The ovarian response to standard gonadotropin stimulation is influenced by<i>AMHRII</i>genotypes

Lazaros, Leandros; Fotaki, Anthi; Pamporaki, Christina; Hatzi, Elissavet; Kitsou, Chrysoula; Zikopoulos, Athanasios; Virgiliou, Christina; Kosmas, Ioannis; Bouba, Ioanna; Stefos, Theodoros; Theodoridis, Georgios; Georgiou, Ioannis

doi:10.3109/09513590.2016.1149810

Cited by 12 publications

(18 citation statements)

References 32 publications

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“…It is possible that the Ile49Ser and -482A>G polymorphisms are merely markers for the truly functional polymorphism elsewhere in these genes [15]. Lazaros et al [32] suggested a concerted effect between -482A>G and 1749C4T, since both polymorphisms in AMHRII were found to be in strong LD. Genome wide association studies may be promising as did a recent one that found significant correlation with ovarian response [55].…”

Section: Resultsmentioning

confidence: 99%

“…It is also likely that variants in other than AMH or AMHRII are relevant to RO and PCOS [15,31,32,40]. It is possible that the Ile49Ser and -482A>G polymorphisms are merely markers for the truly functional polymorphism elsewhere in these genes [15].…”

Section: Resultsmentioning

confidence: 99%

“…(iv) Pooled ORs of -482A>G in RO and PCOS were robust in the homozygous and recessive models. On the other hand, there are a number of limitations in our study: (i) [32,34,[38][39][40].…”

Section: Cellular Physiology and Biochemistrymentioning

confidence: 99%

“…Of the four comparisons, Ile49Ser in RO was least robust as the pooled ORs were altered with omission of a total of five studies [16,30,31,36,43] in every genetic model. By contrast, -482A>G was non-robust in the dominant model only, attributed to two studies [32,43]. In terms of genetic model, pooled ORs in the homozygous and recessive models were deemed robust in -482A>G comparisons.…”

Section: Heterogeneity Analysismentioning

confidence: 99%

“…Eight studies each were Asian [33,[35][36][37][40][41][42][43] and Caucasian [16, 19, 30-32, 34, 38, 39]. In terms of study context for Ile49Ser, five focused on infertility or ovarian insufficiency [16,33,36,37,43] and three addressed stimulation issues [30,32,35]. One was about assisted reproductive technology [31] and another addressed follicle recruitment [34].…”

Section: Meta-analysismentioning

confidence: 99%

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Associations of Polymorphisms in Anti-Müllerian Hormone (AMH Ile49Ser) and its Type II Receptor (AMHRII -482 A>G) on Reproductive Outcomes and Polycystic Ovary Syndrome: a Systematic Review and Meta-Analysis

Pabalan

Montagna

Singian

et al. 2016

Cell Physiol Biochem

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Background/Aims: Reported associations of reproductive outcomes (RO) and polycystic ovary syndrome (PCOS) with genotypes of the Ile49Ser and -482A>G polymorphisms in the Anti-Müllerian hormone (AMH) gene and its type II receptor (AMHRII), respectively, have conflicting results. Methods: PubMed, Google Scholar and Science Direct databases were searched for studies that investigated Ile49Ser and -482A>G in RO and PCOS. Using the metaanalytic approach, we estimated risk (odds ratio [OR] with 95% confidence intervals) using standard genetic models. Results: All calculated summary effects were non-significant. Overall associations of Ile49Ser and -482A>G with RO were absent (OR 0.95-0.99, P = 0.76-0.96) but implied increased risk in PCOS (OR 1.07-1.17, P = 0.49-0.55). Where heterogeneity of the pooled ORs were present, its sources were explored using the Galbraith plot. Detection and omission of the outlying studies in both polymorphisms not only erased heterogeneity of the recalculated pooled outcomes but also changed direction of association, where null effects turned to increased risk (Ile49Ser in RO) and increased risk became reduced risk (-482A>G in PCOS). Implications of the Ile49Ser and -482A>G, effects pointed to protection for Caucasians (OR 0.64-0.89, P = 0.36-0.73) in RO and increased risk in PCOS (OR 1.19-1.45, P = 0.28-0.65). Asian effects in RO and PCOS were variable (OR 0.97-1.24, P = 0.58-0.91). Conclusions: In summary, we found no evidence of significant associations of Ile49Ser and -482A>G with RO and PCOS, although contrasting Ile49Ser effects were implied among Caucasians between RO (up to 0.36% reduced risk) and PCOS (up to 1.5-fold increased risk).

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…(iv) Pooled ORs of -482A>G in RO and PCOS were robust in the homozygous and recessive models. On the other hand, there are a number of limitations in our study: (i) [32,34,[38][39][40].…”

Section: Cellular Physiology and Biochemistrymentioning

confidence: 99%

Section: Heterogeneity Analysismentioning

confidence: 99%

Section: Meta-analysismentioning

confidence: 99%

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Associations of Polymorphisms in Anti-Müllerian Hormone (AMH Ile49Ser) and its Type II Receptor (AMHRII -482 A>G) on Reproductive Outcomes and Polycystic Ovary Syndrome: a Systematic Review and Meta-Analysis

Pabalan

Montagna

Singian

et al. 2016

Cell Physiol Biochem

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The implication of single‐nucleotide polymorphisms in ovarian hyperstimulation syndrome

Ghaderian

Akbarzadeh

Mohajerani

et al. 2019

Molecular Reproduction Devel

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Ovarian hyperstimulation syndrome (OHSS) is an undesirable complication in the course of ovarian stimulation. This kind of stimulation is aimed at acquiring a sufficient number of high‐quality oocytes in in vitro fertilization (IVF). Whereas the predisposition to OHSS could be impacted by genetic polymorphisms in susceptible genes, the present study has been jointly conducted with an Iranian cohort to scrutinize its relevant implication. Genomic DNA was extracted from blood samples of patients with a normal ovarian response (NOR) or with OHSS. Samples were analyzed to detect polymorphisms MTHFR rs1801131, MTHFR rs1801133, AMHR2 rs2002555, LHCGR rs2293275, PGR rs10895068, and SERPINE1 rs1799889. Variations of MTHFR, AMHR2, LHCGR, and PGR genes were significantly associated with the developing OHSS. After correction for multiple analysis, this difference was not evident for PGR genotypes. The polymorphic alleles of MTHFR (rs1801131 C‐allele and rs1801133 T‐allele), AMHR2 (rs2002555 G‐allele), and LHCGR (rs2293275 G‐allele) were significantly more prevalent among patients with OHSS compared to those in the NOR group. In contrast, the minor allele of PGR single‐nucleotide polymorphism (SNP) (rs10895068, A‐allele) was more prominent among patients with a NOR than those with OHSS. No significant difference was observed in genotypes or alleles of SERPINE1 rs1799889. The observations indicated that the minor alleles of MTHFR, AMHR2, and LHCGR genes could be considered an independent risk factor in susceptibility to OHSS. Nevertheless, polymorphic allele in the PGR rs10895068 SNP contributes to preventing OHSS occurrence. Therefore, it can be argued that these genes have a significant impact on OHSS.

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Involvement of single nucleotide polymorphisms in ovarian poor response

Ghaderian

Akbarzadeh

Salehpour

2021

J Assist Reprod Genet

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Purpose Unpredictability in acquiring an adequate number of high-quality oocytes following ovarian stimulation is one of the major complications in controlled ovarian hyperstimulation (COH). Genetic predispositions of variations could alter the immunological profiles and consequently be implicated in the variability of ovarian response to the stimulation. Design Uncovering the influence of variations in AMHR2, LHCGR, MTHFR, PGR, and SERPINE1 genes with ovarian response to gonadotrophin stimulation in COH of infertile women. Methods Blood samples of the women with a good ovarian response (GOR) or with a poor ovarian response (POR) were collected. Genomic DNA was extracted, and gene variations were genotyped by TaqMan SNP Genotyping Assays using primer-probe sets or real-time PCR Kit. Results Except for PGR (rs10895068), allele distributions demonstrate that the majority of POR patients carried minor alleles of AMHR2 (rs2002555, G-allele), LHCGR (rs2293275, G-allele), MTHFR (rs1801131, C-allele, and rs1801133, T-allele), and SERPINE1 (rs1799889, 4G allele) genes compared to the GOR. Similarly, genotypes with a minor allele in AMHR2, LHCGR, MTHFR, and SERPINE1 genes had a higher prevalence among POR patients with the polymorphic genotypes. However, further genotype stratification indicated that the minor alleles of these genes are not associated with poor response. Multivariate logistic analysis of clinical−demographic factors and polymorphic genotypes demonstrated a correlation between FSH levels and polymorphic genotypes of SERPINE1 in poor response status. Conclusions Despite a higher prevalence of AMHR2, LHCGR, MTHFR, and SERPINE1 variations in the patients with poor ovarian response, it seems that these variations are not associated with the ovarian response.

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The ovarian response to standard gonadotropin stimulation is influenced byAMHRIIgenotypes

Cited by 12 publications

References 32 publications

Associations of Polymorphisms in Anti-Müllerian Hormone (AMH Ile49Ser) and its Type II Receptor (AMHRII -482 A>G) on Reproductive Outcomes and Polycystic Ovary Syndrome: a Systematic Review and Meta-Analysis

Associations of Polymorphisms in Anti-Müllerian Hormone (AMH Ile49Ser) and its Type II Receptor (AMHRII -482 A>G) on Reproductive Outcomes and Polycystic Ovary Syndrome: a Systematic Review and Meta-Analysis

The implication of single‐nucleotide polymorphisms in ovarian hyperstimulation syndrome

Involvement of single nucleotide polymorphisms in ovarian poor response

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