The Ovarian Theca Cell. Iv. The Hyperthecosis Syndrome

Shippel, S.

doi:10.1097/00006254-195704000-00044

Cited by 3 publications

(4 citation statements)

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“…The theca luteinization has been regarded as a distinctive feature of polycystic ovaries [4,5,17,18], This interpretation, however, has been clearly rejected [6. 8].…”

Section: Discussionmentioning

confidence: 99%

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Ovarian Morphology in Patients with Polycystic Ovaries and in an Age-Matched Reference Material

Lunde¹,

Hoel²,

Sandvik³

1988

Gynecol Obstet Invest

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The ovarian morphology in 149 patients with the clinical syndrome of polycystic ovaries (group I) is described. The ovaries from 10 age-matched women (group II) with no signs of ovarian disorder were investigated as a reference material. The number of cysts documented for group I was twice that of the reference group and the ovarian volume three times that of the normals. No significant difference in follicle number was seen between the two groups. The tunica albuginea was thicker in group I with more pronounced atretic changes. The duration of symptoms for group I correlated significantly with body mass index, thickening of tunica, degree of stromal hyperplasia and the calculated means of ovarian volume. A correlation was also seen between ovarian volume, degree of follicular atresia and stromal hyperplasia, as well as between the thickness of the tunica albuginea, number of follicles and degree of follicular atresia.

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“…The theca luteinization has been regarded as a distinctive feature of polycystic ovaries [4,5,17,18], This interpretation, however, has been clearly rejected [6. 8].…”

Section: Discussionmentioning

confidence: 99%

“…There is evidence both for [17,20] and against [6] hyperthecosis in PCO. The differ ence might be a matter of definition.…”

Section: Discussionmentioning

confidence: 99%

Ovarian Morphology in Patients with Polycystic Ovaries and in an Age-Matched Reference Material

Lunde¹,

Hoel²,

Sandvik³

1988

Gynecol Obstet Invest

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“…4). The follicles were judged to be in the second stage of atresia with moderate to marked hyperthecosis (Shippel, 1955;Fienberg, 1963; Mori, Fig. 2.…”

Section: Follicular Morphologymentioning

confidence: 99%

STEROIDOGENESIS IN VITRO BY HUMAN OVARIAN FOLLICLES DURING THE PROCESS OF ATRESIA

Mori

Fujita

Nihnobu

et al. 1982

Clinical Endocrinology

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Slices of each of the six antral follicles at different stages of atresia isolated from ovaries of six patients with or without pretreatment with HCG before laparotomy, were incubated with [1-14C] acetate. Incorporation into progestins, androgens and oestrogens was assessed by the reverse dilution technique with recrystallization to constant specific activity. The greatest incorporation into androstenedione without any incorporation into progesterone was commonly observed throughout the morphologically defined three stages of atresia. In the first stage atretic follicles, characterized by coexistence of normally developed thecal cells with degenerating granulosa cells, a minute incorporation into oestradiol was identified. In the second state atretic follicles, showing hyperplasia and hypertrophy of thecal cells without granulosa cells, an increased incorporation into androgens was shown. Treatment with HCG induced similar but much pronounced changes in function and morphology. In the third stage atretic follicles, with subsiding thecal cells, a diminished incorporation into androstenedione was observed with 17-hydroxyprogesterone being the only other steroid formed in this stage. The observed qualitative and quantitative changes of steroidogenesis in vitro may be functional reflections of structural changes during the atretic process.

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“…On occasion proliferation of the theca interna cells of the ovary is found. This spectrum of pathological changes and the clinical sequelae has been called the hyperthecosis syndrome (Shippel, 1955). Treatment of the menstrual irregularity and anovulation in polycystic ovarian disease is beyond the scope of this review.…”

Section: R Londonmentioning

confidence: 99%

Hirsutism

London

1975

Postgraduate Medical Journal

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Summary Hirsutism is usually caused either by an increase in androgen production by the ovary or adrenal or it may be due to increased sensitivity of the hair follicle to normal amounts of circulating androgens. The diagnostic possibilities can be resolved on clinical grounds by laparoscopy and by hormone measurements. The commonest causes of this symptom are ‘idiopathic hirsutism’ and the polycystic ovary syndrome. Treatment is of the underlying condition or, when that is not possible, by local removal of hair or by the administration of oral contraceptives or glucocorticoids.

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The Ovarian Theca Cell. Iv. The Hyperthecosis Syndrome

Cited by 3 publications

References 0 publications

Ovarian Morphology in Patients with Polycystic Ovaries and in an Age-Matched Reference Material

Ovarian Morphology in Patients with Polycystic Ovaries and in an Age-Matched Reference Material

STEROIDOGENESIS IN VITRO BY HUMAN OVARIAN FOLLICLES DURING THE PROCESS OF ATRESIA

Hirsutism

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