The outcomes of total hip arthroplasty in rapidly progressive osteoarthritis: a systematic review

Baryeh, Kwaku; Asopa, Vipin; Field, Richard E.; Sochart, David H.

doi:10.1007/s00590-022-03396-8

Cited by 9 publications

(12 citation statements)

References 44 publications

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“…It was reported that SDS remains in decellularized tissues may act as a cytotoxic agent. 37,38 Consecutive washing in phosphate-buffered saline (PBS) and distilled water results in a significant reduction in SDS concentration. Moreover, applying Triton X-100 also successfully lowers the SDS concentration in the materials, thus improving the cytocompatibility of the decellularized tissues.…”

Section: Discussionmentioning

confidence: 99%

Decellularization of the human urethra for tissue engineering applications

Kuniaková

Klein

Gálfiová

et al. 2023

Exp Biol Med (Maywood)

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Recently, several scaffolds have been introduced for urethral tissue engineering. However, acellular human urethral scaffold harvested from deceased donors may provide significant advantages compared to synthetic, composite, or other biological scaffolds. This study aims to develop the protocol for decellularization of the human urethra that preserves substantial extracellular matrix (ECM) components, which are essential for subsequent recellularization mimicking the natural environment of the native ECM. A total of 12 human urethras were harvested from deceased donors. An equal part of every harvested urethra was used as a control sample for analyses. The protocol design was based on the enzyme-detergent-enzyme method. Trypsin and Triton X-100 were used to remove cells, followed by DNase treatment to remove DNA residues. Subsequently, the specimens were continually rinsed in deionized water for seven days. The efficiency of decellularization was determined by histochemistry, immunohistochemical staining, scanning electron microscopy (SEM), and DNA quantification. Histological analysis confirmed cell removal and preservation of urethral structure after decellularization. The preservation of collagen IV and fibronectin was confirmed by histologic examination and immunohistochemical staining. SEM confirmed the maintenance of the ultrastructural architecture of ECM and fibers. DNA content in decellularized urethra was significantly lower compared to the native sample ( P < 0.001), and so the criteria for decellularized tissue were met. Cytotoxicity analysis data showed that the matrix-conditioned medium did not contain soluble toxins and had no significant inhibitory effect on cell proliferation, providing evidence that the decellularized samples are not toxic. This study demonstrates the feasibility of the enzyme-detergent-enzyme–based decellularization protocol for removing cellular components and maintaining urethral ECM and its ultrastructure. Moreover, obtained results provide solid ground for recellularization and urethral tissue engineering, which will follow.

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Section: Discussionmentioning

confidence: 99%

Decellularization of the human urethra for tissue engineering applications

Kuniaková

Klein

Gálfiová

et al. 2023

Exp Biol Med (Maywood)

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“…In some cases, the almost complete disappearance of the femoral head within a few months can be observed ( Figure 1 ) [ 4 ]. Generally, either the right or the left hip joint is affected, and it is mostly seen in elderly females aged between 70 and 75 years [ 5 ]. However, there are also reports of bilateral appearance.…”

Section: Introductionmentioning

confidence: 99%

“…However, there are also reports of bilateral appearance. Clinically, patients present with acute severe and rapidly worsening hip pain [ 4 , 5 ]. Today, multiple descriptive terms for this condition, such as rapidly destructive osteoarthritis (RDO), rapidly progressive coxarthrosis, Postel’s osteoarthritis, and rapidly progressive hip disease, have been proposed [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D Deficiency Is Frequent in Patients with Rapidly Destructive Osteoarthritis—Data from a Single-Center Analysis

Horas,

Maier,

Rudert

et al. 2024

JCM

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Background: Rapidly destructive osteoarthritis (RDO) of the hip joint is characterised by the rapid destruction of the femoral head with or without acetabular involvement. There has been increasing interest in this disease over the past years; however, the entity is still poorly understood, and its pathophysiology remains unknown. Yet, there is ample evidence today that increased bone metabolism might play a role in the onset and progression of the disease. Vitamin D is of utmost importance to maintain a balanced bone metabolism. However, whether vitamin D deficiency is involved in disease development remains to be elucidated. Further, the vitamin D status of patients with RDO has not yet been analysed. For this reason, the objective of this study was to assess the vitamin D status of patients with RDO. Moreover, the aim was to clarify whether there is a difference in the vitamin D status of patients with RDO compared with patients with primary osteoarthritis (OA). Methods: In this single-centre analysis, the 25(OH)D, PTH, and calcium levels of 29 patients who presented with RDO between 2020 and 2022 were assessed. Results: Altogether, 97% of patients (28/29) were vitamin D deficient, a further 3% (1/29) were vitamin D insufficient, and not a single patient presented with a sufficient vitamin D status. Notably, the vitamin D levels of RDO patients (mean = 11.04 ng/mL) were significantly lower than the vitamin D levels of patients with OA (mean = 22.16 ng/mL, p = 0.001). Conclusion: In conclusion, we found a widespread and high rate of vitamin D deficiency in patients with RDO. Hence, we believe that 25(OH)D status should routinely be analysed in these patients.

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“…Total hip arthroplasty (THA) is becoming a more standardized procedure with high satisfactory rate in patients with hip osteoarthritis, osteonecrosis of the femoral head, and rapidly destructive coxarthrosis (RDC) 8–10 . However, patients with Parkinson's disease have a high dislocation rate of 8%–37% after THA 11,12 .…”

Section: Introductionmentioning

confidence: 99%

“…7 Total hip arthroplasty (THA) is becoming a more standardized procedure with high satisfactory rate in patients with hip osteoarthritis, osteonecrosis of the femoral head, and rapidly destructive coxarthrosis (RDC). [8][9][10] However, patients with Parkinson's disease have a high dislocation rate of 8%-37% after THA. 11,12 Although the patients suffer from severe hip pain, they do not prefer undergoing surgery; however, their walking capacity can be comprised if they do not receive appropriate surgical treatment.…”

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confidence: 99%

Levodopa‐Carbidopa Intestinal Gel Injection for Patient with Severe Parkinson's Disease Followed by Total Hip Arthroplasty: A Case Report and Literature Review

Imamura,

Kuroyanagi,

Usami

et al. 2023

Orthopaedic Surgery

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BackgroundPatients with Parkinson's disease have a high dislocation rate after total hip arthroplasty (THA). This study describes a case with severe Parkinson's disease who developed rapidly destructive coxarthrosis (RDC) and underwent THA using a dual mobility cup after a levodopa‐carbidopa intestinal gel (LCIG) infusion.Case presentationThe patient is a 59‐year‐old female with a ten‐year history of Parkinson's disease, which was first treated with oral levodopa. The patient developed RDC of the right hip joint. However, THA was difficult owing to Parkinson's disease and its treatment side effects, such as wearing‐off, dyskinesia, and freezing of the gait, Thus, LCIG was initiated, and improvement in wearing‐off and dyskinesia was observed. Two months after the LCIG therapy, the disease was controlled well. THA was subsequently performed using a dual mobility cup to prevent postoperative dislocation. Postoperatively, LCIG therapy was continuously administered to carefully manage the disease, which was controlled well with no increase in wearing‐off and dyskinesia after surgery. At 1 year after surgery, the walking speed, stride length, and the Harris hip score improved compared to preoperatively. The UPDRS III motor score improved to eight without signs of wearing‐off or dyskinesia. The Hoehn‐Yahr scale was II in the “on” period and remained unchanged 1 year after surgery. The patient could walk without a cane and had satisfactory functional outcomes.ConclusionThis case proved that LCIG treatment performed preoperatively, followed by THA using a dual mobility cup, and strict management of Parkinson's disease could result in a satisfactory clinical course without recurrence of wearing‐off and dyskinesia. Similar procedures may benefit other patients with Parkinson's disease who have previously been deemed unsuitable for THA.

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The outcomes of total hip arthroplasty in rapidly progressive osteoarthritis: a systematic review

Cited by 9 publications

References 44 publications

Decellularization of the human urethra for tissue engineering applications

Decellularization of the human urethra for tissue engineering applications

Vitamin D Deficiency Is Frequent in Patients with Rapidly Destructive Osteoarthritis—Data from a Single-Center Analysis

Levodopa‐Carbidopa Intestinal Gel Injection for Patient with Severe Parkinson's Disease Followed by Total Hip Arthroplasty: A Case Report and Literature Review

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