The Oxygen Dissociation Curve in Anemia Of Various Types1

Oxygen Dissociation Curves in Sickle Cell Anemia and in Subjects With the Sickle Cell Trait

“…Other workers have reported a similar shift to the right of the dissociation curve in various types of anemia even when the cell pH, carefully controlled, is comparable to that of the normal curves used in comparison (11)(12)(13). Dill and his coworkers (11) produced evidence to show that in pernicious anemia there was certainly a relative alkalosis of the serum and probably relative acidosis of the cells.…”

Haemoglobin and Erythrocyte Potassium Types in Sheep and their Influence on Oxygen Dissociation and Haemoglobin Denaturation

“…It thus appears that the factor or factors giving rise to the differences in oxygen dissociation curves between potassium types are associated with the intact erythrocyte. Kennedy and Valtis (1954) attributed most of the change in the oxygen dissociation curve, which they observed in anaemias, to an alteration in erythrocyte pH. It is possible therefore that differences in the dissociation curves of HK blood ,and LK blood could be due to differences in the internal pH of the two types of erythrocytes.…”

“…Evans (1954) has shown that sheep may also be classified into at least two groups on the basis of their erythrocyte potassium and sodium concentrations, high potassium (HK) animals having an erythrocyte potassium concentration ([Kt]) of 70-95 m-equiv/l, and low potassium (LK) animals 8-26 m-equiv/l. Kennedy and Valtis (1954) and Henderson (1928) have shown that in certain anaemias haemoglobin has a lessened affinity for oxygen, and Williams et al (19:37) have demonstrated an increase in erythrocyte potassium in anaemia.…”

Effect of 2,3-diphosphoglycerate on oxygen affinity of blood in sickle cell anemia

“…The oxygen affinity of blood is decreased in persons residing at high altitudes, and in patients with hypoxemic and anemic hypoxia (11,12,15,26). It has been suggested that this shift in the position of the oxygen dissociation curve helps to maintain an adequate supply of oxygen to the tissues (27).…”