The Ovary

Schreiner, W. E.

doi:10.1007/978-3-642-96158-8_10

Cited by 5 publications

(2 citation statements)

References 537 publications

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“…Progesterone increase growth and divisions of active uterine glands, and increase blood supply to the endometrium, all these changes will lead to increase of uterine weight. [24,25]. Ovarian and uterine weight increment in prepubertal animals considered as one of the criteria that can be used in the bioassay of these hormones [26,27].…”

Section: Discussionmentioning

confidence: 99%

Purification of some active ingredients of alcoholic extract of anise seed (Pimpinella anisum) and assessment their estrogenic effect on some physiological traits of immature female mice

obead¹,

Al-mzaein²,

Al-Jumaily³

2009

JoBRC

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This experiment was conducted in order to purify some active ingredients of 70% alcoholic extract of aniseed by adsorption chromatography on silica gel and gel filtration on sepharose CL-6B column, using phosphate buffer (0.1M, pH 7.0) as eluent, as well as gel filtration on sephadex LH-20 where chloroform : methanol (3:1) was used as an eluent. Thin layer chromatography on silica gel was used as a criterion for the identification of purified fractions. Ultra violet transilluminator as well as vanillin-H2SO4 reagent were used to identify and develop of separated fractions, respectively. However, the fractions which purified on sephadex LH-20, showed an Rf value (0.71) which corresponded to the Rf values of anethole. To assess the estrogenic activity of purified fractions a dose of 150 mg/kg of body weight of collected fractions were given to immature female mice at three weeks age and administered orally for four weeks period. Twenty immature female mice were divided randomly into five groups. First group received crude extract of aniseed, while the second, third, and fourth groups received fractions purified on silica gel, sepharose CL-6B and sephadex LH-20 columns, respectively. Group five served as control, such treatments were continued until maturity, and then the animals were sacrified for studying weight changes in ovaries and uterus. The results of this study revealed that there is a significant increment (P<0.01) in the weights of ovaries in the treated groups as compared to the control, while fractions obtained from sepharose CL-6B had no significant effect (P>0.01). Also there is a significant increment (P<0.01) in the weights of uterus in the treated group with respect to fractions obtained from sephadex LH- 20 as compared to other treated groups and control.

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Section: Discussionmentioning

confidence: 99%

Purification of some active ingredients of alcoholic extract of anise seed (Pimpinella anisum) and assessment their estrogenic effect on some physiological traits of immature female mice

obead¹,

Al-mzaein²,

Al-Jumaily³

2009

JoBRC

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“…With regard to their relative binding affinity (RBA) to Estrogen Receptor (ER), with the exclusion of estretrol, estrogens are ranked in the following order: estradiol > estrone > estriol. In comparison to estradiol, the activity and potency of estrone and estriol are, respectively, 10 and 100 times lower than that of E2 [ 4 ]. E1 mainly functions as estradiol’s metabolite and, at the same time, serves as its precursor (the estrone-to-estradiol transformation is reversible) [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Application of Various Molecular Modelling Methods in the Study of Estrogens and Xenoestrogens

Mazurek

Szeleszczuk

Simonson

et al. 2020

IJMS

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In this review, applications of various molecular modelling methods in the study of estrogens and xenoestrogens are summarized. Selected biomolecules that are the most commonly chosen as molecular modelling objects in this field are presented. In most of the reviewed works, ligand docking using solely force field methods was performed, employing various molecular targets involved in metabolism and action of estrogens. Other molecular modelling methods such as molecular dynamics and combined quantum mechanics with molecular mechanics have also been successfully used to predict the properties of estrogens and xenoestrogens. Among published works, a great number also focused on the application of different types of quantitative structure–activity relationship (QSAR) analyses to examine estrogen’s structures and activities. Although the interactions between estrogens and xenoestrogens with various proteins are the most commonly studied, other aspects such as penetration of estrogens through lipid bilayers or their ability to adsorb on different materials are also explored using theoretical calculations. Apart from molecular mechanics and statistical methods, quantum mechanics calculations are also employed in the studies of estrogens and xenoestrogens. Their applications include computation of spectroscopic properties, both vibrational and Nuclear Magnetic Resonance (NMR), and also in quantum molecular dynamics simulations and crystal structure prediction. The main aim of this review is to present the great potential and versatility of various molecular modelling methods in the studies on estrogens and xenoestrogens.

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U

Albinus

Amschler

et al. 1994

Hagers Handbuch Der Pharmazeutischen Praxis

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The Ovary

Cited by 5 publications

References 537 publications

Purification of some active ingredients of alcoholic extract of anise seed (Pimpinella anisum) and assessment their estrogenic effect on some physiological traits of immature female mice

Purification of some active ingredients of alcoholic extract of anise seed (Pimpinella anisum) and assessment their estrogenic effect on some physiological traits of immature female mice

Application of Various Molecular Modelling Methods in the Study of Estrogens and Xenoestrogens

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