level of STING receptor activation in a manner that is independent of toxin enzymatic activity. Our results provide an example in which STING responses integrate information about the presence of relevant ER-transiting bacterial toxins into the innate inflammatory response and may help to explain the in vivo adjuvant effects of catalytically inactive toxins.

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ER-transiting bacterial toxins amplify STING innate immune responses and elicit ER stress

Schlenker,

Richard,

Skobelkina

et al. 2024

Infect Immun

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show abstract

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The P2Y2 receptor mediates terminal adipocyte differentiation and insulin resistance: Evidence for a dual G-protein coupling mode

Cited by 1 publication

References 38 publications

ER-transiting bacterial toxins amplify STING innate immune responses and elicit ER stress

ER-transiting bacterial toxins amplify STING innate immune responses and elicit ER stress

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