The P-type ATPase inhibiting potential of polyoxotungstates

Gumerova, Nadiia I.; Krivosudský, Lukáš; Fraqueza, Gil; Breibeck, Joscha; Al-Sayed, Emir; Tanuhadi, Elias; Bijelic, Aleksandar; Fuentes, Juan; Aureliano, Manuel; Rompel, Annette

doi:10.1039/c7mt00279c

Cited by 33 publications

(39 citation statements)

References 46 publications

(66 reference statements)

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“… 6 , 9 With targeted and reproducible synthetic routes, it is nowadays possible to obtain tailor-made POM systems, including organic–inorganic hybrids and other nanocomposites, with enhanced biological properties. 10 – 17 The foundation for the research of biologically active POMs has been laid in 1970, when Chermann et al discovered the inhibitory effect of silicotungstic acid on murine leukaemia and sarcoma viruses. 18 This led to systematic studies of the antiviral effect of this and other POMs revealing that enzyme inhibition ( e.g.…”

Section: Introductionmentioning

confidence: 99%

The antibacterial activity of polyoxometalates: structures, antibiotic effects and future perspectives

2018

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Section: Introductionmentioning

confidence: 99%

The antibacterial activity of polyoxometalates: structures, antibiotic effects and future perspectives

2018

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“…Although the number of POM studies with anticancer effects is increasing, their mechanisms of action in each type of cancer cell are still far from being understood [3]. The antitumor activity of these inorganic compounds seems to be caused, at least in part, by the inhibition of certain enzymes such as alkaline phosphatases, kinases, ecto-nucleotidases, glucosidases, and P-type ATPases [5][6][7][8]. Moreover, some POMs are also understood to interfere with mitochondria function and DNA, while others can exert an immunomodulatory activity [9,10].…”

Section: Introductionmentioning

confidence: 99%

The Aquaporin-3-Inhibiting Potential of Polyoxotungstates

Pimpão

Silva

Mósca

et al. 2020

IJMS

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Polyoxometalates (POMs) are of increasing interest due to their proven anticancer activities. Aquaporins (AQPs) were found to be overexpressed in tumors bringing particular attention to their inhibitors as anticancer drugs. Herein, we report for the first time the ability of polyoxotungstates (POTs), such as of Wells–Dawson P2W18, P2W12, and P2W15, and Preyssler P5W30 structures, to affect aquaporin-3 (AQP3) activity and impair melanoma cell migration. The tested POTs were revealed to inhibit AQP3 function with different effects, with P2W18, P2W12, and P5W30 being the most potent (50% inhibitory concentration (IC50) = 0.8, 2.8, and 3.2 µM), and P2W15 being the weakest (IC50 > 100 µM). The selectivity of P2W18 toward AQP3 was confirmed in yeast cells transformed with human aquaglyceroporins. The effect of P2W12 and P2W18 on melanoma cells that highly express AQP3 revealed an impairment of cell migration between 55% and 65% after 24 h, indicating that the anticancer properties of these compounds may in part be due to the blockage of AQP3-mediated permeability. Altogether, our data revealed that P2W18 strongly affects AQP3 activity and cancer cell growth, unveiling its potential as an anticancer drug against tumors where AQP3 is highly expressed.

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“…According to our previous work, the main chemical reaction of vanadium extraction in the roasting process [18] is illustrated in Equation (5). It can be inferred that the essence of vanadium extraction with roasting was the conversion of vanadium-bearing magnetite to hematite, and the crystal transformation relationship of vanadium-bearing magnetite (FeO(Fe,V) 2 O 3 ) to hematite (α-Fe 2 O 3 ) is illustrated in Figure 6.…”

Section: Crystal Transformation Of Vanadium-bearing Magnetite In the mentioning

confidence: 90%

“…Vanadium is an important rare metal that plays important roles in the steel, aviation, chemical, battery, medicine, and other industries due to its superior characteristics [1][2][3][4][5]. China's vanadium resources mainly exist in two forms: vanadium-containing shale and vanadium-titanium magnetite [6].…”

Section: Introductionmentioning

confidence: 99%

Mechanism of Novel K2SO4/KCl Composite Roasting Additive for Strengthening Vanadium Extraction from Vanadium–Titanium Magnetite Concentrate

Liu

Zhang

et al. 2018

Minerals

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In this paper, a novel K2SO4/KCl composite roasting additive was used to extract vanadium from vanadium–titanium magnetite concentrate. Further, the mechanism of K2SO4/KCl for extracting vanadium was studied. The results indicate that the vanadium leaching efficiency reached 82.04%, an increase of 7.43% compared to that of single K2SO4 and 10.05% compared to single KCl under the following conditions: a total dosage of K2SO4/KCl of 7 wt % with a mass ratio of 6/4, a roasting temperature of 950 °C, a roasting time of 1 h, a leaching temperature of 95 °C, a sulfuric acid concentration of 10% (v/v: volume percentage), and a leaching time of 1.5 h with a liquid-to-solid ratio of 3 mL/g. Moreover, crystal chemistry analyses indicated that the essence of the vanadium extraction with roasting was the conversion of cubic crystal systemic vanadium-bearing magnetite (FeO(Fe,V)2O3) to trigonal crystal systemic hematite (α-Fe2O3), and as most Fe(V)–O bonds were broken with the reconstructed conversion, the dissociation of V(III) occurred. Furthermore, the main decomposition products of K2SO4/KCl were K2O, SO2, and Cl2. X-ray diffraction (XRD) and related SEM-EDS analyses indicated that there were mainly three aspects in the mechanism of K2SO4/KCl for extracting vanadium. Firstly, activated K2O could combine with vanadium to generate soluble KVO3 rather insoluble Ca(VO3)2; secondly, SO2 could react with CaO to form CaSO4 to prevent the generation of acid-consuming Ca(VO3)2, which was beneficial to the dissolution of vanadium-bearing sphene (Ca(Ti,V)SiO4O); thirdly, Cl2 could destroy the structure of hematite (Fe2O3) to reduce its wrapping extent to KVO3.

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The P-type ATPase inhibiting potential of polyoxotungstates

Abstract: Polyoxometalates (POMs) are transition metal complexes that exhibit a broad diversity of structures and properties rendering them promising for biological purposes.

Cited by 33 publications

References 46 publications

The antibacterial activity of polyoxometalates: structures, antibiotic effects and future perspectives

The antibacterial activity of polyoxometalates: structures, antibiotic effects and future perspectives

The Aquaporin-3-Inhibiting Potential of Polyoxotungstates

Mechanism of Novel K2SO4/KCl Composite Roasting Additive for Strengthening Vanadium Extraction from Vanadium–Titanium Magnetite Concentrate

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