The Oxidative Ammonolysis of Organic Compounds

Suvorov, B. V.; Rafikov, S. R.; Кагарлицкий, А. Д.

doi:10.1070/rc1965v034n09abeh001549

Cited by 11 publications

(7 citation statements)

References 1 publication

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“…The substrate is vaporized in this process. This process has been improved with the development of various catalysts, for example, binary oxides containing molybdenum such as Fe 2 O 3 -MoO 3 and TeO 2 -MoO 3 [5], vanadium oxide species [6], and iron phosphate [7][8][9]. Although this process can be used to obtain high productivity of pyruvate from lactate, the process requires a reaction temperature of 473-573 K to vaporize lactate as a starting material, leading to a large running cost.…”

Section: Introductionmentioning

confidence: 98%

Enhanced production of ethyl pyruvate using gas–liquid slug flow in microchannel

Yasukawa¹,

Ninomiya²,

Ooyachi³

et al. 2011

Chemical Engineering Journal

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a b s t r a c tThe use of a gas-liquid slug flow in a microreactor has several advantages such as a large surface area for contacting gas and liquid phases and circulation flow inside slugs. These advantages accelerate the mass transfer between the two phases, resulting in a high concentration of dissolved gas. The enhanced mass transfer is useful in carrying out liquid phase oxidation that uses oxygen gas as the oxidizing agent. The gas-liquid slug flow in a microreactor system is applied to the oxidation of ethyl lactate using an oxyvanadium species for producing ethyl pyruvate. The reactor system includes two T-shaped micromixers: one for mixing the substrate with a catalyst solution and the other for generating slug flow by the addition of oxygen. The oxidation reaction proceeds right after the slug flow is generated in the second mixer, because the substrate and the catalyst mix rapidly in the first micromixer. Moreover, a high concentration of dissolved oxygen due to improved mass transfer in slug flow increases the oxidation reaction rate. Therefore, compared to a batch reaction, the synthesis using slug flow provides high yields of ethyl pyruvate per unit time and achieves satisfactory productivity at the reaction temperature of 323 K, which is lower than that employed in conventional syntheses. The proposed system enables the production of ethyl pyruvate using a simple reactor setup with reduced energy consumption.

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Section: Introductionmentioning

confidence: 98%

Enhanced production of ethyl pyruvate using gas–liquid slug flow in microchannel

Yasukawa¹,

Ninomiya²,

Ooyachi³

et al. 2011

Chemical Engineering Journal

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“…[1][2][3] Oxidative ammonolysis of mono-and dimethylpyridines is the most rational method for obtaining mono-and dicyanopyridines. 4,5 Oxidative ammonolysis of dialkylpyridines of the unsymmetrical structure showed that alkyl groups at positions 2 and 4 are more reactive than in positions 3 and 5. 6 Therefore, the primary product of the conversion of 2,3-dimethylpyridine on the V-Sn-Fe oxide catalyst is 2-cyano-3-methylpyridine.…”

Section: Introductionmentioning

confidence: 99%

Oxidative ammonolysis of 3,4-dimethylpyridine on the vanadium oxide catalysts

Vorobyev¹,

Serebryanskaya²,

Yugay³

et al. 2020

JSCS

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Oxidative ammonolysis of 3,4-dimethylpyridine on an individual vanadium oxide (V 2 O 5 ) catalyst and binary vanadium oxide catalysts, modified by additions of SnO 2 and ZrO 2 , has been studied. A connection between СНacidity of the methyl groups of the substrate in the gaseous phase and in the chemosorbed state and the sequence of their transformation into a cyano group has been established. It has been shown that nucleophilicity of vanadyl oxygen, calculated by the Density Functional Theory method, increases with V 2 O 5 modification by SnO 2 and ZrO 2 additions. Herewith, an increasing yield of 3methyl-4-cyanopyridine and imide of pyridine-3,4-dicarboxylic acid was observed. A proposed mechanism of the imide of pyridine-3,4-dicarboxylic acid formation has been discussed

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“…Introduction. The reaction of oxidative ammonolysis of methylpyridines is the simplest and most convenient method for the synthesis of cyanopyridines [1], which is used as intermediates for the preparation of drugs [2]. 4-cyanopyridine (isonicotinic acid nitrile) obtained by oxidative ammonolysis of 4-methylpyridine is widely used for the production of pharmaceuticals, including anti-tuberculosis drugs, such as thiazide, isoniazid, saluzidum, and others [2], which are necessary for the Republic of Kazakhstan.…”

mentioning

confidence: 99%

Oxidative Ammonolysis of 4-Methylpyridine on Oxide Vanadium-Titanium-Zirconium Catalyst Modified by Tin and Tungsten Oxides

Mikhailovskaya

Kurmakyzy

Tolemisova³

et al. 2021

Chem. J. of Kaz.

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Catalysts based on vanadium pentoxide modified by Ti, Sn, Zr and W oxides were tested in the oxidative ammonolysis of 4-methylpyridine. The role of the main process parameters such as temperature, the ratio of the initial components in the conversion of the methyl group to the nitrile one, and the optimal conditions for the oxidative ammonolysis of 4-methylpyridine were determined. It is determined that the V-Ti-Zr-O-catalyst and the sample containing 9% of tungsten oxide are superior in catalytic activity to the V-Ti-Zr-Sn-O contact. Conditions that ensure a high selectivity for the formation of 4-cyanopyridine were found. The highest yield of the target product (85-86%) was obtained on V-Ti-Zr-W-O at 270 °C, and the yield of 4-cyanopyridine was 87.5% at 310° C on the V-Ti-Zr-Sn-O catalyst. The phase composition and structural changes occurring in modified vanadium oxide catalysts have been studied. It is determined that mixed V-Ti-Zr-Sn-O and V-Ti-Zr-W-O catalysts contain ZrV2O7, the monoclinic modification of ZrO2 (baddeleyite), TiO2 (anatase), SnO2, WO3, and V2O5. In catalysts, it can exist in small amounts as a separate VO2 phase. The V-Ti-Zr-W-O catalyst showed the best catalytic properties. It has highactivity and selectivity towards 4-cyanopyridine.

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The Oxidative Ammonolysis of Organic Compounds

Abstract: A method for the calculation of generating functions with non-Gaussian distributions is introduced. The method uses the Pad6 approximant technique for series of Stieltjes.

Cited by 11 publications

References 1 publication

Enhanced production of ethyl pyruvate using gas–liquid slug flow in microchannel

Enhanced production of ethyl pyruvate using gas–liquid slug flow in microchannel

Oxidative ammonolysis of 3,4-dimethylpyridine on the vanadium oxide catalysts

Oxidative Ammonolysis of 4-Methylpyridine on Oxide Vanadium-Titanium-Zirconium Catalyst Modified by Tin and Tungsten Oxides

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